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词条 MAP4
释义

  1. References

  2. Further reading

{{Infobox_gene}}Microtubule-associated protein 4 is a protein that in humans is encoded by the MAP4 gene.[1]

The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed, the full-length nature of three of which are supported.[2]

uMAP4, the ubiquitous isoform of MAP4, functions in the architecture and positioning of the mitotic spindle in human cells.[3] oMAP4 is predominantly expressed in brain and muscle and has been shown to organise microtubules into antiparallel bundles.[4] mMAP4 is a muscle-specific isoform.[4][5]

References

1. ^{{cite journal |vauthors=Chapin SJ, Bulinski JC | title = Non-neuronal 210 x 10(3) Mr microtubule-associated protein (MAP4) contains a domain homologous to the microtubule-binding domains of neuronal MAP2 and tau | series = 98 | journal = J Cell Sci | volume = ( Pt 1) | issue = | pages = 27–36 |date=Jul 1991 | pmid = 1905296 | pmc = | doi = }}
2. ^{{cite web | title = Entrez Gene: MAP4 microtubule-associated protein 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4134| accessdate = }}
3. ^{{cite journal|last1=Samora|first1=Catarina P.|last2=Mogessie|first2=Binyam|last3=Conway|first3=Leslie|last4=Ross|first4=Jennifer L.|last5=Straube|first5=Anne|last6=McAinsh|first6=Andrew D.|title=MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis|journal=Nature Cell Biology|date=7 August 2011|volume=13|issue=9|pages=1040–1050|doi=10.1038/ncb2297|pmid=21822276}}
4. ^1 {{cite journal|last1=Mogessie|first1=Binyam|last2=Roth|first2=Daniel|last3=Rahil|first3=Zainab|last4=Straube|first4=Anne|title=A novel isoform of MAP4 organises the paraxial microtubule array required for muscle cell differentiation|journal=eLife|date=21 April 2015|volume=4|pages=e05697|doi=10.7554/eLife.05697|pmid=25898002|pmc=4423121}}
5. ^{{cite journal|last1=Casey|first1=LM|last2=Lyon|first2=HD|last3=Olmsted|first3=JB|title=Muscle-specific microtubule-associated protein 4 is expressed early in myogenesis and is not sufficient to induce microtubule reorganization.|journal=Cell Motility and the Cytoskeleton|date=April 2003|volume=54|issue=4|pages=317–36|pmid=12601693|doi=10.1002/cm.10105}}

