“Malate dehydrogenase (oxaloacetate-decarboxylating)”的意思、由来-开放百科全书

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Malate dehydrogenase (oxaloacetate-decarboxylating)

释义

Structural studies
See also
References

{{enzyme
| Name = malate dehydrogenase (oxaloacetate-decarboxylating)
| EC_number = 1.1.1.38
| CAS_number = 9080-52-8
| IUBMB_EC_number = 1/1/1/38
| GO_code = 0016619
| image = 1efk.jpg
| width =
| caption = malic enzyme tetramer, Human
}}

In enzymology, a malate dehydrogenase (oxaloacetate-decarboxylating) ({{EC number|1.1.1.38}}) is an enzyme that catalyzes the chemical reaction

(S)-malate + NAD⁺ pyruvate + CO₂ + NADH

Thus, the two substrates of this enzyme are (S)-malate and NAD⁺, whereas its 3 products are pyruvate, CO₂, and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (S)-malate:NAD⁺ oxidoreductase (oxaloacetate-decarboxylating). Other names in common use include malic enzyme, pyruvic-malic carboxylase, NAD⁺-specific malic enzyme, NAD⁺-malic enzyme, and NAD⁺-linked malic enzyme. This enzyme participates in pyruvate metabolism.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1DO8}}, {{PDB link|1EFK}}, {{PDB link|1EFL}}, {{PDB link|1GZ3}}, {{PDB link|1LLQ}}, {{PDB link|1O0S}}, {{PDB link|1PJ2}}, {{PDB link|1PJ3}}, {{PDB link|1PJ4}}, {{PDB link|1PJL}}, {{PDB link|1QR6}}, {{PDB link|1WW8}}, and {{PDB link|2DVM}}.

References

{{cite journal | vauthors = Kaufman S, Korkes S, del Campillo A | date = 1951 | title = Biosynthesis of dicarboxylic acids by carbon dioxide fixation. V Further studies of the "malic" enzyme of Lactobacillus arabinosus | journal = J. Biol. Chem. | volume = 192 | pages = 301–312 }}

3 : EC 1.1.1|NADH-dependent enzymes|Enzymes of known structure

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Structural studies

See also

References