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词条 KLKB1
释义

  1. Function

  2. Interactions

  3. See also

  4. References

  5. Further reading

{{Infobox_gene}}Plasma kallikrein is a protein that in humans is encoded by the KLKB1 gene.[1][2]

Function

Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulfide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.[3]

Interactions

KLKB1 has been shown to interact with High-molecular-weight kininogen.[4][5][6][7]

See also

  • Kallikrein, a group of enzymes that cleave peptide bonds in proteins

References

1. ^{{cite journal | vauthors = Yu H, Bowden DW, Spray BJ, Rich SS, Freedman BI | title = Identification of human plasma kallikrein gene polymorphisms and evaluation of their role in end-stage renal disease | journal = Hypertension | volume = 31 | issue = 4 | pages = 906–11 | date = April 1998 | pmid = 9535413 | pmc = | doi = 10.1161/01.hyp.31.4.906 }}
2. ^{{cite journal | vauthors = Chung DW, Fujikawa K, McMullen BA, Davie EW | title = Human plasma prekallikrein, a zymogen to a serine protease that contains four tandem repeats | journal = Biochemistry | volume = 25 | issue = 9 | pages = 2410–7 | date = August 1986 | pmid = 3521732 | pmc = | doi = 10.1021/bi00357a017 }}
3. ^{{cite web | title = Entrez Gene: KLKB1 kallikrein B, plasma (Fletcher factor) 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3818| accessdate = }}
4. ^{{cite journal | vauthors = Thompson RE, Mandle R, Kaplan AP | title = Studies of binding of prekallikrein and Factor XI to high molecular weight kininogen and its light chain | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 76 | issue = 10 | pages = 4862–6 | date = October 1979 | pmid = 291905 | pmc = 413037 | doi = 10.1073/pnas.76.10.4862 }}
5. ^{{cite journal | vauthors = Page JD, You JL, Harris RB, Colman RW | title = Localization of the binding site on plasma kallikrein for high-molecular-weight kininogen to both apple 1 and apple 4 domains of the heavy chain | journal = Arch. Biochem. Biophys. | volume = 314 | issue = 1 | pages = 159–64 | date = October 1994 | pmid = 7944388 | doi = 10.1006/abbi.1994.1424 }}
6. ^{{cite journal | vauthors = Herwald H, Jahnen-Dechent W, Alla SA, Hock J, Bouma BN, Müller-Esterl W | title = Mapping of the high molecular weight kininogen binding site of prekallikrein. Evidence for a discontinuous epitope formed by distinct segments of the prekallikrein heavy chain | journal = J. Biol. Chem. | volume = 268 | issue = 19 | pages = 14527–35 | date = July 1993 | pmid = 7686159 | doi = }}
7. ^{{cite journal | vauthors = Renné T, Dedio J, Meijers JC, Chung D, Müller-Esterl W | title = Mapping of the discontinuous H-kininogen binding site of plasma prekallikrein. Evidence for a critical role of apple domain-2 | journal = J. Biol. Chem. | volume = 274 | issue = 36 | pages = 25777–84 | date = September 1999 | pmid = 10464316 | doi = 10.1074/jbc.274.36.25777 }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Thompson RE, Mandle R, Kaplan AP | title = Studies of binding of prekallikrein and Factor XI to high molecular weight kininogen and its light chain | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 76 | issue = 10 | pages = 4862–6 | year = 1980 | pmid = 291905 | pmc = 413037 | doi = 10.1073/pnas.76.10.4862 }}
  • {{cite journal | vauthors = Aznar JA, España F, Aznar J, Tascon A, Jimenez C | title = Fletcher factor deficiency: report of a new family | journal = Scandinavian Journal of Haematology | volume = 21 | issue = 2 | pages = 94–8 | year = 1978 | pmid = 694428 | doi = 10.1111/j.1600-0609.1978.tb02498.x }}
  • {{cite book | vauthors = Henderson LM, Figueroa CD, Muller-Esterl W, Stain A, Bhoola KD | title = Immunovisualisation of plasma prekallikrein and H-kininogen on human neutrophils and in human hepatocytes | journal = Agents Actions Suppl. | volume = 38 | issue = 1 | pages = 590–4 | year = 1993 | pmid = 1466300 | doi = 10.1007/978-3-0348-7321-5_72 | isbn = 978-3-0348-7323-9 }}
  • {{cite journal | vauthors = Beaubien G, Rosinski-Chupin I, Mattei MG, Mbikay M, Chrétien M, Seidah NG | title = Gene structure and chromosomal localization of plasma kallikrein | journal = Biochemistry | volume = 30 | issue = 6 | pages = 1628–35 | year = 1991 | pmid = 1993180 | doi = 10.1021/bi00220a027 }}
  • {{cite journal | vauthors = McMullen BA, Fujikawa K, Davie EW | title = Location of the disulfide bonds in human plasma prekallikrein: the presence of four novel apple domains in the amino-terminal portion of the molecule | journal = Biochemistry | volume = 30 | issue = 8 | pages = 2050–6 | year = 1991 | pmid = 1998666 | doi = 10.1021/bi00222a007 }}
