| 词条 | Leukotriene B4 |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 416501457 | ImageFile = Leukotriene B4.svg | ImageSize = | IUPACName = (5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxy-6,8,10,14-icosatetraenoic acid | OtherNames = |Section1={{Chembox Identifiers | IUPHAR_ligand = 2487 | Abbreviations = | CASNo_Ref = {{cascite|correct|??}} | CASNo = 71160-24-2 | EINECS = | PubChem = 5280492 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 4444132 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 65061 | SMILES = CCCCC/C=C\\C[C@H](/C=C/C=C/C=C\\[C@H](CCCC(=O)O)O)O | InChI = 1/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 | InChIKey = VNYSSYRCGWBHLG-AMOLWHMGBE | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = VNYSSYRCGWBHLG-AMOLWHMGSA-N | RTECS = | MeSHName = | ChEBI_Ref = {{ebicite|changed|EBI}} | ChEBI = 15647 | KEGG_Ref = {{keggcite|changed|kegg}} | KEGG = C02165 }} |Section2={{Chembox Properties | Formula = C20H32O4 | MolarMass = 336.466 | Appearance = | Density = | MeltingPt = | MeltingPt_notes = | BoilingPt = | BoilingPt_notes = | Solubility = | SolubleOther = | Solvent = | pKa = | pKb = |Section7={{Chembox Hazards | ExternalSDS = | EUClass = | MainHazards = | NFPA-H = | NFPA-F = | NFPA-R = | NFPA-S = | RPhrases = | SPhrases = | RSPhrases = | FlashPt = | AutoignitionPt = | ExploLimits = | PEL = }} Leukotriene B4 (LTB4) is a leukotriene involved in inflammation. It has been shown to promote insulin resistance in obese mice. BiochemistryLeukotriene B4 (LTB4) is a leukotriene involved in inflammation. It is produced from leukocytes in response to inflammatory mediators and is able to induce the adhesion and activation of leukocytes on the endothelium, allowing them to bind to and cross it into the tissue.[1] In neutrophils, it is also a potent chemoattractant, and is able to induce the formation of reactive oxygen species and the release of lysosomal enzymes by these cells.[1] It is synthesized by leukotriene-A4 hydrolase from leukotriene A4.[2] DiabetesA study at the University of California, San Diego School of Medicine has shown that leukotriene B4 promotes insulin resistance in obese mice.[3] Obesity is the major cause of type 2 diabetes insulin resistance.[4] References1. ^1 {{cite book | title=Robbins Pathologic Basis of Disease| last=Cotran|author2=Kumar, Collins | publisher=W.B Saunders Company| location=Philadelphia| isbn=0-7216-7335-X}} {{Leukotrienes}}{{Leukotriene signaling modulators}}{{PPAR modulators}}{{biochemistry-stub}}2. ^{{cite web|url=https://www.uniprot.org/uniprot/P09960|accessdate=9 April 2013}} 3. ^[https://health.ucsd.edu/news/releases/Pages/2015-02-23-type-2-diabetes-and-obesity-molecular-link.aspx UCSanDiego Press Release] 4. ^{{cite journal|journal=Nature Medicine|title=LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes|volume=21|date=2015|pages=239–247|doi=10.1038/nm.3800|pmid=25706874 | last1 = Li | first1 = P | last2 = Oh | first2 = DY | last3 = Bandyopadhyay | first3 = G | last4 = Lagakos | first4 = WS | last5 = Talukdar | first5 = S | last6 = Osborn | first6 = O | last7 = Johnson | first7 = A | last8 = Chung | first8 = H | last9 = Maris | first9 = M | last10 = Ofrecio | first10 = JM | last11 = Taguchi | first11 = S | last12 = Lu | first12 = M | last13 = Olefsky | first13 = JM| pmc = 4429798 }} 1 : Eicosanoids |
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