| 词条 | Malignant histiocytosis |
| 释义 |
| name = Malignant histiocytosis | image = | caption = | | pronounce = | field = | synonyms = | symptoms = | complications = | onset = | duration = | types = | causes = | risks = | diagnosis = | differential = | prevention = | treatment = | medication = | prognosis = | frequency = | deaths = }}Malignant histiocytosis (also known as "Histiocytic medullary reticulosis"[1]{{rp|744}}) is a rare hereditary disease found in the Bernese Mountain Dog and humans, characterized by histiocytic infiltration of the lungs and lymph nodes. The liver, spleen, and central nervous system can also be affected. Histiocytes are a component of the immune system that proliferate abnormally in this disease. In addition to its importance in veterinary medicine, the condition is also important in human pathology.[2] Histiocytic disordersA histiocyte is a differentiated tissue cell that has its origin in the bone marrow. The source for histiocytes is the monocyte/macrophage line. Monocytes (found in the blood) and macrophages (found in tissue) are responsible for phagocytosis (ingestion) of foreign material in the body. Langerhans cells are dendritic cells found in the skin and function by internalizing antigens (foreign particles) and presenting them to T cells. They arise from monocytes.[3] Histiocytic disorders refer to diseases that are caused by abnormal behavior of these cells. They include the following:
Breed dispositionUp to 25 percent of Bernese Mountain Dogs may develop malignant histiocytosis in their lifetime.[4] Other breeds with a possible genetic tendency toward malignant histiocytosis include Rottweilers, Flat-Coated Retrievers, and Golden Retrievers.[5] Signs and symptomsThe disease in the lungs is characterized by enlargement of the tracheobronchial lymph nodes and infiltration of the lungs, sometimes leading to lung lobe consolidation and pleural effusion.[6] Signs and symptoms include cough, loss of appetite, weight loss, anemia, and difficulty breathing.[7] Seizures and rear limb weakness can be seen. Invasion of the bone marrow can cause pancytopenia.[8] Diagnosis requires a biopsy. TreatmentTreatment with chemotherapy has been used with some success, particularly using lomustine, prednisone, doxorubicin, and cyclophosphamide.[9] Because of the rapid progression of this aggressive disease, the prognosis is very poor.[10] Other histiocytic diseases in Bernese Mountain DogsA similar disease is diffuse histiocytic sarcoma, a term used to designate a localized histiocytic sarcoma that has spread throughout the body.[9] Another disease of histiocytic origin that affects Bernese Mountain Dogs is systemic histiocytosis. This condition generally begins as lesions on the eyelids, nasal mucosa, and skin, especially the scrotum. It progresses to a more generalized disease affecting the lymph nodes, bone marrow and spleen.[11] Other signs and symptoms include weight loss and loss of appetite.[9] It also has a very poor prognosis. See also
References1. ^{{cite book |author1=James, William D. |author2=Berger, Timothy G. |title=Andrews' Diseases of the Skin: clinical Dermatology |publisher=Saunders Elsevier |location= |year=2006 |pages= |isbn=0-7216-2921-0 |oclc= |doi= |accessdate=|display-authors=etal}} 2. ^Malignant histiocytoses. DermNet NZ 3. ^{{cite journal |vauthors=Ginhoux F, Tacke F, Angeli V, Bogunovic M, Loubeau M, Dai XM, Stanley ER, Randolph GJ, Merad M |title=Langerhans cells arise from monocytes in vivo |journal=Nat. Immunol. |volume=7 |issue=3 |pages=265–73 |year=2006 |pmid=16444257 |doi=10.1038/ni1307|pmc=4727824 }} 4. ^{{cite web|author=Parker, A.G.|author2=Rutteman, G.R.|author3=Cadieu, E.|year=2006|title=Malignant Histiocytosis in the Bernese Mountain Dog: Design and Execution of a Case-Control Study|work=Genes, Dogs and Cancer: Fourth Annual Canine Cancer Conference| url=http://www.ivis.org/proceedings/keystone/2006/sessionB/parker/chapter.asp?la=1|accessdate=2007-01-28|display-authors=etal}} 5. ^{{cite book|author1=Ettinger, Stephen J. |author2=Feldman, Edward C. |title=Textbook of Veterinary Internal Medicine|edition=4th|publisher=W.B. Saunders Company|year=1995|isbn=0-7216-6795-3}} 6. ^{{cite web|author=Kessler, Martin|year=2006|title=Radiographic diagnosis of primary and metastatic lung tumors|work=Proceedings of the North American Veterinary Conference|url=http://www.ivis.org/proceedings/navc/2006/SAE/275.pdf?LA=1|accessdate=2007-01-28|deadurl=yes|archiveurl=https://web.archive.org/web/20070929105002/http://www.ivis.org/proceedings/navc/2006/SAE/275.pdf?LA=1|archivedate=2007-09-29|df=}} 7. ^{{cite web | last = Affolter | first = Verena K. | title = Histiocytic Proliferative Diseases in Dogs and Cats | work = Proceedings of the 29th World Congress of the World Small Animal Veterinary Association | year = 2004 | url = http://www.vin.com/proceedings/Proceedings.plx?CID=WSAVA2004&PID=8600&O=Generic | accessdate = 2007-01-28 }} 8. ^{{cite journal | last = Kearns | first = Shawn Ann |author2=Ewing, Patty | title = Causes of canine and feline pancytopenia | journal = Compendium on Continuing Education for the Practicing Veterinarian | volume = 28 | issue = 2 | pages = 122–133 | publisher = Veterinary Learning Systems | date = Feb 2006 }} 9. ^1 2 {{cite journal | last = Cronin | first = Kim | title = Deciphering the histiocytic code | journal = DVM | pages = 1S–8S | publisher = Advanstar Communications | date = Dec 2006 }} 10. ^{{cite journal |vauthors=Affolter V, Moore P |title=Localized and disseminated histiocytic sarcoma of dendritic cell origin in dogs |journal=Vet Pathol |volume=39 |issue=1 |pages=74–83 |year=2002 |pmid=12102221 |doi=10.1354/vp.39-1-74}} 11. ^{{cite web | title = Tumors with Histiocytic Differentiation | work = The Merck Veterinary Manual | year = 2006 | url = http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm/bc/72232.htm | accessdate = 2007-01-28 }} External links{{Medical resources| DiseasesDB = | ICD10 = {{ICD10|C|96|1|c|81}} | ICD9 = {{ICD9|202.3}} | ICDO = {{ICDO|9750|3}} | OMIM = | MedlinePlus = | eMedicineSubj = | eMedicineTopic = | MeshID = D015620 }}
3 : Dog diseases|Lymphoid-related cutaneous conditions|Histiocytosis |
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