| 词条 | Leu-enkephalin |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 442009113 | ImageFile=leu-enkaphalin.png | ImageSize=300px | IUPACName=(2R)-2-[[(2R)-2-[[2-[[2-[[(2R)-2-amino-3- | OtherNames= |Section1={{Chembox Identifiers | PubChem = 461776 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 406229 | SMILES = O=C(O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)Cc2ccccc2)CC(C)C | InChI = 1/C28H37N5O7/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40)/t21-,22-,23-/m0/s1 | InChIKey = URLZCHNOLZSCCA-VABKMULXBR | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C28H37N5O7/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40)/t21-,22-,23-/m0/s1 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = URLZCHNOLZSCCA-VABKMULXSA-N | CASNo_Ref = {{cascite|correct|CAS}} | CASNo=58822-25-6 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 8234 | IUPHAR_ligand = 1613 }} |Section2={{Chembox Properties | Formula= C28H37N5O7 | MolarMass=555.62 g/mol[1] | MeltingPt= | BoilingPt= | Solubility= |Section3={{Chembox Hazards | MainHazards= | FlashPt= | AutoignitionPt = }}Leu-enkephalin is an endogenous opioid peptide neurotransmitter with the amino acid sequence Tyr-Gly-Gly-Phe-Leu that is found naturally in the brains of many animals, including humans.[2][3] It is one of the two forms of enkephalin; the other is met-enkephalin.[2] The tyrosine residue at position 1 is thought to be analogous to the 3-hydroxyl group on morphine.[4] Leu-enkephalin has agonistic actions at both the μ- and δ-opioid receptors, with significantly greater preference for the latter. It has little to no effect on the κ-opioid receptor.[5][6] See also
References1. ^{{cite journal | vauthors = Colaianni L, Kung SC, Taggart DK, Picca RA, Greaves J, Penner RM, Cioffi N | title = Reduction of spectral interferences using ultraclean gold nanowire arrays in the LDI-MS analysis of a model peptide | journal = Analytical and Bioanalytical Chemistry | volume = 406 | issue = 19 | pages = 4571–83 | date = July 2014 | pmid = 24980599 | doi = 10.1007/s00216-014-7876-7 }} {{Neuropeptides}}{{Opioidergics}}{{biochemistry-stub}}2. ^1 {{cite journal | vauthors = Lazarus LH, Ling N, Guillemin R | title = beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and enkephalins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 73 | issue = 6 | pages = 2156–9 | date = June 1976 | pmid = 1064883 | pmc = 430469 | doi = }} 3. ^{{cite journal | vauthors = Hughes J, Kosterlitz HW, Smith TW | title = The distribution of methionine-enkephalin and leucine-enkephalin in the brain and peripheral tissues. 1977 | journal = British Journal of Pharmacology | volume = 120 | issue = 4 Suppl | pages = 428–36; discussion 426–7 | date = February 1997 | pmid = 9142421 | pmc = 3224324 | doi = }} 4. ^{{cite journal | vauthors = Schiller PW, Yam CF, Lis M | title = Evidence for topographical analogy between methionine-enkephalin and morphine derivatives | journal = Biochemistry | volume = 16 | issue = 9 | pages = 1831–8 | date = May 1977 | pmid = 870028 }} 5. ^{{cite journal | vauthors = Porreca F, Mosberg HI, Hurst R, Hruby VJ, Burks TF | title = Roles of mu, delta and kappa opioid receptors in spinal and supraspinal mediation of gastrointestinal transit effects and hot-plate analgesia in the mouse | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 230 | issue = 2 | pages = 341–8 | date = August 1984 | pmid = 6086883 }} 6. ^{{cite journal | vauthors = Raynor K, Kong H, Chen Y, Yasuda K, Yu L, Bell GI, Reisine T | title = Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors | journal = Molecular Pharmacology | volume = 45 | issue = 2 | pages = 330–4 | date = February 1994 | pmid = 8114680 }} 2 : Delta-opioid agonists|Opioid peptides |
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