| 词条 | Lophophine |
| 释义 |
| verifiedrevid = 415683864 | IUPAC_name = 2-(7-methoxy-1,3-benzodioxol-5-yl)ethanamine | image = Lophophine.png | tradename = | pregnancy_category = ? | legal_status = Uncontrolled (but may be covered under the Federal Analogue Act in the United States and under similar bills in other countries due to its similarity to mescaline and MMDA) | routes_of_administration = Oral | bioavailability = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 23693-38-1 | ATC_prefix = none | ATC_suffix = | PubChem = 90239 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 81465 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 159620 | C=10 | H=13 | N=1 | O=3 | molecular_weight = 195.22 g/mol | smiles = O1c2cc(cc(OC)c2OC1)CCN | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C10H13NO3/c1-12-8-4-7(2-3-11)5-9-10(8)14-6-13-9/h4-5H,2-3,6,11H2,1H3 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = ORXQUAPZHKCCAX-UHFFFAOYSA-N }} Lophophine (MMDPEA, 3-methoxy-4,5-methylenedioxyphenethylamine) is a putative psychedelic and entactogen drug of the methylenedioxyphenethylamine class. It is the α-demethylated homologue of MMDA, and is also closely related to mescaline. Alexander Shulgin originally suggested that lophophine may be a natural constituent of peyote (Lophophora williamsii) due to it being the only logical chemical intermediate for the biosynthesis of several tetrahydroisoquinolines known to be present in this cactus species.[1] Subsequently, lophophine was indeed shown to be a minor component of both peyote and San Pedro cactus.[2]Shulgin reports that lophophine is active in the dosage range of 150–250 mg. He states that at these doses, lophophine has some similarity to mescaline in action, in producing a peaceful elevation of mood, euphoria, and mild enhancement of visual perception, but without the generation of closed-eye mental imagery. Shulgin also notes that (in contrast to mescaline), lophophine causes no nausea.[1] At dosages above 300 mg, visual distortions that resemble those of standard doses of mescaline are said to begin to appear.{{citation needed|date=September 2012}} See also
References1. ^1 A. Shulgin and A. Shulgin (1991). Pihkal, pp.701-702, Transform Press, Berkeley. 2. ^{{cite journal |vauthors=Bruhn JG, El-Seedi HR, Stephanson N, Beck O, Shulgin AT | title = Ecstasy analogues found in cacti | journal = Journal of Psychoactive Drugs | volume = 40 | issue = 2 | pages = 219–22 |date=June 2008 | pmid = 18720674 | doi = 10.1080/02791072.2008.10400635| url = | citeseerx = 10.1.1.689.4014 }} External links
6 : Benzodioxoles|Phenethylamines|Phenol ethers|Psychedelic phenethylamines|Serotonin receptor agonists|Phenethylamine alkaloids |
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