释义 |
- References
- Further reading
- External links
{{Infobox_gene}}Kallikrein-2 is a protein that in humans is encoded by the KLK2 gene, and is particularly associated with prostatic tissue.[1][2][3][4]References1. ^{{cite journal |vauthors=Riegman PH, Vlietstra RJ, Klaassen P, van der Korput JA, Geurts van Kessel A, Romijn JC, Trapman J | title = The prostate-specific antigen gene and the human glandular kallikrein-1 gene are tandemly located on chromosome 19 | journal = FEBS Lett | volume = 247 | issue = 1 | pages = 123–126 |date=May 1989 | pmid = 2468530 | pmc = | doi =10.1016/0014-5793(89)81253-0 }} 2. ^{{cite journal |vauthors=Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM | title = A comprehensive nomenclature for serine proteases with homology to tissue kallikreins | journal = Biol Chem | volume = 387 | issue = 6 | pages = 637–641 |date=Jun 2006 | pmid = 16800724 | pmc = | doi = 10.1515/BC.2006.082 }} 3. ^{{cite journal | author = | title = Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005 | journal = Biol Chem | volume = 387 | issue = 6 | pages = 635–636 |date=Jun 2006 | pmid = 16800723 | pmc = | doi = 10.1515/BC.2006.081 | last1 = Diamandis | first1 = Eleftherios P. | last2 = Deperthes | first2 = David | last3 = Lundwall | first3 = Åke }} 4. ^{{cite web | title = Entrez Gene: KLK2 Kallikrein-related peptidase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3817| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | author=Riegman PH |title=Identification and androgen-regulated expression of two major human glandular kallikrein-1 (hGK-1) mRNA species |journal=Mol. Cell. Endocrinol. |volume=76 |issue= 1–3 |pages= 181–190 |year= 1992 |pmid= 1726490 |doi=10.1016/0303-7207(91)90272-T |name-list-format=vanc| author2=Vlietstra RJ | author3=van der Korput HA | display-authors=3 | last4=Romijn | first4=JC | last5=Trapman | first5=J }}
- {{cite journal | author=Qin H |title=Localization of human glandular kallikrein-1 gene to chromosome 19q13.3-13.4 by in situ hybridization |journal=Hum. Hered. |volume=41 |issue= 4 |pages= 222–226 |year= 1992 |pmid= 1783409 |doi=10.1159/000154005 |name-list-format=vanc| author2=Kemp J | author3=Yip MY | display-authors=3 | last4=Lam-Po-Tang | first4=P.R.L | last5=Morris | first5=Brian J. }}
- {{cite journal |vauthors=Schedlich LJ, Bennetts BH, Morris BJ |title=Primary structure of a human glandular kallikrein gene |journal=DNA |volume=6 |issue= 5 |pages= 429–437 |year= 1988 |pmid= 2824146 |doi=10.1089/dna.1987.6.429 }}
- {{cite journal | author=Frenette G |title=Purification of enzymatically active kallikrein hK2 from human seminal plasma |journal=Biochim. Biophys. Acta |volume=1334 |issue= 1 |pages= 109–15 |year= 1997 |pmid= 9042371 |doi= 10.1016/s0304-4165(96)00080-3|name-list-format=vanc| author2=Deperthes D | author3=Tremblay RR | display-authors=3 | last4=Lazure | first4=C | last5=Dubé | first5=JY }}
- {{cite journal | author=Bourgeois L |title=Serpin-derived peptide substrates for investigating the substrate specificity of human tissue kallikreins hK1 and hK2 |journal=J. Biol. Chem. |volume=272 |issue= 47 |pages= 29590–29595 |year= 1997 |pmid= 9368023 |doi=10.1074/jbc.272.47.29590 |name-list-format=vanc| author2=Brillard-Bourdet M | author3=Deperthes D | display-authors=3 | last4=Juliano | first4=MA | last5=Juliano | first5=L | last6=Tremblay | first6=RR | last7=Dubé | first7=JY | last8=Gauthier | first8=F }}
- {{cite journal |vauthors=Mikolajczyk SD, Millar LS, Kumar A, Saedi MS |title=Human glandular kallikrein, hK2, shows arginine-restricted specificity and forms complexes with plasma protease inhibitors |journal=Prostate |volume=34 |issue= 1 |pages= 44–50 |year= 1998 |pmid= 9428387 |doi=10.1002/(SICI)1097-0045(19980101)34:1<44::AID-PROS6>3.0.CO;2-K }}
- {{cite journal |vauthors=Yu DC, Sakamoto GT, Henderson DR |title=Identification of the transcriptional regulatory sequences of human kallikrein 2 and their use in the construction of calydon virus 764, an attenuated replication competent adenovirus for prostate cancer therapy |journal=Cancer Res. |volume=59 |issue= 7 |pages= 1498–504 |year= 1999 |pmid= 10197620 |doi= }}
- {{cite journal |vauthors=Mikolajczyk SD, Millar LS, Kumar A, Saedi MS |title=Prostatic human kallikrein 2 inactivates and complexes with plasminogen activator inhibitor-1 |journal=Int. J. Cancer |volume=81 |issue= 3 |pages= 438–442 |year= 1999 |pmid= 10209959 |doi=10.1002/(SICI)1097-0215(19990505)81:3<438::AID-IJC18>3.0.CO;2-U }}
- {{cite journal | author=Lövgren J |title=Measurement of prostate-specific antigen and human glandular kallikrein 2 in different body fluids |journal=J. Androl. |volume=20 |issue= 3 |pages= 348–55 |year= 1999 |pmid= 10386814 |doi= |name-list-format=vanc| author2=Valtonen-André C | author3=Marsal K | display-authors=3 | last4=Lilja | first4=H | last5=Lundwall | first5=A }}