  • {{cite journal | vauthors = España F, Berrettini M, Griffin JH | title = Purification and characterization of plasma protein C inhibitor | journal = Thromb. Res. | volume = 55 | issue = 3 | pages = 369–84 | year = 1989 | pmid = 2551064 | doi = 10.1016/0049-3848(89)90069-8 }}
  • {{cite journal | vauthors = Fujikawa K, Chung DW, Hendrickson LE, Davie EW | title = Amino acid sequence of human factor XI, a blood coagulation factor with four tandem repeats that are highly homologous with plasma prekallikrein | journal = Biochemistry | volume = 25 | issue = 9 | pages = 2417–24 | year = 1986 | pmid = 3636155 | doi = 10.1021/bi00357a018 }}
  • {{cite journal | vauthors = Herwald H, Jahnen-Dechent W, Alla SA, Hock J, Bouma BN, Müller-Esterl W | title = Mapping of the high molecular weight kininogen binding site of prekallikrein. Evidence for a discontinuous epitope formed by distinct segments of the prekallikrein heavy chain | journal = J. Biol. Chem. | volume = 268 | issue = 19 | pages = 14527–35 | year = 1993 | pmid = 7686159 | doi = }}
  • {{cite journal | vauthors = Page JD, You JL, Harris RB, Colman RW | title = Localization of the binding site on plasma kallikrein for high-molecular-weight kininogen to both apple 1 and apple 4 domains of the heavy chain | journal = Arch. Biochem. Biophys. | volume = 314 | issue = 1 | pages = 159–64 | year = 1994 | pmid = 7944388 | doi = 10.1006/abbi.1994.1424 }}
  • {{cite journal | vauthors = Henderson LM, Figueroa CD, Müller-Esterl W, Bhoola KD | title = Assembly of contact-phase factors on the surface of the human neutrophil membrane | journal = Blood | volume = 84 | issue = 2 | pages = 474–82 | year = 1994 | pmid = 8025275 | doi = }}
  • {{cite journal | vauthors = Shimomura T, Kondo J, Ochiai M, Naka D, Miyazawa K, Morimoto Y, Kitamura N | title = Activation of the zymogen of hepatocyte growth factor activator by thrombin | journal = J. Biol. Chem. | volume = 268 | issue = 30 | pages = 22927–32 | year = 1993 | pmid = 8226803 | doi = }}
  • {{cite journal | vauthors = Ciechanowicz A, Bader M, Wagner J, Ganten D | title = Extra-hepatic transcription of plasma prekallikrein gene in human and rat tissues | journal = Biochem. Biophys. Res. Commun. | volume = 197 | issue = 3 | pages = 1370–6 | year = 1994 | pmid = 8280154 | doi = 10.1006/bbrc.1993.2628 }}
  • {{cite journal | vauthors = Petersen LC, Sprecher CA, Foster DC, Blumberg H, Hamamoto T, Kisiel W | title = Inhibitory properties of a novel human Kunitz-type protease inhibitor homologous to tissue factor pathway inhibitor | journal = Biochemistry | volume = 35 | issue = 1 | pages = 266–72 | year = 1996 | pmid = 8555184 | doi = 10.1021/bi951501d }}
  • {{cite journal | vauthors = Hermann A, Buchinger P, Somlev B, Rehbock J | title = High and low molecular weight kininogen and plasma prekallikrein/plasma kallikrein in villous capillaries of human term placenta | journal = Placenta | volume = 17 | issue = 4 | pages = 223–30 | year = 1996 | pmid = 8761966 | doi = 10.1016/S0143-4004(96)90042-9 }}
  • {{cite journal | vauthors = Durham SK, Suwanichkul A, Hayes JD, Herington AC, Powell DR, Campbell PG | title = The heparin binding domain of insulin-like growth factor binding protein (IGFBP)-3 increases susceptibility of IGFBP-3 to proteolysis | journal = Horm. Metab. Res. | volume = 31 | issue = 2–3 | pages = 216–25 | year = 1999 | pmid = 10226805 | doi = 10.1055/s-2007-978722 }}
  • {{cite journal | vauthors = Renné T, Dedio J, Meijers JC, Chung D, Müller-Esterl W | title = Mapping of the discontinuous H-kininogen binding site of plasma prekallikrein. Evidence for a critical role of apple domain-2 | journal = J. Biol. Chem. | volume = 274 | issue = 36 | pages = 25777–84 | year = 1999 | pmid = 10464316 | doi = 10.1074/jbc.274.36.25777 }}
  • {{cite journal | vauthors = Hermann A, Arnhold M, Kresse H, Neth P, Fink E | title = Expression of plasma prekallikrein mRNA in human nonhepatic tissues and cell lineages suggests special local functions of the enzyme | journal = Biol. Chem. | volume = 380 | issue = 9 | pages = 1097–102 | year = 1999 | pmid = 10543447 | doi = 10.1515/BC.1999.136 | citeseerx = 10.1.1.657.2854 }}
  • {{cite journal | vauthors = Cerf M, Raidoo D, Fink E, Fritz H, Bhoola K | title = Plasma kallikrein localisation in human blood vessels | journal = Immunopharmacology | volume = 44 | issue = 1–2 | pages = 75–80 | year = 2000 | pmid = 10604527 | doi = 10.1016/S0162-3109(99)00112-5 }}
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