“L-threonine 3-dehydrogenase”的意思、由来-开放百科全书

词条

L-threonine 3-dehydrogenase

释义

Structural studies
References

{{enzyme
| Name = L-threonine 3-dehydrogenase
| EC_number = 1.1.1.103
| CAS_number = 9067-99-6
| IUBMB_EC_number = 1/1/1/103
| GO_code = 0008743
| image =
| width =
| caption =
}}

In enzymology, a L-threonine 3-dehydrogenase ({{EC number|1.1.1.103}}) is an enzyme that catalyzes the chemical reaction

L-threonine + NAD⁺ L-2-amino-3-oxobutanoate + NADH + H⁺

Thus, the two substrates of this enzyme are L-threonine and NAD⁺, whereas its 3 products are L-2-amino-3-oxobutanoate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is L-threonine:NAD⁺ oxidoreductase. Other names in common use include L-threonine dehydrogenase, threonine 3-dehydrogenase, and threonine dehydrogenase. This enzyme participates in glycine, serine and threonine metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|2D8A}}, {{PDB link|2DFV}}, and {{PDB link|2DQ4}}.

References

{{cite journal | vauthors = Green ML, Elliott WH | date = 1964 | title = The enzymic formation of aminoacetone from threonine and its further metabolism | journal = Biochem. J. | volume = 92 | pages = 537–49 | pmid = 4284408 | issue = 3 | pmc = 1206098 }}
{{cite journal | vauthors = Hartshorne D, Greenberg DM | date = 1964 | title = Studies on liver threonine dehydrogenase | journal = Arch. Biochem. Biophys. | volume = 105 | pages = 173–8 | pmid = 14165492 | doi = 10.1016/0003-9861(64)90250-4 }}

3 : EC 1.1.1|NADH-dependent enzymes|Enzymes of known structure

随便看

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。