| 词条 | Magnesium stearate |
| 释义 |
| Watchedfields = changed | verifiedrevid = 443932332 | ImageFile=magnesium stearate.png | ImageSize=250px | Name = Magnesium stearate | IUPACName = Magnesium octadecanoate |Section1={{Chembox Identifiers | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} {CH} | ChemSpiderID = 10704 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 70097M6I30 | InChI = 1/2C18H36O2.Mg/c2*1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2*2-17H2,1H3,(H,19,20);/q;;+2/p-2 | InChIKey = HQKMJHAJHXVSDF-NUQVWONBAM | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/2C18H36O2.Mg/c2*1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2*2-17H2,1H3,(H,19,20);/q;;+2/p-2 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = HQKMJHAJHXVSDF-UHFFFAOYSA-L | CASNo_Ref = {{cascite|correct|CAS}} | CASNo = 557-04-0 | PubChem = 11177 | ChEBI_Ref = {{ebicite|correct|EBI}} | ChEBI = 9254 | SMILES = [Mg+2].[O-]C(=O)CCCCCCCCCCCCCCCCC.[O-]C(=O)CCCCCCCCCCCCCCCCC }} |Section2={{Chembox Properties | Formula = {{chem|Mg({{chem|C|18|H|35|O|2}})|2}} | MolarMass = 591.27 g/mol | Appearance = light white powder | Odor = slight | MeltingPtC = 88.5 | BoilingPt = | Solubility = 0.003 g/100 mL (15 °C) 0.004 g/100 mL (25 °C) 0.008 g/100 mL (50 °C) | SolubleOther = negligible in ether and alcohol slightly soluble in benzene | Density = 1.026 g/cm3 }} |Section7={{Chembox Hazards | ExternalSDS = External MSDS | FlashPtC = 250 | LD50 = > 1000 mg/kg (oral, rat) | NFPA-H = 1 | NFPA-F = 1 | NFPA-R = 0 }} }}Magnesium stearate is the chemical compound with the formula {{chem|Mg({{chem|C|18|H|35|O|2}})|2}}. It is a soap, consisting of salt containing two equivalents of stearate (the anion of stearic acid) and one magnesium cation (Mg2+). Magnesium stearate is a white, water-insoluble powder. Its applications exploit its softness, insolubility in many solvents, and low toxicity. It is used as a release agent and as a component or lubricant in the production of pharmaceuticals and cosmetics.[1] ManufacturingMagnesium stearate is produced by the reaction of sodium stearate with magnesium salts or by treating magnesium oxide with stearic acid.[1] Some nutritional supplements specify that the sodium stearate used in manufacturing magnesium stearate is produced from vegetable-derived stearic acid.[2] UsesMagnesium stearate is often used as an anti-adherent[3] in the manufacture of medical tablets, capsules and powders.[4] In this regard, the substance is also useful because it has lubricating properties, preventing ingredients from sticking to manufacturing equipment during the compression of chemical powders into solid tablets; magnesium stearate is the most commonly used lubricant for tablets.[5] However, it might cause lower wettability and slower disintegration of the tablets and slower and even lower dissolution of the drug.[6] Magnesium stearate can also be used efficiently in dry coating processes.[7][8][9] In the creation of pressed candies, magnesium stearate acts as a release agent and it is used to bind sugar in hard candies such as mints.[10] Magnesium stearate is a common ingredient in baby formulas.[11] OccurrenceMagnesium stearate is a major component of bathtub rings. When produced by soap and hard water, magnesium stearate and calcium stearate both form a white solid insoluble in water, and are collectively known as soap scum. SafetyMagnesium stearate is generally considered safe for human consumption at levels below 2500 mg/kg per day[12] and is classified in the United States as generally recognized as safe (GRAS). In 1979, the FDA's Subcommittee on GRAS Substances (SCOGS) reported, "There is no evidence in the available information on ... magnesium stearate ... that demonstrates, or suggests reasonable grounds to suspect, a hazard to the public when they are used at levels that are now current and in the manner now practiced, or which might reasonably be expected in the future."