Further reading

{{refbegin | 2}}
  • {{cite journal |vauthors=Chapin SJ, Bulinski JC |title=Microtubule stabilization by assembly-promoting microtubule-associated proteins: a repeat performance. |journal=Cell Motil. Cytoskeleton |volume=23 |issue= 4 |pages= 236–43 |year= 1993 |pmid= 1477887 |doi= 10.1002/cm.970230403 }}
  • {{cite journal |vauthors=West RR, Tenbarge KM, Olmsted JB |title=A model for microtubule-associated protein 4 structure. Domains defined by comparisons of human, mouse, and bovine sequences. |journal=J. Biol. Chem. |volume=266 |issue= 32 |pages= 21886–96 |year= 1991 |pmid= 1718985 |doi= }}
  • {{cite journal |vauthors=Chapin SJ, Lue CM, Yu MT, Bulinski JC |title=Differential expression of alternatively spliced forms of MAP4: a repertoire of structurally different microtubule-binding domains. |journal=Biochemistry |volume=34 |issue= 7 |pages= 2289–301 |year= 1995 |pmid= 7857940 |doi=10.1021/bi00007a025 }}
  • {{cite journal |vauthors=Ookata K, Hisanaga S, Bulinski JC, etal |title=Cyclin B interaction with microtubule-associated protein 4 (MAP4) targets p34cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule dynamics. |journal=J. Cell Biol. |volume=128 |issue= 5 |pages= 849–62 |year= 1995 |pmid= 7876309 |doi=10.1083/jcb.128.5.849 | pmc=2120387 }}
  • {{cite journal |vauthors=Chapin SJ, Bulinski JC |title=Cellular microtubules heterogeneous in their content of microtubule-associated protein 4 (MAP4). |journal=Cell Motil. Cytoskeleton |volume=27 |issue= 2 |pages= 133–49 |year= 1994 |pmid= 7909279 |doi= 10.1002/cm.970270205 }}
  • {{cite journal |vauthors=Andersson B, Wentland MA, Ricafrente JY, etal |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
  • {{cite journal |vauthors=Illenberger S, Drewes G, Trinczek B, etal |title=Phosphorylation of microtubule-associated proteins MAP2 and MAP4 by the protein kinase p110mark. Phosphorylation sites and regulation of microtubule dynamics. |journal=J. Biol. Chem. |volume=271 |issue= 18 |pages= 10834–43 |year= 1996 |pmid= 8631898 |doi=10.1074/jbc.271.18.10834 }}
  • {{cite journal |vauthors=Yu W, Andersson B, Worley KC, etal |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 }}
  • {{cite journal |vauthors=Bulinski JC, McGraw TE, Gruber D, etal |title=Overexpression of MAP4 inhibits organelle motility and trafficking in vivo. | series=110 |journal=J. Cell Sci. |volume=( Pt 24) |issue= |pages= 3055–64 |year= 1998 |pmid= 9365275 |doi= }}
  • {{cite journal |vauthors=Ookata K, Hisanaga S, Sugita M, etal |title=MAP4 is the in vivo substrate for CDC2 kinase in HeLa cells: identification of an M-phase specific and a cell cycle-independent phosphorylation site in MAP4. |journal=Biochemistry |volume=36 |issue= 50 |pages= 15873–83 |year= 1998 |pmid= 9398320 |doi= 10.1021/bi971251w }}
  • {{cite journal |vauthors=Nguyen HL, Gruber D, Bulinski JC |title=Microtubule-associated protein 4 (MAP4) regulates assembly, protomer-polymer partitioning and synthesis of tubulin in cultured cells. | series=112 |journal=J. Cell Sci. |volume=( Pt 12) |issue= |pages= 1813–24 |year= 1999 |pmid= 10341201 |doi= }}
  • {{cite journal |vauthors=Ebneth A, Drewes G, Mandelkow EM, Mandelkow E |title=Phosphorylation of MAP2c and MAP4 by MARK kinases leads to the destabilization of microtubules in cells. |journal=Cell Motil. Cytoskeleton |volume=44 |issue= 3 |pages= 209–24 |year= 2000 |pmid= 10542369 |doi= 10.1002/(SICI)1097-0169(199911)44:3<209::AID-CM6>3.0.CO;2-4 }}
  • {{cite journal |vauthors=Kitazawa H, Iida J, Uchida A, etal |title=Ser787 in the proline-rich region of human MAP4 is a critical phosphorylation site that reduces its activity to promote tubulin polymerization. |journal=Cell Struct. Funct. |volume=25 |issue= 1 |pages= 33–9 |year= 2000 |pmid= 10791892 |doi=10.1247/csf.25.33 }}
  • {{cite journal |vauthors=Chang W, Gruber D, Chari S, etal |title=Phosphorylation of MAP4 affects microtubule properties and cell cycle progression. |journal=J. Cell Sci. |volume=114 |issue= Pt 15 |pages= 2879–87 |year= 2002 |pmid= 11683421 |doi= }}
  • {{cite journal |vauthors=Iida J, Itoh TJ, Hotani H, etal |title=The projection domain of MAP4 suppresses the microtubule-bundling activity of the microtubule-binding domain. |journal=J. Mol. Biol. |volume=320 |issue= 1 |pages= 97–106 |year= 2002 |pmid= 12079337 |doi= 10.1016/S0022-2836(02)00402-3 }}
  • {{cite journal |vauthors=Holmfeldt P, Brattsand G, Gullberg M |title=MAP4 counteracts microtubule catastrophe promotion but not tubulin-sequestering activity in intact cells. |journal=Curr. Biol. |volume=12 |issue= 12 |pages= 1034–9 |year= 2002 |pmid= 12123579 |doi=10.1016/S0960-9822(02)00897-7 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
  • {{cite journal |vauthors=Tokuraku K, Matsushima K, Matui T, etal |title=The number of repeat sequences in microtubule-associated protein 4 affects the microtubule surface properties. |journal=J. Biol. Chem. |volume=278 |issue= 32 |pages= 29609–18 |year= 2003 |pmid= 12773533 |doi= 10.1074/jbc.M302186200 }}
  • {{cite journal |vauthors=Mangan ME, Olmsted J |title=The gene for microtubule-associated protein 4 (Mtap4) maps to the distal region of mouse chromosome 9 |journal=Mamm. Genome |volume=7 |issue= 12 |pages= 918–19 |year= 1996 |pmid= 8995766 |doi= 10.1007/s003359900270 }}
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