| 词条 | Keratoglobus |
| 释义 |
| name = Keratoglobus | synonyms = | image = | caption = | pronounce = | field = | symptoms = | complications = | onset = | duration = | types = | causes = | risks = | diagnosis = | differential = | prevention = | treatment = | medication = | prognosis = | frequency = | deaths = }} Keratoglobus (from Greek: kerato- horn, cornea; and Latin: globus round), is a degenerative non-inflammatory disorder of the eye in which structural changes within the cornea cause it to become extremely thin and change to a more globular shape than its normal gradual curve. It causes corneal thinning, primarily at the margins, resulting in a spherical, slightly enlarged eye. It is sometimes equated with "megalocornea".[1] PathophysiologyKeratoglobus is a little-understood disease with an uncertain cause, and its progression following diagnosis is unpredictable. If afflicting both eyes, the deterioration in vision can affect the patient's ability to drive a car or read normal print. It does not however lead to blindness per se. TreatmentTreatment includes the use of protective eye glasses.[2] A number of surgical options are also available.[2] Further progression of the disease usually leads to a need for corneal transplantation because of extreme thinning of the cornea. Primarily, large size penetrating keratoplasty has been advocated. Recent additions of techniques specifically for keratoglobus include the "tuck procedure",[3] whereby a 12 mm corneo-scleral donor graft is taken and trimmed at its outer edges. A host pocket is formed at the limbal margin and the donor tissue is "tucked" into the host pocket. PrognosisKeratoglobus continues to be a somewhat mysterious disease, but it can be successfully managed with a variety of clinical and surgical techniques. The patient is at risk for globe perforation because the thinned out cornea is extremely weak. EpidemiologyIt is a much rarer condition than keratoconus, which is the most common dystrophy of the cornea.[4] Similar to keratoconus it is typically diagnosed in the patient's adolescent years and attains its most severe state in the twenties and thirties. References1. ^{{DorlandsDict|five/000056141|keratoglobus}} 2. ^1 {{cite journal|last1=Wallang|first1=BS|last2=Das|first2=S|title=Keratoglobus.|journal=Eye (London, England)|date=September 2013|volume=27|issue=9|pages=1004–12|pmid=23807384|doi=10.1038/eye.2013.130|pmc=3772364}} 3. ^{{cite journal |vauthors=Kaushal S, Jhanji V, Sharma N, Tandon R, Titiyal JS, Vajpayee RB |title="Tuck In" Lamellar Keratoplasty (TILK) for corneal ectasias involving corneal periphery |journal=Br J Ophthalmol |volume=92 |issue=2 |pages=286–90 |date=February 2008 |pmid=18227208 |doi=10.1136/bjo.2007.124628 |url=http://bjo.bmj.com/cgi/pmidlookup?view=long&pmid=18227208}} 4. ^{{cite web |url=http://www.revoptom.com/index.asp?page=2_1595.htm |title=Archived copy |accessdate=2006-10-17 |deadurl=yes |archiveurl=https://web.archive.org/web/20070310232819/http://www.revoptom.com/index.asp?page=2_1595.htm |archivedate=2007-03-10 |df= }} External links{{Medical resources| DiseasesDB = 32591 | ICD10 = {{ICD10|Q|15|0|q|10}} | ICD9 = {{ICD9|743.22}} | ICDO = | OMIM = | MedlinePlus = | eMedicineSubj = | eMedicineTopic = | MeshID = }}{{Eye pathology}}{{Congenital malformations and deformations of eye, ear, face and neck}} 1 : Congenital disorders of eyes |
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