| 词条 | Mallory body |
| 释义 |
In histopathology, a Mallory body, Mallory-Denk body, and Mallory's hyaline, is an inclusion found in the cytoplasm of liver cells.[1] Mallory bodies are damaged intermediate filaments within the hepatocytes. Associated conditionsMallory bodies are classically found in the livers of people suffering from alcoholic liver disease and were once thought to be specific for that.[2] They are most common in alcoholic hepatitis (prevalence of 65%) and alcoholic cirrhosis (prevalence of 51%).[3] They are a recognized feature of Wilson's disease (25%), primary biliary cirrhosis (24%), non-alcoholic cirrhosis (24%), hepatocellular carcinoma (23%) and morbid obesity (8%), among other conditions.[3] However, it has also been reported in certain other unrelated conditions.[4] AppearanceMallory bodies are highly eosinophilic and thus appear pink on H&E stain. The bodies themselves are made up of intermediate cytokeratin 8/18 filament proteins that have been ubiquinated, or bound by other proteins such as heat shock proteins, or p62. EponymIt is named for the American pathologist Frank Burr Mallory, who first described the structures in 1911.[3] They were renamed as Mallory-Denk bodies in 2007 to honor the contribution of Austrian pathologist Helmut Denk for the molecular analysis of the pathogenesis of MDBs. See also
Additional imagesReferences1. ^{{cite web |url=http://library.med.utah.edu/WebPath/CINJHTML/CINJ033.html |title=Cell Injury |work= |accessdate=}} {{Eponymous medical signs for digestive system and general abdominal signs}}2. ^{{cite journal|last1=Denk|first1=H|last2=Franke|first2=WW|last3=Eckerstorfer|first3=R|last4=Schmid|first4=E|last5=Kerjaschki|first5=D|title=Formation and involution of Mallory bodies ("alcoholic hyalin") in murine and human liver revealed by immunofluorescence microscopy with antibodies to prekeratin.|journal=Proceedings of the National Academy of Sciences of the United States of America|date=August 1979|volume=76|issue=8|pages=4112–6|pmid=386356|url=http://www.pnas.org/content/76/8/4112.full.pdf|pmc=383988|doi=10.1073/pnas.76.8.4112}} 3. ^1 2 {{Cite journal | last1 = Jensen | first1 = K | last2 = Gluud | first2 = C | title = The Mallory body: morphological, clinical and experimental studies (Part 1 of a literature survey). | journal = Hepatology | volume = 20 | issue = 4 Pt 1 | pages = 1061–77 |date=Oct 1994 | doi = 10.1002/hep.1840200440| pmid = 7927209 }} 4. ^{{cite journal|last1=Michel|first1=RP|last2=Limacher|first2=JJ|last3=Kimoff|first3=RJ|title=Mallory bodies in scar adenocarcinoma of the lung.|journal=Human Pathology|date=January 1982|volume=13|issue=1|pages=81–5|doi=10.1016/S0046-8177(82)80143-3|pmid=6176520}} 1 : Histopathology |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。