1. ^David H. Clark. Died in office March 7, 1891
2. ^Frank L. Boyce. Died in office December 19, 1896.
3. ^Martin E. Rudolph. Died in office March 28, 1903.
4. ^R. H. McCaughey. Died in office July 16, 1906.
5. ^Gilbert Thoreson. Died in office May 8, 1910
6. ^James W. Cone. Died in office October 10, 1913
7. ^Walter E. Van Demark. Died in office January 12, 1916.
8. ^Lewis John Larson. Died in office July 18, 1933
9. ^William Wallace Moyes. Died in office in 1930.
10. ^Martin Ingval Larsen. Died in office September 24, 1930.
11. ^Earl P. Flowers. Died in office August 23, 1934.
12. ^James Edwin Williams was elected to the Senate in 1933, but was unable to serve due to illness.
13. ^Mike Feeney. Died in office February 19, 1937.
14. ^Jessie E. Sanders. First woman elected to the South Dakota Senate.
15. ^L. A. Johnson. Resigned in 1957.
16. ^Charles S. Reed. Died in office February 9, 1947
17. ^Merton E. Neubauer. Died in office August 15, 1946.
18. ^V. D. Tidball. Died in office in 1946.
19. ^John Longstaff. Died in office June 3, 1946.
20. ^C. F. Manson. Elected to the Senate in 1947, but unable to serve due to illness.
21. ^Chester E. Solomonson. Died in office r 1952.
22. ^Joe E. Lehmann. Elected to the Senate in 1961, but failed to qualify. Wilbur Foss appointed to fill the vacancy.
23. ^Donald J. Stransky. Resigned in 1961.
24. ^Hagen Kelsey. Resigned in 1963.
25. ^Carroll Fullerton. Died in office October 1, 1961.
26. ^F.B. "Bob" Roberts. Appointed January 7, 1957 to fill the vacancy of L. A. Johnson.
27. ^Wilbur Foss. Appointed January 23, 1961 to fill the vacancy of Joe E. Lehmann. Served during the 38th Session of the Senate, and resigned in 1963.
28. ^Lars Gjesdal. Appointed July 12, 1961 to fill the vacancy of Donald J. Stransky.
29. ^Frank L. Hafner. Appointed November 6, 1961 to fill the vacancy of Carroll Fullerton.
30. ^Rayburn R. Rueb. Appointed September 24, 1963 to fill the vacancy of Wilbur Foss. Served during the 39th Session of the Senate.
31. ^Herbert A. Willoughby. Appointed July 13, 1963 to fill the vacancy of Hagen Kelsey.
32. ^Walter Vincent Nordstrom. Died in office May 29, 1967.
33. ^Robert William Hirsch. Resigned December 1969.
34. ^Clell D. Elwood. Resigned March 1967. Kenneth A. Trask was appointed to serve during the 43rd Session.
35. ^Henry T. Quinn. Appointed August 1, 1967 to fill the vacancy of Walter Vincent Nordstrom.
36. ^William R. Ripp. Appointed December 11, 1969 to fill the vacancy of Robert William Hirsch.
37. ^Kenneth A. Trask. Appointed March 23, 1967 to fill vacancy of Clell Elwood.
38. ^Eldon L. Smith. Died in office. Killed in the Rapid City flood of June 9, 1972.
39. ^Franklin Jay Wallahan. Resigned the summer of 1972.
40. ^Jacob Kunstle. Appointed July 18, 1972 to fill the vacancy of Eldon L. Smith.
41. ^Grace Mickelson. Appointed August 25, 1972 to fill the vacancy of Franklin Wallahan.
42. ^Michael J. O'Connor. Resigned April 1977.
43. ^This individual is the grandfather of Billie H Sutton, legislator starting in 2011
44. ^Mary A. McClure. Resigned April 10, 1989 to become Special Assistant for Intergovernmental Affairs for President George H. W. Bush.
45. ^Marilynn Kelm. Resigned November 1975.
46. ^Jess Tjeerdsma. Died in office August 20, 1977.
