KSFX may refer to:

• KSFX (AM), a radio station (1230 AM) licensed to Roswell, New Mexico, United States
• KOZL-TV, a television station (channel 27) licensed to Springfield, Missouri, United States, which held the call sign KSFX-TV from 2005–2011
• KZDB, a radio station (100.5 FM) licensed to Roswell, New Mexico, United States, which held the call sign KSFX from 1989 to 2017
• KKSF, a radio station (103.7 FM) licensed to San Francisco, California, United States, which held the call sign KSFX from 1972 to 1982

• Mark Columbo
• Markco Maddox
• Mark Comfort
• Mark Connelly (politician)
• Mark Connolly
• Mark Connolly (footballer)
• Mark Connolly (politician)
• Mark Connolly (Public Official)
• Mark Connolly (public official)
• Mark Conover
• Mark Constantine
• Mark Conway (Australian footballer)
• Mark Cook
• Mark Cook (disambiguation)
• Mark Cooke
• Mark Cook (footballer)
• Mark Coombe
• Mark Coombs
• Mark Cooney
• Mark Cooper (academic)
• Mark Cooper (artist)
• Mark Cooper (footballer born 1967)
• Mark Cooper (footballer born 1968)
• Mark Copani
• Mark Corey (outfielder)