La 1, LA 1 or LA-1 may refer to:

• Louisiana Highway 1, a state highway in Louisiana
• Louisiana State Route 1, a former state highway in Louisiana, also known as the Jefferson Highway
• Louisiana's 1st congressional district, an American congressional district

In broadcasting:

• La 1 (Spanish TV channel), a Spanish TV channel
• RSI La 1, a Swiss Italian-language TV channel

• Poly((1-4)-beta-D-mannuronide) lyase
• Poly-4-vinylphenol
• PolyA+
• Poly(A+)
• Poly(a) binding protein interacting protein 2b
• Polyacanthia femoralis
• Polyacanthia flavipes
• Polyacanthia fonscolombei
• Polyacanthia fonscolombei fonscolombei
• Polyacanthia fonscolombei hebridarum
• Polyacanthia medialis
• Polyacanthia simplex
• Polyacanthia stictica
• Polyacanthia strandi
• Polyacanthia trifolium
• Polyacanthorhynchidae
• Polyacanthus hasselti
• Polyacanthus signatus
• Polyachyrus poeppigii
• Polyacrylates
• Poly adenine tail
• Poly-adenosine tail
• Polyadenosine tail
• Polyadenum sinensis
• Polyadenylated