| 词条 | Low-intensity pulsed ultrasound |
| 释义 |
| name = Low-intensity pulsed ultrasound | synonym = | image = | caption = | alt = | pronounce = | specialty = | synonyms = | ICD10 = | ICD9 = | ICD9unlinked = | CPT = | MeshID = | LOINC = | other_codes = | MedlinePlus = | eMedicine = }}Low-intensity pulsed ultrasound (LIPUS) is a medical technology, generally using 1.5 MHz frequency pulses, with a pulse width of 200 μs, repeated at 1 kHz, at a spatial average and temporal average intensity of 30 mW/cm2.[1] As of 2009 research for the use of LIPUS to treat soft tissue injuries were in the early stages.[1] As of 2012 it was being studied for dental problems.[2] Medical usesStarting around the 1950s this technology was being used as a form of physical therapy for ailments such as tendinitis.[3] Low intensity pulsed ultrasound has been proposed as a therapy to support bone healing after fractures, osteotomies, or delayed healing. A 2017 review, however, found no trustworthy evidence for the use of low intensity pulsed ultrasound for bone healing.[4] An associated guideline issued a strong recommendation against its use in bone healing.[5] Evidence as of 2014 was insufficient to justify its use to prevent non healing of bone fractures.[6] Tentative evidence supports better healing with the use of the system in long bones that have not healed after three months.[7] Some reviews suggested inconclusive evidence of benefit.[8] One industry supported meta-analysis suggested it as a potential alternative to surgery for established nonunions.[9] Most studies suggesting benefit were funded by manufacturers of ultrasound devices.[4] In 2018, a study published in the journal Brain Stimulation, reported that experiments on mice showed that whole-brain LIPUS therapy markedly improved cognitive dysfunctions without serious side effects by enhancing specific cells related to dementia's pathology. Clinical trials are underway.[10] References1. ^1 {{cite journal|last1=Khanna|first1=A|last2=Nelmes|first2=RT|last3=Gougoulias|first3=N|last4=Maffulli|first4=N|last5=Gray|first5=J|title=The effects of LIPUS on soft-tissue healing: a review of literature.|journal=British Medical Bulletin|date=2009|volume=89|pages=169–82|pmid=19011263|doi=10.1093/bmb/ldn040}} 2. ^{{Cite journal | doi = 10.2174/1874210601206010220| title = Current Status of Low Intensity Pulsed Ultrasound for Dental Purposes| journal = The Open Dentistry Journal| volume = 6| pages = 220–5| year = 2012| last1 = Rego | first1 = E. B.| pmid=23341848| pmc=3547311}} 3. ^{{Cite journal|last=Miller|first=Douglas|last2=Smith|first2=Nadine|last3=Bailey|first3=Michael|last4=Czarnota|first4=Gregory|last5=Hynynen|first5=Kullervo|last6=Makin|first6=Inder|date=April 2012|title=Overview of Therapeutic Ultrasound Applications and Safety Considerations|journal=Journal of Ultrasound in Medicine|volume=31|issue=4|pages=623–634|doi=10.7863/jum.2012.31.4.623|issn=0278-4297|pmc=3810427|pmid=22441920}} 4. ^1 {{cite journal|last1=Schandelmaier|first1=Stefan|last2=Kaushal|first2=Alka|last3=Lytvyn|first3=Lyubov|last4=Heels-Ansdell|first4=Diane|last5=Siemieniuk|first5=Reed A. C.|last6=Agoritsas|first6=Thomas|last7=Guyatt|first7=Gordon H.|last8=Vandvik|first8=Per O.|last9=Couban|first9=Rachel|last10=Mollon|first10=Brent|last11=Busse|first11=Jason W.|title=Low intensity pulsed ultrasound for bone healing: systematic review of randomized controlled trials|journal=BMJ|date=22 February 2017|volume=356|pages=j656|doi=10.1136/bmj.j656|pmid=28348110|pmc=5484179|url=http://www.bmj.com/content/356/bmj.j656|issn=1756-1833|doi-broken-date=2019-03-13}} 5. ^{{cite journal|last1=Poolman|first1=RW|last2=Agoritsas|first2=T|last3=Siemieniuk|first3=RA|last4=Harris|first4=IA|last5=Schipper|first5=IB|last6=Mollon|first6=B|last7=Smith|first7=M|last8=Albin|first8=A|last9=Nador|first9=S|last10=Sasges|first10=W|last11=Schandelmaier|first11=S|last12=Lytvyn|first12=L|last13=Kuijpers|first13=T|last14=van Beers|first14=LW|last15=Verhofstad|first15=MH|last16=Vandvik|first16=PO|title=Low intensity pulsed ultrasound (LIPUS) for bone healing: a clinical practice guideline.|journal=BMJ (Clinical Research Ed.)|date=21 February 2017|volume=356|pages=j576|pmid=28228381|doi=10.1136/bmj.j576}} 6. ^{{cite journal|last1=Griffin|first1=XL|last2=Parsons|first2=N|last3=Costa|first3=ML|last4=Metcalfe|first4=D|title=Ultrasound and shockwave therapy for acute fractures in adults.|journal=The Cochrane Database of Systematic Reviews|date=23 June 2014|issue=6|pages=CD008579|pmid=24956457|doi=10.1002/14651858.CD008579.pub3}} 7. ^{{cite journal|last1=Higgins|first1=A|last2=Glover|first2=M|last3=Yang|first3=Y|last4=Bayliss|first4=S|last5=Meads|first5=C|last6=Lord|first6=J|title=EXOGEN ultrasound bone healing system for long bone fractures with non-union or delayed healing: a NICE medical technology guidance.|journal=Applied Health Economics and Health Policy|date=October 2014|volume=12|issue=5|pages=477–84|pmid=25060830|doi=10.1007/s40258-014-0117-6|pmc=4175405}} 8. ^{{citejournal|last1=Lou|first1=S.|last2=Lv|first2=H.|last3=Li|first3=Z.|last4=Zhang|first4=L.|last5=Tang|first5=P|title= The effects of low-intensity pulsed ultrasound on fresh fracture: A meta-analysis|journal=Medecine|date=1 September 2017|issue=39|pages=e8181|pmid=28953676 }} 9. ^{{citejournal |last1=Leighton|first1= R. |last2= Watson |first2=J.T |last3= Giannoudis|first3=P.|last4=Papakostidis|first4=C.|last5=Harrison|first5=A. |last6=Steen|first6=R.G. |title= Healing of fracture nonunions treated with low-intensity pulsed ultrasound (LIPUS): A systematic review and meta-analysis|journal=Injury|date=May 2017|issue=7|pages=1339–1347|pmid= 28532896}} 10. ^{{Cite news|url=https://www.news-medical.net/news/20180720/Ultrasound-waves-applied-to-the-brain-improve-cognitive-dysfunction-in-mice-simulating-dementia-Alzheimers.aspx|title=Whole-brain LIPUS therapy improves cognitive dysfunction in mice simulating dementia, Alzheimer's|last=|first=|date=2018-07-20|work=News-Medical.net|access-date=2018-07-20|language=en|df=mdy-all}} 2 : Dentistry|Medical ultrasonography |
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