“Malate dehydrogenase (quinone)”的意思、由来-开放百科全书

词条

Malate dehydrogenase (quinone)

释义

References

{{enzyme
| Name = malate dehydrogenase (quinone)
| EC_number = 1.1.5.4
| CAS_number = 71822-24-7
| IUBMB_EC_number = 1/1/5/4
| GO_code = 0052589
| image =
| width =
| caption =
}}

In enzymology, a malate dehydrogenase (quinone) ({{EC number|1.1.5.4}}), formerly malate dehydrogenase (acceptor) (EC 1.1.99.16), is an enzyme that catalyzes the chemical reaction

(S)-malate + a quinone oxaloacetate + reduced quinone

Thus, the two substrates of this enzyme are (S)-malate and a quinone, whereas its two products are oxaloacetate and reduced quinone.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with a quinone as acceptor. The systematic name of this enzyme class is (S)-malate:quinone oxidoreductase. Other names in common use include FAD-dependent malate-vitamin K reductase, malate-vitamin K reductase, and (S)-malate:(quinone) oxidoreductase. This enzyme participates in pyruvate metabolism. It employs one cofactor, FAD.

References

{{cite journal |author1 = Imai D |author2 =Brodie AF | date = 1973 | title = A phospholipid-requiring enzyme, malate-vitamin K reductase | journal = J. Biol. Chem. | volume = 248 | pages = 7487–7494 }}
{{cite journal | author = Imai T | date = 1978 | title = FAD-dependent malate dehydrogenase, a phospholipid-requiring enzyme from Mycobacterium sp. strain Takeo. Purification and some properties | journal = Biochim. Biophys. Acta | volume = 523 | pages = 37–46 | pmid = 629992 | issue = 1 | doi=10.1016/0005-2744(78)90006-2}}
{{cite journal | vauthors = Prasada Reddy TL, Suryanarayana Murthy P, Venkitasubramanian TA | date = 1975 | title = Variations in the pathways of malate oxidation and phosphorylation in different species of Mycobacteria | journal = Biochim. Biophys. Acta | volume = 376 | pages = 210–8 | pmid = 234747 | issue = 2 | doi=10.1016/0005-2728(75)90012-2}}

3 : EC 1.1.5|Flavin enzymes|Enzymes of unknown structure

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