| 释义 |
- Interactions
- References
- Further reading
- External links
{{Infobox_gene}}Leucyl/cystinyl aminopeptidase, also known as cystinyl aminopeptidase (CAP), insulin-regulated aminopeptidase (IRAP), human placental leucine aminopeptidase (PLAP), oxytocinase, and vasopressinase, is an enzyme of the aminopeptidase group that in humans is encoded by the LNPEP gene.[1][2]This gene encodes a zinc-dependent aminopeptidase (metalloexopeptidase) that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms.[2] Mutations in this gene have been associated to psoriasis risk.(doi:10.1038/jid.2013.317) InteractionsCystinyl aminopeptidase has been shown to interact with TNKS2.[3][4][5] References1. ^{{cite journal |vauthors=Rogi T, Tsujimoto M, Nakazato H, Mizutani S, Tomoda Y | title = Human placental leucine aminopeptidase/oxytocinase. A new member of type II membrane-spanning zinc metallopeptidase family | journal = J Biol Chem | volume = 271 | issue = 1 | pages = 56–61 |date=February 1996 | pmid = 8550619 | pmc = | doi = 10.1074/jbc.271.1.56}}
2. ^1 {{cite web | title = Entrez Gene: LNPEP leucyl/cystinyl aminopeptidase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4012| accessdate = }}
3. ^{{cite journal |last=Sbodio |first=Juan I |authorlink= |author2=Chi Nai-Wen |date=August 2002 |title=Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner |journal=J. Biol. Chem. |volume=277 |issue=35 |pages=31887–92 | issn = 0021-9258| pmid = 12080061 |doi = 10.1074/jbc.M203916200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
4. ^{{cite journal |last=Chi |first=N W |authorlink= |author2=Lodish H F |date=December 2000 |title=Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles |journal=J. Biol. Chem. |volume=275 |issue=49 |pages=38437–44 | issn = 0021-9258| pmid = 10988299 |doi = 10.1074/jbc.M007635200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
5. ^{{cite journal |last=Sbodio |first=Juan I |authorlink= |author2=Lodish Harvey F |author3=Chi Nai-Wen |date=February 2002 |title=Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase) |journal=Biochem. J. |volume=361 |issue=Pt 3 |pages=451–9 | issn = 0264-6021| pmid = 11802774 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1042/0264-6021:3610451 |pmc=1222327 }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Albiston AL, Mustafa T, McDowall SG |title=AT4 receptor is insulin-regulated membrane aminopeptidase: potential mechanisms of memory enhancement. |journal=Trends Endocrinol. Metab. |volume=14 |issue= 2 |pages= 72–7 |year= 2003 |pmid= 12591177 |doi=10.1016/S1043-2760(02)00037-1 |display-authors=etal}}
- {{cite journal | author=Keller SR |title=The insulin-regulated aminopeptidase: a companion and regulator of GLUT4. |journal=Front. Biosci. |volume=8 |issue= 6|pages= s410–20 |year= 2004 |pmid= 12700100 |doi=10.2741/1078 }}
- {{cite journal | author=Keller SR |title=Role of the insulin-regulated aminopeptidase IRAP in insulin action and diabetes. |journal=Biol. Pharm. Bull. |volume=27 |issue= 6 |pages= 761–4 |year= 2005 |pmid= 15187412 |doi=10.1248/bpb.27.761 |url=https://zenodo.org/record/940104/files/article.pdf }}
- {{cite journal |vauthors=Nomura S, Ito T, Yamamoto E |title=Gene regulation and physiological function of placental leucine aminopeptidase/oxytocinase during pregnancy. |journal=Biochim. Biophys. Acta |volume=1751 |issue= 1 |pages= 19–25 |year= 2005 |pmid= 15894523 |doi= 10.1016/j.bbapap.2005.04.006 |display-authors=etal}}
- {{cite journal |vauthors=Tsujimoto M, Hattori A |title=The oxytocinase subfamily of M1 aminopeptidases. |journal=Biochim. Biophys. Acta |volume=1751 |issue= 1 |pages= 9–18 |year= 2005 |pmid= 16054015 |doi= 10.1016/j.bbapap.2004.09.011 }}
- {{cite journal |vauthors=Mizutani S, Shibata K, Kikkawa F |title=Essential role of placental leucine aminopeptidase in gynecologic malignancy. |journal=Expert Opin. Ther. Targets |volume=11 |issue= 4 |pages= 453–61 |year= 2007 |pmid= 17373876 |doi= 10.1517/14728222.11.4.453 |display-authors=etal}}
