These hits topped the Dutch Top 40 in 2001 (see 2001 in music).
| Issue Date | Artist | Song | | 6 January | LeAnn Rimes | Can't Fight the Moonlight |
| 13 January | LeAnn Rimes | Can't Fight the Moonlight |
| 20 January | Jennifer Lopez | Love Don't Cost a Thing |
| 27 January | Jennifer Lopez | Love Don't Cost a Thing |
| 3 February | Outkast | Ms. Jackson |
| 10 February | Netherlands}} | Puf / Schudden |
| 17 February | Def Rhymz | Puf / Schudden |
| 24 February | Shaggy & Rikrok | It Wasn't Me |
| 3 March | Shaggy & Rikrok | It Wasn't Me |
| 10 March | Shaggy & Rikrok | It Wasn't Me |
| 17 March | Shaggy & Rikrok | It Wasn't Me |
| 24 March | Shaggy & Rikrok | It Wasn't Me |
| 31 March | Shaggy & Rikrok | It Wasn't Me |
| 7 April | Shaggy & Rikrok | It Wasn't Me |
| 14 April | Starmaker | Damn (I Think I Love You) |
| 21 April | Starmaker | Damn (I Think I Love You) |
| 28 April | Starmaker | Damn (I Think I Love You) |
| 5 May | Starmaker | Damn (I Think I Love You) |
| 12 May | Starmaker | Damn (I Think I Love You) |
| 19 May | One Day Fly | I Wanna Be a One Day Fly |
| 26 May | One Day Fly | I Wanna Be a One Day Fly |
| 2 June | One Day Fly | I Wanna Be a One Day Fly |
| 9 June | One Day Fly | I Wanna Be a One Day Fly |
| 16 June | Atomic Kitten | Whole Again |
| 23 June | Shaggy & Rayvon | Angel |
| 30 June | Shaggy & Rayvon | Angel |
| 7 July | Shaggy & Rayvon | Angel |
| 14 July | Shaggy & Rayvon | Angel |
| 21 July | Shaggy & Rayvon | Angel |
| 28 July | Shaggy & Rayvon | Angel |
| 4 August | Shaggy & Rayvon | Angel |
| 11 August | U2 | Elevation |
| 18 August | Netherlands}} | My Way |
| 25 August | Herman Brood | My Way |
| 1 September | Dante Thomas | Miss California |
| 8 September | Alicia Keys | Fallin' |
| 15 September | Alicia Keys | Fallin |
| 22 September | Alicia Keys | Fallin |
| 29 September | Alicia Keys | Fallin |
| 6 October | Kylie Minogue | Can't Get You Out of My Head |
| 13 October | Kylie Minogue | Can't Get You Out of My Head |
| 20 October | Kylie Minogue | Can't Get You Out of My Head |
| 27 October | Kylie Minogue | Can't Get You Out of My Head |
| 3 November | Kylie Minogue | Can't Get You Out of My Head |
| 10 November | Kylie Minogue | Can't Get You Out of My Head |
| 17 November | De Poema's | Zij maakt het verschil |
| 24 November | De Poema's | Zij maakt het verschil |
| 1 December | Netherlands}} | Happy |
| 8 December | Sita | Happy |
| 15 December | Gigi d'Agostino | L'amour toujours |
| 22 December | Gigi d'Agostino | L'amour toujours |
| 29 December | Gigi d'Agostino | L'amour toujours |
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