| City | Country | IATA | ICAO | Airport | Refs |
|---|
| Barranquilla | Colombia | BAQ | SKBQ | Ernesto Cortissoz International Airport |
| Bogota | Colombia | BOG | SKBO | El Dorado International Airport |
| Bucaramanga | Colombia | BGA | SKBG | Palonegro International Airport |
| Cali | Colombia | CLO | SKCL | Alfonso Bonilla Aragón International Airport |
| Cancún | Mexico | CUN | MMUN | Cancún International Airport |
| Caracas | Venezuela | CCS | SVMI | Simon Bolivar International Airport |
| Cartagena | Colombia | CTG | SKCG | Rafael Núñez International Airport |
| Cartago | Colombia | CRC | SKGO | Santa Ana Airport |
| Cúcuta | Colombia | CUC | SKCC | Camilo Daza International Airport | |
| Havana | Cuba | HAV | MUHA | José Martí International Airport |
| Leticia | Colombia | LET | SKLT | Alfredo Vásquez Cobo International Airport |
| Medellín | Colombia | MDE | SKRG | José María Córdova International Airport |
| Mexico City | Mexico | MEX | MMMX | Mexico City International Airport |
| Montería | Colombia | MTR | SKMR | Los Garzones Airport |
| Oranjestad | Aruba | AUA | TNCA | Reina Beatrix International Airport |
| Panama City | Panama | PTY | MPTO | Tocumen International Airport |
| Porlamar | Venezuela | PMV | SVMG | Del Caribe "Santiago Mariño" International Airport |
| Punta Cana | Dominican Republic | PUJ | MDPC | Punta Cana International Airport |
| Guatemala | Guatemala | GUA | MGGT | La Aurora International Airport |
| Quito | Ecuador | UIO | SEQM | Mariscal Sucre International Airport |
| San Andrés | Colombia | ADZ | SKSP | Gustavo Rojas Pinilla International Airport |
| San Pedro Sula | Honduras | SAP | MHLM | Ramón Villeda Morales International Airport |
| Santa Marta | Colombia | SMR | SKSM | Simon Bolivar International Airport |
| Santo Domingo | Dominican Republic | SDQ | MDSD | Las Américas International Airport |
1. ^{{cite web |url=http://www.copaair.com/Sites/cc/es/Informacion-de-viaje/Pages/Mapa-de-Rutas.aspx |title=Archived copy |accessdate=2010-10-07 |deadurl=yes |archiveurl=https://web.archive.org/web/20101018064102/http://www.copaair.com/Sites/cc/es/Informacion-de-viaje/Pages/Mapa-de-Rutas.aspx |archivedate=18 October 2010 |df=dmy-all }}
{{DEFAULTSORT:Copa Airlines Colombia Destinations}}