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词条 MAP3K7
释义

  1. Function

  2. Interactions

  3. References

  4. Further reading

{{main|MAP kinase kinase kinase}}{{Infobox_gene}}Mitogen-activated protein kinase kinase kinase 7 (MAP3K7), also known as TAK1, is an enzyme that in humans is encoded by the MAP3K7 gene.[1]

Function

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. TAK1 is a central regulator of cell death and is activated through a diverse set of intra- and extracellular stimuli. TAK1 regulates cell survival not solely through NF-κB but also through NF-κB-independent pathways such as oxidative stress and receptor-interacting protein kinase 1 (RIPK1) kinase activity-dependent pathway.[2] In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.[3]

Interactions

MAP3K7 has been shown to interact with:

{{div col|colwidth=20em}}
  • ASK1,[4]
  • CHUK,[5][5]
  • MAP2K6,[5][8][9][6]
  • MAP3K7IP1,[7][8][13][9]
  • MAP3K7IP2,[10][11][12]
  • MAP3K7IP3,[13][10]
  • Mothers against decapentaplegic homolog 6,[14][15]
  • PPM1B,[16] and
  • TRAF6.[4][7][13][11][12][17][18]
{{Div col end}}

References

1. ^{{cite journal | vauthors = Kondo M, Osada H, Uchida K, Yanagisawa K, Masuda A, Takagi K, Takahashi T, Takahashi T | title = Molecular cloning of human TAK1 and its mutational analysis in human lung cancer | journal = Int J Cancer | volume = 75 | issue = 4 | pages = 559–63 | date = February 1998 | pmid = 9466656 | pmc = | doi = 10.1002/(SICI)1097-0215(19980209)75:4<559::AID-IJC11>3.0.CO;2-4 }}
2. ^{{Cite journal|last=Mihaly|first=S. R.|last2=Ninomiya-Tsuji|first2=J.|last3=Morioka|first3=S.|date=2014-11-01|title=TAK1 control of cell death|url=http://www.nature.com/cdd/journal/v21/n11/full/cdd2014123a.html|journal=Cell Death & Differentiation|language=en|volume=21|issue=11|pages=1667–1676|doi=10.1038/cdd.2014.123|issn=1350-9047|pmc=4211365|pmid=25146924}}
3. ^{{cite web | title = Entrez Gene: MAP3K7 mitogen-activated protein kinase kinase kinase 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6885| accessdate = }}
4. ^1 {{cite journal | vauthors = Mochida Y, Takeda K, Saitoh M, Nishitoh H, Amagasa T, Ninomiya-Tsuji J, Matsumoto K, Ichijo H | title = ASK1 inhibits interleukin-1-induced NF-kappa B activity through disruption of TRAF6-TAK1 interaction | journal = J. Biol. Chem. | volume = 275 | issue = 42 | pages = 32747–52 | date = October 2000 | pmid = 10921914 | doi = 10.1074/jbc.M003042200 }}
5. ^{{cite journal | vauthors = Sakurai H, Miyoshi H, Toriumi W, Sugita T | title = Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation | journal = J. Biol. Chem. | volume = 274 | issue = 15 | pages = 10641–8 | date = April 1999 | pmid = 10187861 | doi = 10.1074/jbc.274.15.10641}}
6. ^{{cite journal | vauthors = Wang C, Deng L, Hong M, Akkaraju GR, Inoue J, Chen ZJ | title = TAK1 is a ubiquitin-dependent kinase of MKK and IKK | journal = Nature | volume = 412 | issue = 6844 | pages = 346–51 | date = July 2001 | pmid = 11460167 | doi = 10.1038/35085597 }}
7. ^1 2 3 {{cite journal | vauthors = Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K | title = The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway | journal = Nature | volume = 398 | issue = 6724 | pages = 252–6 | date = March 1999 | pmid = 10094049 | doi = 10.1038/18465 }}
