| 释义 |
- Function
- Interactions
- References
- Further reading
- External links
{{main|Mitogen-activated protein kinase kinase}}{{Infobox_gene}}Dual specificity mitogen-activated protein kinase kinase 2 is an enzyme that in humans is encoded by the MAP2K2 gene.[1] It is more commonly known as MEK2, but has many alternative names including CFC4, MKK2, MAPKK2 and PRKMK2. [2] Function The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK3/ERK1. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax.[3] InteractionsMAP2K2 has been shown to interact with MAPK3[4][5][6] and ARAF.[7] References1. ^{{cite journal | vauthors = Zheng CF, Guan KL | title = Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2 | journal = J Biol Chem | volume = 268 | issue = 15 | pages = 11435–9 |date=Jun 1993 | pmid = 8388392 | pmc = | doi = }}
2. ^{{Cite web|title = MAP2K2 mitogen-activated protein kinase kinase 2 [Homo sapiens (human)] - Gene - NCBI|url = https://www.ncbi.nlm.nih.gov/gene/5605|website = www.ncbi.nlm.nih.gov|accessdate = 2015-10-16}}
3. ^{{cite web | title = Entrez Gene: MAP2K2 mitogen-activated protein kinase kinase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5605| accessdate = }}
4. ^{{cite journal |last=Marti |first=A |authorlink= |author2=Luo Z |author3=Cunningham C |author4=Ohta Y |author5=Hartwig J |author6=Stossel T P |author7=Kyriakis J M |author8=Avruch J |date=Jan 1997 |title=Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells |journal=J. Biol. Chem. |volume=272 |issue=5 |pages=2620–8 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9006895 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.272.5.2620 }}
5. ^{{cite journal |last=Butch |first=E R |authorlink= |author2=Guan K L |date=Feb 1996 |title=Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2 |journal=J. Biol. Chem. |volume=271 |issue=8 |pages=4230–5 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 8626767 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.271.8.4230 }}
6. ^{{cite journal |last=Zheng |first=C F |authorlink= |author2=Guan K L |date=Nov 1993 |title=Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases |journal=J. Biol. Chem. |volume=268 |issue=32 |pages=23933–9 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 8226933 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
7. ^{{cite journal |last=Yin |first=Xiang L |authorlink= |author2=Chen She |author3=Yan Jun |author4=Hu Yun |author5=Gu Jian X |date=Feb 2002 |title=Identification of interaction between MEK2 and A-Raf-1 |journal=Biochim. Biophys. Acta |volume=1589 |issue=1 |pages=71–6 |publisher= |location = Netherlands| issn = 0006-3002| pmid = 11909642 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = | doi=10.1016/S0167-4889(01)00188-4}}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Joseph AM, Kumar M, Mitra D |title=Nef: "necessary and enforcing factor" in HIV infection. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 87–94 |year= 2005 |pmid= 15638726 |doi=10.2174/1570162052773013 }}
- {{cite journal | vauthors=Stove V, Verhasselt B |title=Modelling thymic HIV-1 Nef effects. |journal=Curr. HIV Res. |volume=4 |issue= 1 |pages= 57–64 |year= 2006 |pmid= 16454711 |doi=10.2174/157016206775197583 }}
- {{cite journal |vauthors=Charest DL, Mordret G, Harder KW, etal |title=Molecular cloning, expression, and characterization of the human mitogen-activated protein kinase p44erk1 |journal=Mol. Cell. Biol. |volume=13 |issue= 8 |pages= 4679–90 |year= 1993 |pmid= 7687743 |doi= | pmc=360094 }}
- {{cite journal |vauthors=Dérijard B, Raingeaud J, Barrett T, etal |title=Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms |journal=Science |volume=267 |issue= 5198 |pages= 682–5 |year= 1995 |pmid= 7839144 |doi=10.1126/science.7839144 |bibcode=1995Sci...267..682D }}
- {{cite journal |vauthors=Alessi DR, Saito Y, Campbell DG, etal |title=Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1 |journal=EMBO J. |volume=13 |issue= 7 |pages= 1610–9 |year= 1994 |pmid= 8157000 |doi= | pmc=394991 }}
