| 词条 | KLRA1 |
| 释义 |
| Name = killer cell lectin-like receptor, subfamily A, member 2 | image = | width = | caption = | Organism = Mus musculus | TaxID = 10090 | Symbol = Klra2 | AltSymbols = Ly49b; Klra30 | EntrezGene = 16633 | PDB = | RefSeqmRNA = NM_008462.5 | RefSeqProtein = NP_032488.4 | UniProt = Q60660 | ECnumber = | Chromosome = 6 | EntrezChromosome = NC_000072.6 | GenLoc_start = 131215015 | GenLoc_end = 131251580 }}{{infobox protein |Name= Killer cell lectin-like receptor subfamily A pseudogene 1 |caption= |image= |width= |HGNCid=6372 |Symbol= KLRAP1 |AltSymbols= KLRA1; Ly49; LY49L; Ly-49L |EntrezGene=10748 |OMIM=604274 |RefSeq=NM_006611 |UniProt=O75889 |PDB= |ECnumber= |Chromosome=12 |Arm=p |Band=12 |LocusSupplementaryData=-p13 }} Ly-49 receptors or killer cell lectin-like receptor subfamily A (KLRA), are a class of natural killer cell receptor.[1][2] Ly-49 proteins are a diverse set of C-type lectins that are expressed on NK cells in some mammals, including rodents but not humans. Their primary function is to bind host MHC class I as a mechanism of self/health recognition. Upon binding ligands, most Ly-49 receptors will deliver an inhibitory signal, preventing killing of the target cell. In the case of cancer or virally infected cells, MHC-I will often be downregulated in order to limit cytotoxic T cell mediated killing of the cell, whereby NK cells will lack Ly-49 inhibitory signal and be able to kill infected or cancerous target cells. The homologous human KLRAP1 gene has been classified as a transcribed pseudogene because all associated transcripts are candidates for nonsense-mediated decay (NMD).[3][4] References1. ^{{cite journal |vauthors=Nylenna O, Naper C, Vaage JT, Woon PY, Gauguier D, Dissen E, Ryan JC, Fossum S | title = The genes and gene organization of the Ly49 region of the rat natural killer cell gene complex | journal = Eur. J. Immunol. | volume = 35 | issue = 1 | pages = 261–72 |date=January 2005 | pmid = 15593300 | doi = 10.1002/eji.200425429 }} 2. ^{{cite journal |vauthors=Gays F, Aust JG, Reid DM, Falconer J, Toyama-Sorimachi N, Taylor PR, Brooks CG | title = Ly49B is expressed on multiple subpopulations of myeloid cells | journal = J. Immunol. | volume = 177 | issue = 9 | pages = 5840–51 |date=November 2006 | pmid = 17056508 | doi = 10.4049/jimmunol.177.9.5840}} 3. ^{{cite journal |vauthors=Barten R, Trowsdale J | title = The human Ly-49L gene | journal = Immunogenetics | volume = 49 | issue = 7-8 | pages = 731–4 |date=July 1999 | pmid = 10369937 | doi = 10.1007/s002510050675}} 4. ^{{cite journal |vauthors=Hao L, Klein J, Nei M | title = Heterogeneous but conserved natural killer receptor gene complexes in four major orders of mammals | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 9 | pages = 3192–7 |date=February 2006 | pmid = 16492762 | pmc = 1413923 | doi = 10.1073/pnas.0511280103 }} External links
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