| 释义 |
- See also
- References
- Further reading
- External links
{{DISPLAYTITLE:Leukotriene B4 receptor 1}}{{Infobox_gene}}Leukotriene B4 receptor 1 is a protein that in humans is encoded by the LTB4R gene.[1][2][3]See also- Eicosanoid receptor
- Etalocib, an antagonist at the leukotriene B4 receptor
References1. ^{{cite journal |vauthors=Owman C, Nilsson C, Lolait SJ | title = Cloning of cDNA encoding a putative chemoattractant receptor | journal = Genomics | volume = 37 | issue = 2 | pages = 187–94 |date=Feb 1997 | pmid = 8921391 | pmc = | doi = 10.1006/geno.1996.0541 }}
2. ^{{cite journal |vauthors=Akbar GK, Dasari VR, Webb TE, Ayyanathan K, Pillarisetti K, Sandhu AK, Athwal RS, Daniel JL, Ashby B, Barnard EA, Kunapuli SP | title = Molecular cloning of a novel P2 purinoceptor from human erythroleukemia cells | journal = J Biol Chem | volume = 271 | issue = 31 | pages = 18363–7 |date=Sep 1996 | pmid = 8702478 | pmc = | doi =10.1074/jbc.271.31.18363 }}
3. ^{{cite web | title = Entrez Gene: LTB4R leukotriene B4 receptor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1241| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Raport CJ, Schweickart VL, Chantry D, etal |title=New members of the chemokine receptor gene family. |journal=J. Leukoc. Biol. |volume=59 |issue= 1 |pages= 18–23 |year= 1996 |pmid= 8558062 |doi= }}
- {{cite journal |vauthors=Tager AM, Luster AD |title=BLT1 and BLT2: the leukotriene B(4) receptors. |journal=Prostaglandins Leukot. Essent. Fatty Acids |volume=69 |issue= 2-3 |pages= 123–34 |year= 2004 |pmid= 12895595 |doi=10.1016/S0952-3278(03)00073-5 }}
- {{cite journal |vauthors=Miyahara N, Miyahara S, Takeda K, Gelfand EW |title=Role of the LTB4/BLT1 pathway in allergen-induced airway hyperresponsiveness and inflammation. |journal=Allergology International |volume=55 |issue= 2 |pages= 91–7 |year= 2006 |pmid= 17075244 |doi= 10.2332/allergolint.55.91 }}
- {{cite journal |vauthors=Hillier LD, Lennon G, Becker M, etal |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=10.1101/gr.6.9.807 }}
- {{cite journal |vauthors=Yokomizo T, Izumi T, Chang K, etal |title=A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. |journal=Nature |volume=387 |issue= 6633 |pages= 620–4 |year= 1997 |pmid= 9177352 |doi= 10.1038/42506 }}
- {{cite journal |vauthors=Maier R, Glatz A, Mosbacher J, Bilbe G |title=Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues. |journal=Biochem. Biophys. Res. Commun. |volume=237 |issue= 2 |pages= 297–302 |year= 1997 |pmid= 9268704 |doi= 10.1006/bbrc.1997.7135 }}
- {{cite journal |vauthors=Gaudreau R, Le Gouill C, Métaoui S, etal |title=Signalling through the leukotriene B4 receptor involves both alphai and alpha16, but not alphaq or alpha11 G-protein subunits. |journal=Biochem. J. |volume=335 |issue= 1|pages= 15–8 |year= 1998 |pmid= 9742207 |doi= | pmc=1219746 }}
- {{cite journal |vauthors=Kato K, Yokomizo T, Izumi T, Shimizu T |title=Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene. |journal=J. Exp. Med. |volume=192 |issue= 3 |pages= 413–20 |year= 2000 |pmid= 10934229 |doi=10.1084/jem.192.3.413 | pmc=2193224 }}
- {{cite journal |vauthors=Yokomizo T, Kato K, Terawaki K, etal |title=A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders. |journal=J. Exp. Med. |volume=192 |issue= 3 |pages= 421–32 |year= 2000 |pmid= 10934230 |doi=10.1084/jem.192.3.421 | pmc=2193217 }}
- {{cite journal |vauthors=Stankova J, Turcotte S, Harris J, Rola-Pleszczynski M |title=Modulation of leukotriene B4 receptor-1 expression by dexamethasone: potential mechanism for enhanced neutrophil survival. |journal=J. Immunol. |volume=168 |issue= 7 |pages= 3570–6 |year= 2002 |pmid= 11907121 |doi= 10.4049/jimmunol.168.7.3570}}
- {{cite journal |vauthors=Gaudreau R, Le Gouill C, Venne MH, etal |title=Threonine 308 within a putative casein kinase 2 site of the cytoplasmic tail of leukotriene B(4) receptor (BLT1) is crucial for ligand-induced, G-protein-coupled receptor-specific kinase 6-mediated desensitization. |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 31567–76 |year= 2002 |pmid= 12077128 |doi= 10.1074/jbc.M202723200 }}
- {{cite journal |vauthors=Hennig R, Ding XZ, Tong WG, etal |title=5-Lipoxygenase and leukotriene B(4) receptor are expressed in human pancreatic cancers but not in pancreatic ducts in normal tissue. |journal=Am. J. Pathol. |volume=161 |issue= 2 |pages= 421–8 |year= 2002 |pmid= 12163367 |doi= 10.1016/S0002-9440(10)64198-3| pmc=1850753 }}
- {{cite journal |vauthors=Ito N, Yokomizo T, Sasaki T, etal |title=Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release. |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 44898–904 |year= 2003 |pmid= 12244116 |doi= 10.1074/jbc.M208051200 }}
- {{cite journal |vauthors=Tong WG, Ding XZ, Hennig R, etal |title=Leukotriene B4 receptor antagonist LY293111 inhibits proliferation and induces apoptosis in human pancreatic cancer cells. |journal=Clin. Cancer Res. |volume=8 |issue= 10 |pages= 3232–42 |year= 2003 |pmid= 12374694 |doi= }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Yokomizo T, Noiri E, Izumi T, Shimizu T |title=In vivo chemotaxis using CHO cells expressing human leukotriene B4 receptor. |journal=Adv. Exp. Med. Biol. |volume=507 |issue= |pages= 357–61 |year= 2003 |pmid= 12664610 |doi= 10.1007/978-1-4615-0193-0_55}}
{{refend}}External links- {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2340 | title = Leukotriene Receptors: BLT1 | accessdate = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}
- {{MeshName|LTB4R+protein,+human}}
- {{MeshName|Receptors,+Leukotriene+B4}}
{{NLM content}}{{G protein-coupled receptors}}{{transmembranereceptor-stub}} 1 : G protein-coupled receptors |