8. ^1 {{cite journal | vauthors = Sakurai H, Miyoshi H, Mizukami J, Sugita T | title = Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1 | journal = FEBS Lett. | volume = 474 | issue = 2–3 | pages = 141–5 | date = June 2000 | pmid = 10838074 | doi = 10.1016/s0014-5793(00)01588-x}}
9. ^{{cite journal | vauthors = Channavajhala PL, Wu L, Cuozzo JW, Hall JP, Liu W, Lin LL, Zhang Y | title = Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling | journal = J. Biol. Chem. | volume = 278 | issue = 47 | pages = 47089–97 | date = November 2003 | pmid = 12975377 | doi = 10.1074/jbc.M306002200 }}
10. ^1 2 {{cite journal | vauthors = Cheung PC, Nebreda AR, Cohen P | title = TAB3, a new binding partner of the protein kinase TAK1 | journal = Biochem. J. | volume = 378 | issue = Pt 1 | pages = 27–34 | date = February 2004 | pmid = 14670075 | pmc = 1223947 | doi = 10.1042/BJ20031794 }}
11. ^1 {{cite journal | vauthors = Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K | title = TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway | journal = Mol. Cell | volume = 5 | issue = 4 | pages = 649–58 | date = April 2000 | pmid = 10882101 | doi = 10.1016/s1097-2765(00)80244-0}}
12. ^1 {{cite journal | vauthors = Takaesu G, Ninomiya-Tsuji J, Kishida S, Li X, Stark GR, Matsumoto K | title = Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway | journal = Mol. Cell. Biol. | volume = 21 | issue = 7 | pages = 2475–84 | date = April 2001 | pmid = 11259596 | pmc = 86880 | doi = 10.1128/MCB.21.7.2475-2484.2001 }}
13. ^1 2 {{cite journal | vauthors = Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K | title = Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling | journal = EMBO J. | volume = 22 | issue = 23 | pages = 6277–88 | date = December 2003 | pmid = 14633987 | pmc = 291846 | doi = 10.1093/emboj/cdg605 }}
14. ^{{cite journal | vauthors = Kimura N, Matsuo R, Shibuya H, Nakashima K, Taga T | title = BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6 | journal = J. Biol. Chem. | volume = 275 | issue = 23 | pages = 17647–52 | date = June 2000 | pmid = 10748100 | doi = 10.1074/jbc.M908622199 }}
15. ^{{cite journal | vauthors = Yanagisawa M, Nakashima K, Takeda K, Ochiai W, Takizawa T, Ueno M, Takizawa M, Shibuya H, Taga T | title = Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7 | journal = Genes Cells | volume = 6 | issue = 12 | pages = 1091–9 | date = December 2001 | pmid = 11737269 | doi = 10.1046/j.1365-2443.2001.00483.x}}
16. ^{{cite journal | vauthors = Hanada M, Ninomiya-Tsuji J, Komaki K, Ohnishi M, Katsura K, Kanamaru R, Matsumoto K, Tamura S | title = Regulation of the TAK1 signaling pathway by protein phosphatase 2C | journal = J. Biol. Chem. | volume = 276 | issue = 8 | pages = 5753–9 | date = February 2001 | pmid = 11104763 | doi = 10.1074/jbc.M007773200 }}
17. ^{{cite journal | vauthors = Walsh MC, Kim GK, Maurizio PL, Molnar EE, Choi Y | title = TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL | journal = PLoS ONE | volume = 3 | issue = 12 | pages = e4064 | pmid = 19112497 | pmc = 2603309 | doi = 10.1371/journal.pone.0004064 | editor1-last = Unutmaz | editor1-first = Derya | year = 2008 }}
18. ^{{cite journal | vauthors = Sorrentino A, Thakur N, Grimsby S, Marcusson A, von Bulow V, Schuster N, Zhang S, Heldin CH, Landström M | title = The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner | journal = Nat. Cell Biol. | volume = 10 | issue = 10 | pages = 1199–207 | date = October 2008 | pmid = 18758450 | doi = 10.1038/ncb1780 }}