- {{cite journal | vauthors =Zheng CF, Guan KL |title=Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases |journal=J. Biol. Chem. |volume=268 |issue= 32 |pages= 23933–9 |year= 1993 |pmid= 8226933 |doi= }}
- {{cite journal |vauthors=Wu J, Harrison JK, Dent P, etal |title=Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2 |journal=Mol. Cell. Biol. |volume=13 |issue= 8 |pages= 4539–48 |year= 1993 |pmid= 8393135 |doi= | pmc=360070 }}
- {{cite journal | vauthors=Moriguchi T, Gotoh Y, Nishida E |title=Activation of two isoforms of mitogen-activated protein kinase kinase in response to epidermal growth factor and nerve growth factor |journal=Eur. J. Biochem. |volume=234 |issue= 1 |pages= 32–8 |year= 1996 |pmid= 8529659 |doi=10.1111/j.1432-1033.1995.032_c.x }}
- {{cite journal | vauthors =Butch ER, Guan KL |title=Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2 |journal=J. Biol. Chem. |volume=271 |issue= 8 |pages= 4230–5 |year= 1996 |pmid= 8626767 |doi=10.1074/jbc.271.8.4230 }}
- {{cite journal | vauthors =Papin C, Denouel A, Calothy G, Eychène A |title=Identification of signalling proteins interacting with B-Raf in the yeast two-hybrid system |journal=Oncogene |volume=12 |issue= 10 |pages= 2213–21 |year= 1996 |pmid= 8668348 |doi= }}
- {{cite journal |vauthors=Downey GP, Butler JR, Brumell J, etal |title=Chemotactic peptide-induced activation of MEK-2, the predominant isoform in human neutrophils. Inhibition by wortmannin |journal=J. Biol. Chem. |volume=271 |issue= 35 |pages= 21005–1011 |year= 1996 |pmid= 8702863 |doi=10.1074/jbc.271.35.21005 }}
- {{cite journal | vauthors=Khoo S, Cobb MH |title=Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 11 |pages= 5599–604 |year= 1997 |pmid= 9159118 |doi=10.1073/pnas.94.11.5599 | pmc=20824 |bibcode=1997PNAS...94.5599K }}
- {{cite journal |vauthors=Li CJ, Ueda Y, Shi B |title=Tat protein induces self-perpetuating permissivity for productive HIV-1 infection |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 15 |pages= 8116–20 |year= 1997 |pmid= 9223324 |doi=10.1073/pnas.94.15.8116 | pmc=21566 |bibcode=1997PNAS...94.8116L }}
- {{cite journal | vauthors =Menegon A, Leoni C, Benfenati F, Valtorta F |title=Tat protein from HIV-1 activates MAP kinase in granular neurons and glial cells from rat cerebellum |journal=Biochem. Biophys. Res. Commun. |volume=238 |issue= 3 |pages= 800–5 |year= 1997 |pmid= 9325171 |doi= 10.1006/bbrc.1997.7393 }}
- {{cite journal |vauthors=Denouel-Galy A, Douville EM, Warne PH |title=Murine Ksr interacts with MEK and inhibits Ras-induced transformation |journal=Curr. Biol. |volume=8 |issue= 1 |pages= 46–55 |year= 1998 |pmid= 9427625 |doi=10.1016/S0960-9822(98)70019-3 }}
- {{cite journal |vauthors=Gibellini D, Bassini A, Pierpaoli S |title=Extracellular HIV-1 Tat protein induces the rapid Ser133 phosphorylation and activation of CREB transcription factor in both Jurkat lymphoblastoid T cells and primary peripheral blood mononuclear cells |journal=J. Immunol. |volume=160 |issue= 8 |pages= 3891–8 |year= 1998 |pmid= 9558095 |doi= }}
- {{cite journal |vauthors=Duesbery NS, Webb CP, Leppla SH |title=Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor |journal=Science |volume=280 |issue= 5364 |pages= 734–7 |year= 1998 |pmid= 9563949 |doi=10.1126/science.280.5364.734 |bibcode=1998Sci...280..734D }}
- {{cite journal |vauthors=Ganju RK, Munshi N, Nair BC |title=Human Immunodeficiency Virus Tat Modulates the Flk-1/KDR Receptor, Mitogen-Activated Protein Kinases, and Components of Focal Adhesion in Kaposi's Sarcoma Cells |journal=J. Virol. |volume=72 |issue= 7 |pages= 6131–7 |year= 1998 |pmid= 9621077 |doi= | pmc=110419 }}
- {{cite journal |vauthors=Tanimura S, Chatani Y, Hoshino R |title=Activation of the 41/43 kDa mitogen-activated protein kinase signaling pathway is required for hepatocyte growth factor-induced cell scattering |journal=Oncogene |volume=17 |issue= 1 |pages= 57–65 |year= 1998 |pmid= 9671314 |doi= 10.1038/sj.onc.1201905 }}
{{refend}}External links- [https://www.ncbi.nlm.nih.gov/books/NBK1186/ GeneReviews/NCBI/NIH/UW entry on Cardiofaciocutaneous Syndrome]
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