[13] References1. ^1 Angelo Nora, Alfred Szczepanek, Gunther Koenen, "Metallic Soaps" in Ullmann's Encyclopedia of Industrial Chemistry 2005 Wiley-VCH, Weinheim. {{DOI|10.1002/14356007.a16_361}} 2. ^{{cite web |url= http://dsld.nlm.nih.gov/dsld/rptQSearch.jsp?item=Magnesium+Stearate&db=adsld |title= Quick search results of the DSLD |website= Dietary Supplement Label Database |publisher= National Institutes of Health |access-date= 27 December 2015}} 3. ^{{cite journal |doi= 10.1021/cen-v086n001.p025 |year= 2008 |volume= 86 |issue= 1 |pages= 25 |title= What's That Stuff? Excipients: Inactive ingredients in medicines serve multiple functions in drug delivery |first= Steve |last= Ritter |journal= Chemical & Engineering News |url= http://pubs.acs.org/cen/whatstuff/86/8601sci3.html}} 4. ^{{Cite book |isbn= 9780824728243 |page= 2274 |last1= Sworbrick |first1= James |first2= James C. |last2= Boylan |title= Encyclopedia of pharmaceutical technology |date= 1990}} 5. ^{{Cite book |isbn= 9780824782108 |page= 10 |last1= Weiner |first1= Myra L. |first2= Lois A. |last2= Kotkoskie |title= Excipient Toxicity and Safety |date= 1999}} 6. ^{{cite journal|last1=Demuth|display-authors=etal|title=Investigation of Deteriorated Dissolution of Amorphous Itraconazole: Description of Incompatibility with Magnesium Stearate and Possible Solutions|journal=Molecular Pharmaceutics|date=2017|volume=14|issue=11|pages=3927–3934|doi=10.1021/acs.molpharmaceut.7b00629|pmid=28972782|url=https://www.researchgate.net/publication/320207928}} 7. ^{{cite journal |author = Ouabbas Y, Dodds J., Galet L., Chamayou A. , Baron M. | title = Particle-particle coating in a cyclomix impact mixer | journal = Powder Technol. | volume = 189 | issue = 2 | date = 2009 |pages = 245–252 | doi = 10.1016/j.powtec.2008.04.031}} 8. ^{{cite journal |author = Thomas G., Ouabbas Y., Grosseau P., Baron M., Chamayou A., Galet L.| title = Modeling the main interaction forces between powder particles. Application to silica gel-magnesium stearate mixtures | journal = Applied Surface Science | volume = 255 | issue = 17 | date = 2009 |pages = 7500–7507 | doi = 10.1016/j.apsusc.2009.03.099| citeseerx = 10.1.1.591.1899 }} 9. ^{{cite journal |author = Sato A., Serris E., Grosseau P., Thomas G., Galet L., Chamayou A. , Baron M.| title = Experiment and simulation of dry particle coating | journal = Chem. Eng. Science | volume = 86 | date = 2013 |pages = 164–172 | doi = 10.1016/j.ces.2012.07.037| url = https://hal.archives-ouvertes.fr/hal-00616515/file/AS-Lausanne-Orig.pdf }} 10. ^https://www.ctahr.hawaii.edu/oc/freepubs/pdf/FST-9.pdf 11. ^{{cite book | author = Erich Lück and Gert-Wolfhard von Rymon Lipinski | title = Ullmann's Encyclopedia of Industrial Chemistry | date = 2002 | publisher = Wiley-VCH | location = Weinheim| doi = 10.1002/14356007.a11_561| isbn = 978-3527306732 | chapter = Foods, 3. Food Additives }} 12. ^{{Cite journal |doi= 10.1016/0300-483X(80)90026-8 |first1= D. |last1= Søndergaarda |first2= O. |last2= Meyera |first3= G. |last3= Würtzena |title= Magnesium stearate given peroprally to rats. A short term study |journal= Toxicology |volume= 17 |issue= 1 |year= 1980 |pages= 51–55 |pmid= 7434368|url= http://orbit.dtu.dk/en/publications/magnesium-stearate-given-perorally-to-rats--a-shortterm-study(b93fa356-078a-4f8b-9795-3590746396c9).html }} 13. ^FDA's SCOGS Database; Report No. 60; ID Code: 557-04-0; Year: 1979 3 : Excipients|Magnesium compounds|Stearates |
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