David Houston may refer to:

• David F. Houston (1866–1940), American politician, Secretary of Agriculture and the Treasury under President Wilson
• David Houston (singer) (1935–1993), American country music singer
• David Houston (zoologist), British zoologist
• David Houston, British Army officer and Lord Lieutenant of Sutherland, 1992–2005
• David Houston (footballer) (born 1948), Scottish footballer and manager

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• M-188 (Michigan)
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• M-189
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• M18A1 Claymore mine
• M18A1 claymore mine
• M18 (disambiguation)