KSMO may refer to:

• The ICAO code for Santa Monica Airport
• KSMO (AM), a radio station (1340 AM) licensed to Salem, Missouri, United States
• KSMO-TV, a television station (channel 62) licensed to Kansas City, Missouri, United States
• KSMO (AM) (San Francisco), a radio station that existed in San Francisco, California, United States at 1550kHz from 1947 to 1952 and broadcast classical music; the call letters were changed to KEAR in 1952
• KSMO (Uganda), a notable law firm in Uganda.

• Hensley Paulina
• Hensley Settlement (Kentucky)
• Henslow, John
• Henslow peaclam
• Hensodon spinosus
• Hensoldt GmbH
• Henson Branch
• Henson, Brian
• Henson Creek
• Henson, David
• Henson Glacier (Greenland)
• Henson Gletscher
• Henson graph
• Henson, Maria
• Henson, Matthew
• Henson, Missouri
• Henson, Richard
• Henson School of Science and Technology
• Henson Springs, Alabama
• Henson, Steve
• Henson (surname)
• Henson v. Santander
• Henson v. Santander Consumer USA Inc.
• Henson, William
• Henssler Capital LLC