| 词条 | Leaky gut syndrome |
| 释义 |
Unlike the scientific phenomenon of increased intestinal permeability ("leaky gut"),[1][1] claims for the existence of "leaky gut syndrome" as a distinct medical condition come mostly from nutritionists and practitioners of alternative medicine.[1][5][6] Proponents claim that a "leaky gut" causes chronic inflammation throughout the body that results in a wide range of conditions, including chronic fatigue syndrome, rheumatoid arthritis, lupus, migraines, multiple sclerosis, and autism.[1][2] {{asof|2016}}, there is little evidence to support the hypothesis that leaky gut syndrome directly causes this wide array of diseases.[1][3] Stephen Barrett has described "leaky gut syndrome" as a fad diagnosis and says that its proponents use the alleged condition as an opportunity to sell a number of alternative-health remedies – including diets, herbal preparations, and dietary supplements.[4] In 2009 Seth Kalichman wrote that some pseudoscientists claim that the passage of proteins through a "leaky" gut is the cause of autism.[5] The belief that a "leaky gut" might actually cause autism is popular among the public, but the evidence is weak and what evidence exists is conflicting.[6]Advocates tout various treatments for "leaky gut syndrome", such as dietary supplements, probiotics, herbal remedies, gluten-free foods, and low-FODMAP, low-sugar, or antifungal diets, but there is little evidence that the treatments offered are of benefit.[7] None have been adequately tested to determine if they are safe and effective for this purpose.[2] The U.K. National Institute for Health and Care Excellence (NICE) does not recommend the use of special diets to manage the main symptoms of autism.[7] See also
References1. ^{{cite journal| vauthors= Bischoff SC, Barbara G, Buurman W, Ockhuizen T, Schulzke JD, Serino M et al.| title= Intestinal permeability--a new target for disease prevention and therapy. | journal= BMC Gastroenterol | year= 2014 | volume= 14 | issue= | pages= 189 | pmid= 25407511 | doi= 10.1186/s12876-014-0189-7 | pmc= 4253991 | type= Review }} {{Pseudoscience}}2. ^1 2 {{cite journal|doi= 10.1016/j.cgh.2013.07.001|title= Intestinal Permeability Defects: Is It Time to Treat?|year= 2013|last1= Odenwald|first1= Matthew A.|last2= Turner|first2= Jerrold R.|journal= Clinical Gastroenterology and Hepatology|volume= 11|issue= 9|pages= 1075–83|pmid= 23851019|pmc= 3758766}} 3. ^{{cite journal| author=Quigley EM| title=Leaky gut - concept or clinical entity? | journal=Curr Opin Gastroenterol | year= 2016 | volume= 32 | issue= 2 | pages= 74–9 | pmid=26760399 | doi=10.1097/MOG.0000000000000243 | url=https://journals.lww.com/co-gastroenterology/Abstract/2016/03000/Leaky_gut___concept_or_clinical_entity_.4.aspx |type=Review }} 4. ^1 {{cite web|url= http://www.quackwatch.com/01QuackeryRelatedTopics/fad.html|title= Be Wary of "Fad" Diagnoses|last= Barrett|first= Stephen|authorlink = Stephen Barrett|date= 14 March 2009|work= Quackwatch|accessdate= 24 October 2013}} 5. ^{{cite book|first= Seth C.|last= Kalichman|title= Denying AIDS: Conspiracy Theories, Pseudoscience, and Human Tragedy|year= 2009|publisher= Springer|isbn= 9780387794761|page= [https://books.google.com/books?id=_mtDBCDwxugC&pg=PA167 167]}} 6. ^{{cite journal| vauthors= Rao M, Gershon MD| title= The bowel and beyond: the enteric nervous system in neurological disorders | journal= Nat Rev Gastroenterol Hepatol | year= 2016 | volume= 13 | issue= 9 | pages= 517–28 | pmid= 27435372 | doi= 10.1038/nrgastro.2016.107 | url= http://www.nature.com/nrgastro/journal/v13/n9/full/nrgastro.2016.107.html | type= Review | pmc= 5005185}} 7. ^1 2 3 4 5 6 {{cite web|url= http://www.nhs.uk/conditions/leaky-gut-syndrome/|title= Leaky gut syndrome|date= 26 February 2015|publisher= NHS Choices|accessdate= 15 August 2016}} 6 : Pseudoscience|Alternative diagnoses|Alternative medicine|Health fraud|Gastroenterology|Syndromes |
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