- {{cite journal |vauthors=Tsujimoto M, Mizutani S, Adachi H |title=Identification of human placental leucine aminopeptidase as oxytocinase. |journal=Arch. Biochem. Biophys. |volume=292 |issue= 2 |pages= 388–92 |year= 1992 |pmid= 1731608 |doi=10.1016/0003-9861(92)90007-J |display-authors=etal}}
- {{cite journal |vauthors=Mizutani S, Akiyama H, Kurauchi O |title=In vitro degradation of angiotensin II (A-II) by human placental subcellular fractions, pregnancy sera and purified placental aminopeptidases. |journal=Acta Endocrinol. |volume=110 |issue= 1 |pages= 135–9 |year= 1985 |pmid= 3898693 |doi= 10.1530/acta.0.1100135|display-authors=etal}}
- {{cite journal |vauthors=Beckman L, Björling G, Christodoulou C |title=Pregnancy enzymes and placental polymorphism. II. Leucine aminopeptidase. |journal=Acta Genetica et Statistica Medica |volume=16 |issue= 2 |pages= 122–31 |year= 1966 |pmid= 5953194 |doi= 10.1159/000151957}}
- {{cite journal |vauthors=Itoh C, Watanabe M, Nagamatsu A |title=Two molecular species of oxytocinase (L-cystine aminopeptidase) in human placenta: purification and characterization. |journal=Biol. Pharm. Bull. |volume=20 |issue= 1 |pages= 20–4 |year= 1997 |pmid= 9013800 |doi= 10.1248/bpb.20.20|display-authors=etal}}
- {{cite journal |vauthors=Laustsen PG, Rasmussen TE, Petersen K |title=The complete amino acid sequence of human placental oxytocinase. |journal=Biochim. Biophys. Acta |volume=1352 |issue= 1 |pages= 1–7 |year= 1997 |pmid= 9177475 |doi= 10.1016/S0167-4781(97)00036-5|display-authors=etal}}
- {{cite journal |vauthors=Nagasaka T, Nomura S, Okamura M |title=Immunohistochemical localization of placental leucine aminopeptidase/oxytocinase in normal human placental, fetal and adult tissues. |journal=Reprod. Fertil. Dev. |volume=9 |issue= 8 |pages= 747–53 |year= 1998 |pmid= 9733056 |doi=10.1071/R97055 |display-authors=etal}}
- {{cite journal |vauthors=Horio J, Nomura S, Okada M |title=Structural organization of the 5'-end and chromosomal assignment of human placental leucine aminopeptidase/insulin-regulated membrane aminopeptidase gene. |journal=Biochem. Biophys. Res. Commun. |volume=262 |issue= 1 |pages= 269–74 |year= 1999 |pmid= 10448104 |doi= 10.1006/bbrc.1999.1184 |display-authors=etal}}
- {{cite journal |vauthors=Rasmussen TE, Pedraza-Díaz S, Hardré R |title=Structure of the human oxytocinase/insulin-regulated aminopeptidase gene and localization to chromosome 5q21. |journal=Eur. J. Biochem. |volume=267 |issue= 8 |pages= 2297–306 |year= 2000 |pmid= 10759854 |doi=10.1046/j.1432-1327.2000.01234.x |display-authors=etal}}
- {{cite journal |vauthors=Nakanishi Y, Nomura S, Okada M |title=Immunoaffinity purification and characterization of native placental leucine aminopeptidase/oxytocinase from human placenta. |journal=Placenta |volume=21 |issue= 7 |pages= 628–34 |year= 2001 |pmid= 10985965 |doi= 10.1053/plac.2000.0564 |display-authors=etal}}
- {{cite journal |vauthors=Chi NW, Lodish HF |title=Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles. |journal=J. Biol. Chem. |volume=275 |issue= 49 |pages= 38437–44 |year= 2001 |pmid= 10988299 |doi= 10.1074/jbc.M007635200 }}
- {{cite journal |vauthors=Matsumoto H, Nagasaka T, Hattori A |title=Expression of placental leucine aminopeptidase/oxytocinase in neuronal cells and its action on neuronal peptides. |journal=Eur. J. Biochem. |volume=268 |issue= 11 |pages= 3259–66 |year= 2001 |pmid= 11389728 |doi=10.1046/j.1432-1327.2001.02221.x |display-authors=etal}}
- {{cite journal |vauthors=Iwase A, Nomura S, Mizutani S |title=Characterization of a secretase activity for placental leucine aminopeptidase. |journal=Arch. Biochem. Biophys. |volume=393 |issue= 1 |pages= 163–9 |year= 2001 |pmid= 11516173 |doi= 10.1006/abbi.2001.2489 }}
- {{cite journal |vauthors=Ito T, Nomura S, Okada M |title=Transcriptional regulation of human placental leucine aminopeptidase/oxytocinase gene. |journal=Mol. Hum. Reprod. |volume=7 |issue= 9 |pages= 887–94 |year= 2001 |pmid= 11517297 |doi=10.1093/molehr/7.9.887 |display-authors=etal}}
{{refend}}External links- The MEROPS online database for peptidases and their inhibitors: M01.011
- {{MeshName|Cystinyl+aminopeptidase}}
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