47. ^Robert W. Kelly. Resigned in 1976. Harold Mortimer-(D) was appointed for the remainder of the 51st Session.
48. ^Elaine L. McCart. Appointed November 19, 1975 to fill the vacancy of Marilynn Kelm.
49. ^Robert K. Williams. Resigned November 15, 1983. E. C. Pieplow, who served from 1967 to 1976, was appointed November 28, 1983 to fill the vacancy for the 59th Session.
50. ^Jerome "Jerry" Mayer. Appointed May 13, 1977 to fill the vacancy of Michael J. O'Connor.
51. ^Robert "Bob" Lyons. Appointed October 7, 1977 to fill the vacancy of Jess Tjeerdsma.
52. ^David S. Laustsen. Resigned August 11, 1987.
53. ^Jack Manke. Died in office August 12, 1985.
54. ^William R. Taylor. Appointed August 11, 1987 to fill the vacancy of David S. Laustsen.
55. ^James W. Emery. Appointed December 18, 1985 to fill the vacancy of Jack Manke.
56. ^Scott N. Heidepriem. Appointed April 27, 1989 to fill the vacancy of Mary A. McClure.
57. ^Richard B. Negstad. Died in office January 11, 1997.
58. ^Leslie J. Kleven. Died in office April 19, 1995.
59. ^Jim D. Thompson. Served during the 70th, 71st, and 72nd Sessions. Resigned December 31, 1997.
60. ^Kermit Staggers. Served during the 70th through 76th Sessions. Resigned May 20, 2002.
61. ^Arnold M. Brown. Appointed January 22, 1997 to fill the vacancy of Richard B. Negstad.
62. ^Dave Munson. Served during the 72nd through 76th Sessions. Resigned May 12, 2002.
63. ^Dick Hainje. Resigned November 12, 2001. Appointed by President George W. Bush as Regional Director of the Federal Emergency Management Agency for Region VII.
64. ^Marguerite Kleven. Appointed June 9, 1995 to fill the vacancy of her husband Leslie J. Kleven.
65. ^Donald "Don" Brosz. Appointed January 1, 1998 to fill the vacancy of Jim D. Thompson.
66. ^Larry Diedrich. Resigned January 26, 2004 to run for the U.S. House of Representatives. Al Kurtenbach-(R) was appointed January 27, 2004 for the remainder of the 79th Session.
67. ^Dan Sutton. Resigned November 14, 2006. Re-elected to the 82nd and 83rd Sessions November 7, 2006.
68. ^Rebekah A. Cradduck. Appointed December 4, 2001 to fill the vacancy of Dick Hainje.
69. ^Dick M. Kelly. Appointed July 1, 2002 to fill the vacancy of Kermit Staggers.
70. ^Richard E. "Dick" Hagen. Died in office September 22, 2002. Elected to the Senate posthumously.
71. ^Gene G. Abdallah. Appointed July 1, 2002 to fill the vacancy of Dave Munson.
72. ^Mike Jaspers. Appointed January 7, 2003 to fill the vacancy of Mitch Richter, who was elected in 2003 but never served.
73. ^Michael LaPointe. Appointed January 7, 2003 to fill the vacancy of Dick Hagen.
74. ^J. P. Duniphan. Defeated in 2006 Republican Primary by Dennis Schmidt-(R).
75. ^Stan Adelstein. Defeated in 2006 Republican Primary by Elli Schwiesow-(R).
76. ^Scott N. Heidepriem. Previously served 1990–1992 as a Republican from the 5th District.
77. ^Switched from the Democratic to the Republican Party in 2008. Switched back in 2010.
78. ^Appointed by Governor Dennis Daugaard to replace Cooper Garnos after 2011 session.
79. ^Appointed by Governor Dennis Daugaard to replace Russel Olson after 2013 session.
80. ^Appointed by Governor Dennis Daugaard to replace J. Mark Johnston after 2013 session.
81. ^Appointed by Governator Dennis Daugaard to replace Stan Adelstein after 2013 session.