“Mannitol 2-dehydrogenase (NADP+)”的意思、由来-开放百科全书

词条

Mannitol 2-dehydrogenase (NADP+)

释义

Structural studies
References

{{DISPLAYTITLE:Mannitol 2-dehydrogenase (NADP⁺)}}{{enzyme
| Name = mannitol 2-dehydrogenase (NADP⁺)
| EC_number = 1.1.1.138
| CAS_number = 37250-68-3
| IUBMB_EC_number = 1/1/1/138
| GO_code = 0050085
| image =
| width =
| caption =
}}

In enzymology, a mannitol 2-dehydrogenase (NADP⁺) ({{EC number|1.1.1.138}}) is an enzyme that catalyzes the chemical reaction

D-mannitol + NADP⁺ D-fructose + NADPH + H⁺

Thus, the two substrates of this enzyme are D-mannitol and NADP⁺, whereas its 3 products are D-fructose, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is D-mannitol:NADP⁺ 2-oxidoreductase. This enzyme is also called mannitol 2-dehydrogenase (NADP⁺). This enzyme participates in fructose and mannose metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code {{PDB link|1H5Q}}.

References

{{cite journal |vauthors=Edmundowicz JM, Wriston JC | date = 1963 | title = Mannitol dehydrogenase from Agaricus campestris | journal = J. Biol. Chem. | volume = 238 | pages = 3539–41 | pmid = 14109183 }}
{{cite journal |author1 = Strobel GA |author2 =Kosuge T | date = 1965 | title = Polyol metabolism in Diplodia viticola Desm | journal = Arch. Biochem. Biophys. | volume = 109 | issue = 3 | pages = 622–626 | doi = 10.1016/0003-9861(65)90409-1 }}

3 : EC 1.1.1|NADPH-dependent enzymes|Enzymes of known structure

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