This is a list of the number-one hits of 2006 on FIMI's Italian Singles and Albums Charts.
| Issue date | Song | Artist | Album | Artist | | 6 January | "Hung Up" | Madonna | Buoni o cattivi live Anthology 04.05 | Vasco Rossi |
| 13 January | In direzione ostinata e contraria | Fabrizio De André |
| 20 January | Ovunque proteggi | Vinicio Capossela |
| 27 January | Grazie | Gianna Nannini |
| 3 February | L'arcangelo | Ivano Fossati |
| 10 February | "Teach Me Again" | Tina Turner and Elisa | Grazie | Gianna Nannini |
| 17 February | "Sorry" | Madonna | Calypsos | Francesco De Gregori |
| 24 February | Grazie | Gianna Nannini |
| 3 March | On an Island | David Gilmour |
| 10 March | "I Belong to You (Il Ritmo della Passione)" | Eros Ramazzotti and Anastacia |
| 17 March | "Svegliarsi la mattina" | Zero Assoluto | Both Sides of the Gun | Ben Harper |
| 24 March | Grazie | Gianna Nannini |
| 31 March |
| 7 April |
| 14 April |
| 21 April | The Seeger Sessions | Bruce Springsteen |
| 28 April | Pearl Jam | Pearl Jam |
| 5 May | Stadium Arcadium | Red Hot Chili Peppers |
| 12 May | "Hips Don't Lie" | Shakira featuring Wyclef Jean | Eva contro Eva | Carmen Consoli | |
| 19 May | Stadium Arcadium | Red Hot Chili Peppers |
| 26 May | "Stop! Dimentica" | Tiziano Ferro | Tradimento | Fabri Fibra |
| 2 June | Stadium Arcadium | Red Hot Chili Peppers |
| 9 June | Calma apparente | Eros Ramazzotti |
| 16 June | I'm Going to Tell You a Secret | Madonna |
| 23 June | Nessuno è solo | Tiziano Ferro |
| 30 June | "An Easier Affair" | George Michael |
| 7 July | "Sei parte di me" | Zero Assoluto |
| 14 July | "Siamo una squadra fortissimi" | Checco Zalone |
| 21 July | Nome e cognome | Ligabue |
| 28 July | Grazie | Gianna Nannini |
| 4 August |
| 11 August |
| 18 August | "Sei parte di me" | Zero Assoluto |
| 25 August | A Matter of Life and Death | Iron Maiden |
| 1 September | "Rudebox" | Robbie Williams | Lover of Life, Singer of Songs | Freddie Mercury |
| 8 September | "Sei parte di me" | Zero Assoluto |
| 15 September |
| 22 September | Fly | Zucchero |
| 29 September |
| 6 October |
| 13 October | "Primo appuntamento" | Gigi D'Alessio |
| 20 October | Rudebox | Robbie Williams |
| 27 October | "Martyr" | Depeche Mode | Made in Italy | Gigi D'Alessio |
| 3 November | "Jump" | Madonna | Quelli degli altri tutti qui | Claudio Baglioni |
| 10 November | "The Saints Are Coming" | U2 and Green Day | Io canto | Laura Pausini |
| 17 November |
| 24 November |
| 1 December |
| 8 December |
| 15 December | "Io canto" | Laura Pausini |
| 22 December | Soundtrack '96-'06 | Elisa |
| 29 December | "The Saints Are Coming" | U2 and Green Day | Io canto | Laura Pausini |