Further reading

{{refbegin |35em}}
  • {{cite journal | vauthors = DuBridge RB, Tang P, Hsia HC, Leong PM, Miller JH, Calos MP | title = Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system | journal = Mol. Cell. Biol. | volume = 7 | issue = 1 | pages = 379–87 | year = 1987 | pmid = 3031469 | pmc = 365079 | doi = 10.1128/mcb.7.1.379}}
  • {{cite journal | vauthors = Hirose T, Fujimoto W, Tamaai T, Kim KH, Matsuura H, Jetten AM | title = TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily | journal = Mol. Endocrinol. | volume = 8 | issue = 12 | pages = 1667–80 | year = 1995 | pmid = 7708055 | doi = 10.1210/me.8.12.1667 }}
  • {{cite journal | vauthors = Yamaguchi K, Shirakabe K, Shibuya H, Irie K, Oishi I, Ueno N, Taniguchi T, Nishida E, Matsumoto K | title = Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction | journal = Science | volume = 270 | issue = 5244 | pages = 2008–11 | year = 1996 | pmid = 8533096 | doi = 10.1126/science.270.5244.2008 }}
  • {{cite journal | vauthors = Shibuya H, Yamaguchi K, Shirakabe K, Tonegawa A, Gotoh Y, Ueno N, Irie K, Nishida E, Matsumoto K | title = TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction | journal = Science | volume = 272 | issue = 5265 | pages = 1179–82 | year = 1996 | pmid = 8638164 | doi = 10.1126/science.272.5265.1179 }}
  • {{cite journal | vauthors = Wang W, Zhou G, Hu MC, Yao Z, Tan TH | title = Activation of the hematopoietic progenitor kinase-1 (HPK1)-dependent, stress-activated c-Jun N-terminal kinase (JNK) pathway by transforming growth factor beta (TGF-beta)-activated kinase (TAK1), a kinase mediator of TGF beta signal transduction | journal = J. Biol. Chem. | volume = 272 | issue = 36 | pages = 22771–5 | year = 1997 | pmid = 9278437 | doi = 10.1074/jbc.272.36.22771 }}
  • {{cite journal | vauthors = Liu X, Sun Y, Constantinescu SN, Karam E, Weinberg RA, Lodish HF | title = Transforming growth factor β-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 20 | pages = 10669–74 | year = 1997 | pmid = 9380693 | pmc = 23442 | doi = 10.1073/pnas.94.20.10669 }}
  • {{cite journal | vauthors = Sakurai H, Shigemori N, Hasegawa K, Sugita T | title = TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase-independent mechanism | journal = Biochem. Biophys. Res. Commun. | volume = 243 | issue = 2 | pages = 545–9 | year = 1998 | pmid = 9480845 | doi = 10.1006/bbrc.1998.8124 }}
  • {{cite journal | vauthors = Yan ZH, Karam WG, Staudinger JL, Medvedev A, Ghanayem BI, Jetten AM | title = Regulation of peroxisome proliferator-activated receptor alpha-induced transactivation by the nuclear orphan receptor TAK1/TR4 | journal = J. Biol. Chem. | volume = 273 | issue = 18 | pages = 10948–57 | year = 1998 | pmid = 9556573 | doi = 10.1074/jbc.273.18.10948 }}
  • {{cite journal | vauthors = Lee FS, Peters RT, Dang LC, Maniatis T | title = MEKK1 activates both IκB kinase α and IκB kinase β | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 16 | pages = 9319–24 | year = 1998 | pmid = 9689078 | pmc = 21336 | doi = 10.1073/pnas.95.16.9319 }}
  • {{cite journal | vauthors = Yamaguchi K, Nagai S, Ninomiya-Tsuji J, Nishita M, Tamai K, Irie K, Ueno N, Nishida E, Shibuya H, Matsumoto K | title = XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway | journal = EMBO J. | volume = 18 | issue = 1 | pages = 179–87 | year = 1999 | pmid = 9878061 | pmc = 1171113 | doi = 10.1093/emboj/18.1.179 }}
  • {{cite journal | vauthors = Lallena MJ, Diaz-Meco MT, Bren G, Payá CV, Moscat J | title = Activation of IκB Kinase β by Protein Kinase C Isoforms | journal = Mol. Cell. Biol. | volume = 19 | issue = 3 | pages = 2180–8 | year = 1999 | pmid = 10022904 | pmc = 84010 | doi = 10.1128/MCB.19.3.2180}}
  • {{cite journal | vauthors = Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K | title = The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway | journal = Nature | volume = 398 | issue = 6724 | pages = 252–6 | year = 1999 | pmid = 10094049 | doi = 10.1038/18465 }}
  • {{cite journal | vauthors = Sakurai H, Miyoshi H, Toriumi W, Sugita T | title = Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation | journal = J. Biol. Chem. | volume = 274 | issue = 15 | pages = 10641–8 | year = 1999 | pmid = 10187861 | doi = 10.1074/jbc.274.15.10641 }}
  • {{cite journal | vauthors = Delhase M, Hayakawa M, Chen Y, Karin M | title = Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation | journal = Science | volume = 284 | issue = 5412 | pages = 309–13 | year = 1999 | pmid = 10195894 | doi = 10.1126/science.284.5412.309 }}
  • {{cite journal | vauthors = Zhou G, Lee SC, Yao Z, Tan TH | title = Hematopoietic progenitor kinase 1 is a component of transforming growth factor beta-induced c-Jun N-terminal kinase signaling cascade | journal = J. Biol. Chem. | volume = 274 | issue = 19 | pages = 13133–8 | year = 1999 | pmid = 10224067 | doi = 10.1074/jbc.274.19.13133 }}
  • {{cite journal | vauthors = Kimura N, Matsuo R, Shibuya H, Nakashima K, Taga T | title = BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6 | journal = J. Biol. Chem. | volume = 275 | issue = 23 | pages = 17647–52 | year = 2000 | pmid = 10748100 | doi = 10.1074/jbc.M908622199 }}
  • {{cite journal | vauthors = Yamamoto Y, Yin MJ, Gaynor RB | title = IκB Kinase α (IKKα) Regulation of IKKβ Kinase Activity | journal = Mol. Cell. Biol. | volume = 20 | issue = 10 | pages = 3655–66 | year = 2000 | pmid = 10779355 | pmc = 85658 | doi = 10.1128/MCB.20.10.3655-3666.2000 }}
  • {{cite journal | vauthors = Hofer-Warbinek R, Schmid JA, Stehlik C, Binder BR, Lipp J, de Martin R | title = Activation of NF-kappa B by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1 | journal = J. Biol. Chem. | volume = 275 | issue = 29 | pages = 22064–8 | year = 2000 | pmid = 10807933 | doi = 10.1074/jbc.M910346199 }}
  • {{cite journal | vauthors = Sakurai H, Miyoshi H, Mizukami J, Sugita T | title = Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1 | journal = FEBS Lett. | volume = 474 | issue = 2–3 | pages = 141–5 | year = 2000 | pmid = 10838074 | doi = 10.1016/S0014-5793(00)01588-X }}
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