- {{cite journal | author=Cargill M |title=Characterization of single-nucleotide polymorphisms in coding regions of human genes |journal=Nat. Genet. |volume=22 |issue= 3 |pages= 231–238 |year= 1999 |pmid= 10391209 |doi= 10.1038/10290 |name-list-format=vanc| author2=Altshuler D | author3=Ireland J | display-authors=3 | last4=Ireland | first4=James | last5=Sklar | first5=Pamela | last6=Ardlie | first6=Kristin | last7=Patil | first7=Nila | last8=Lane | first8=Charles R. | last9=Lim | first9=Esther P. }}
- {{cite journal |vauthors=Lövgren J, Airas K, Lilja H |title=Enzymatic action of human glandular kallikrein 2 (hK2). Substrate specificity and regulation by Zn2+ and extracellular protease inhibitors |journal=Eur. J. Biochem. |volume=262 |issue= 3 |pages= 781–789 |year= 1999 |pmid= 10411640 |doi=10.1046/j.1432-1327.1999.00433.x }}
- {{cite journal | author=Mikolajczyk SD |title=Identification of a novel complex between human kallikrein 2 and protease inhibitor-6 in prostate cancer tissue |journal=Cancer Res. |volume=59 |issue= 16 |pages= 3927–30 |year= 1999 |pmid= 10463585 |doi= |name-list-format=vanc| author2=Millar LS | author3=Marker KM | display-authors=3 | last4=Rittenhouse | first4=HG | last5=Wolfert | first5=RL | last6=Marks | first6=LS | last7=Charlesworth | first7=MC | last8=Tindall | first8=DJ }}
- {{cite journal | author=Liu XF |title=Identification of three new alternate human kallikrein 2 transcripts: evidence of long transcript and alternative splicing |journal=Biochem. Biophys. Res. Commun. |volume=264 |issue= 3 |pages= 833–839 |year= 1999 |pmid= 10544017 |doi= 10.1006/bbrc.1999.1595 |name-list-format=vanc| author2=Essand M | author3=Vasmatzis G | display-authors=3 | last4=Lee | first4=B | last5=Pastan | first5=I }}
- {{cite journal | author=Ren F |title=Tea polyphenols down-regulate the expression of the androgen receptor in LNCaP prostate cancer cells |journal=Oncogene |volume=19 |issue= 15 |pages= 1924–1932 |year= 2000 |pmid= 10773882 |doi= 10.1038/sj.onc.1203511 |name-list-format=vanc| author2=Zhang S | author3=Mitchell SH | display-authors=3 | last4=Butler | first4=Rachel | last5=Young | first5=Charles YF }}
- {{cite journal | author=Harvey TJ |title=Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4 |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37397–37406 |year= 2001 |pmid= 10969073 |doi= 10.1074/jbc.M004525200 |name-list-format=vanc| author2=Hooper JD | author3=Myers SA | display-authors=3 | last4=Stephenson | first4=SA | last5=Ashworth | first5=LK | last6=Clements | first6=JA }}
- {{cite journal |vauthors=Chen VC, Chao L, Chao J |title=A positively charged loop on the surface of kallistatin functions to enhance tissue kallikrein inhibition by acting as a secondary binding site for kallikrein |journal=J. Biol. Chem. |volume=275 |issue= 51 |pages= 40371–40377 |year= 2001 |pmid= 10991942 |doi= 10.1074/jbc.M005691200 }}
- {{cite journal | author=Gan L |title=Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region |journal=Gene |volume=257 |issue= 1 |pages= 119–130 |year= 2001 |pmid= 11054574 |doi=10.1016/S0378-1119(00)00382-6 |name-list-format=vanc| author2=Lee I | author3=Smith R | display-authors=3 | last4=Argonza-Barrett | first4=R | last5=Lei | first5=H | last6=McCuaig | first6=J | last7=Moss | first7=P | last8=Paeper | first8=B | last9=Wang | first9=K }}
- {{cite journal | author=Réhault S |title=Insulin-like growth factor binding proteins (IGFBPs) as potential physiological substrates for human kallikreins hK2 and hK3 |journal=Eur. J. Biochem. |volume=268 |issue= 10 |pages= 2960–2968 |year= 2001 |pmid= 11358513 |doi=10.1046/j.1432-1327.2001.02185.x |name-list-format=vanc| author2=Monget P | author3=Mazerbourg S | display-authors=3 | last4=Tremblay | first4=Roland | last5=Gutman | first5=Ninette | last6=Gauthier | first6=Francis | last7=Moreau | first7=Thierry }}
- {{cite journal | author=Saedi MS |title=Human kallikrein 2 (hK2), but not prostate-specific antigen (PSA), rapidly complexes with protease inhibitor 6 (PI-6) released from prostate carcinoma cells |journal=Int. J. Cancer |volume=94 |issue= 4 |pages= 558–563 |year= 2002 |pmid= 11745444 |doi=10.1002/ijc.1501 |name-list-format=vanc| author2=Zhu Z | author3=Marker K | display-authors=3 | last4=Liu | first4=Ru‐Shya | last5=Carpenter | first5=Philip M. | last6=Rittenhouse | first6=Harry | last7=Mikolajczyk | first7=Stephen D. }}
{{refend}}External links- The MEROPS online database for peptidases and their inhibitors: S01.161
{{gene-19-stub}} |