| 词条 | Kolliphor EL |
| 释义 |
Kolliphor EL, formerly known as Cremophor EL, is the registered trademark of BASF Corp. for its version of polyethoxylated castor oil. It is prepared by reacting 35 moles of ethylene oxide with each mole of castor oil. The resulting product is a mixture (CAS number 61791-12-6): the major component is the material in which the hydroxyl groups of the castor oil triglyceride have ethoxylated with ethylene oxide to form polyethylene glycol ethers. Minor components are the polyethyelene glycol esters of ricinoleic acid, polyethyelene glycols and polyethyelene glycol ethers of glycerol.[1] Kolliphor EL is a synthetic, nonionic surfactant used to stabilize emulsions of nonpolar materials in water. Kolliphor EL is an excipient or additive in drugs. Therapeutically, modern drugs are rarely given in a pure chemical state, so most active ingredients are combined with excipients or additives such as Kolliphor EL.[2] Uses
Side effectsAllergic reactions to Taxol are most often allergic reactions to Kolliphor EL; symptoms include tightness in the chest, shortness of breath, and similar reactions consistent with severe anaphylactic reactions. Although many anti-allergens including corticosteroids and Benadryl may be administered before chemotherapy, they are not always sufficient to prevent the severe reaction to Kolliphor EL. Note that these should not be confused with the normal side effects of Taxol. The allergic reaction is usually immediate and is similar to severe allergic reactions of many other substances that trigger allergic reactions. See also
References1. ^{{cite web |title=BASF Technical data sheet on Kolliphor EL|url=http://www.pharma-ingredients.basf.com/Statements/Technical%20Informations/EN/Pharma%20Solutions/EMP%20030711e_Cremophor%20EL.pdf|accessdate=2010-12-16}} {{DEFAULTSORT:Cremophor El}}{{Pharma-stub}}2. ^{{cite web | title=A new Steroid Anaesthetic - Althesin | url=http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1645602&blobtype=pdf | format=pdf| publisher=PubMed | accessdate=2007-01-07}} See page 1/49, Methods and Materials. 1 : Excipients |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。