“L-methionine (S)-S-oxide reductase”的意思、由来-开放百科全书

词条

L-methionine (S)-S-oxide reductase

释义

References

{{enzyme
| Name = L-methionine (S)-S-oxide reductase
| EC_number = 1.8.4.13
| CAS_number =
| IUBMB_EC_number = 1/8/4/13
| GO_code =
| image =
| width =
| caption =
}}

In enzymology, a L-methionine (S)-S-oxide reductase ({{EC number|1.8.4.13}}) is an enzyme that catalyzes the chemical reaction

L-methionine + thioredoxin disulfide + H₂O L-methionine (S)-S-oxide + thioredoxin

The 3 substrates of this enzyme are L-methionine, thioredoxin disulfide, and H₂O, whereas its two products are L-methionine (S)-S-oxide and thioredoxin.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with a disulfide as acceptor. The systematic name of this enzyme class is L-methionine:thioredoxin-disulfide S-oxidoreductase. Other names in common use include fSMsr, methyl sulfoxide reductase I and II, acetylmethionine sulfoxide reductase, methionine sulfoxide reductase, L-methionine:oxidized-thioredoxin S-oxidoreductase, methionine-S-oxide reductase, and free-methionine (S)-S-oxide reductase. This enzyme participates in methionine metabolism.

References

{{cite journal | vauthors = Black S, Harte EM, Hudson B, Wartofsky L | year = 1960 | title = A specific enzymatic reduction of L-(-)methionine sulfoxide and a related nonspecific reduction of diulfides | journal = J. Biol. Chem. | volume = 235 | pages = 2910–2916 }}
{{cite journal | vauthors = Ejiri SI, Weissbach H, Brot N | year = 1979 | title = Reduction of methionine sulfoxide to methionine by Escherichia coli | journal = J. Bacteriol. | volume = 139 | pages = 161–4 | pmid = 37234 | issue = 1 | pmc = 216841 }}
{{cite journal | vauthors = Ejiri SI, Weissbach H, Brot N | year = 1980 | title = The purification of methionine sulfoxide reductase from Escherichia coli | journal = Anal. Biochem. | volume = 102 | pages = 393–8 | pmid = 6999943 | doi = 10.1016/0003-2697(80)90173-6 | issue = 2 }}
{{cite journal | vauthors = Weissbach H, Resnick L, Brot N | year = 2005 | title = Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage | journal = Biochim. Biophys. Acta | volume = 1703 | pages = 203–12 | pmid = 15680228 | issue = 2 | doi = 10.1016/j.bbapap.2004.10.004 }}

2 : EC 1.8.4|Enzymes of unknown structure

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