“MAPK8IP1”的意思、由来-开放百科全书

The protein encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.^[3]

Interactions

MAPK8IP1 has been shown to interact with MAP3K10,^[4] DUSP16,^[5] Mitogen-activated protein kinase 9,^[4]^[6] MAPK8,^[6]^[7] LRP2,^[8]^[9] LRP1,^[8] MAP3K12,^[4] MAP2K7,^[4] MAPK8IP2^[4] and MAP3K11.^[4]

References

1. ^{{cite journal |vauthors=Dickens M, Rogers JS, Cavanagh J, Raitano A, Xia Z, Halpern JR, Greenberg ME, Sawyers CL, Davis RJ | title = A cytoplasmic inhibitor of the JNK signal transduction pathway | journal = Science | volume = 277 | issue = 5326 | pages = 693–6 |date=August 1997 | pmid = 9235893 | pmc = | doi =10.1126/science.277.5326.693 }}
2. ^{{cite journal |vauthors=Bonny C, Nicod P, Waeber G | title = IB1, a JIP-1-related nuclear protein present in insulin-secreting cells | journal = J Biol Chem | volume = 273 | issue = 4 | pages = 1843–6 |date=March 1998 | pmid = 9442013 | pmc = | doi =10.1074/jbc.273.4.1843 }}
3. ^{{cite web | title = Entrez Gene: MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9479| accessdate = }}
4. ^¹²³⁴⁵{{cite journal |last=Yasuda |first=J |authorlink= |author2=Whitmarsh A J |author3=Cavanagh J |author4=Sharma M |author5=Davis R J |date=October 1999 |title=The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins |journal=Mol. Cell. Biol. |volume=19 |issue=10 |pages=7245–54 | issn = 0270-7306| pmid = 10490659 |pmc=84717 |doi=10.1128/mcb.19.10.7245}}
5. ^{{cite journal |last=Willoughby |first=Emma A |authorlink= |author2=Perkins Gordon R |author3=Collins Mary K |author4=Whitmarsh Alan J |date=March 2003 |title=The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK |journal=J. Biol. Chem. |volume=278 |issue=12 |pages=10731–6 | issn = 0021-9258| pmid = 12524447 |doi = 10.1074/jbc.M207324200 }}
6. ^¹{{cite journal |last=Whitmarsh |first=A J |authorlink= |author2=Cavanagh J |author3=Tournier C |author4=Yasuda J |author5=Davis R J |date=September 1998 |title=A mammalian scaffold complex that selectively mediates MAP kinase activation |journal=Science |volume=281 |issue=5383 |pages=1671–4 | issn = 0036-8075| pmid = 9733513 |doi=10.1126/science.281.5383.1671}}
7. ^{{cite journal |last=Cai |first=Yi |authorlink= |author2=Lechner Mark S |author3=Nihalani Deepak |author4=Prindle Marc J |author5=Holzman Lawrence B |author6=Dressler Gregory R |date=January 2002 |title=Phosphorylation of Pax2 by the c-Jun N-terminal kinase and enhanced Pax2-dependent transcription activation |journal=J. Biol. Chem. |volume=277 |issue=2 |pages=1217–22 | issn = 0021-9258| pmid = 11700324 |doi = 10.1074/jbc.M109663200 }}
8. ^¹{{cite journal |last=Gotthardt |first=M |authorlink= |author2=Trommsdorff M |author3=Nevitt M F |author4=Shelton J |author5=Richardson J A |author6=Stockinger W |author7=Nimpf J |author8=Herz J |date=August 2000 |title=Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction |journal=J. Biol. Chem. |volume=275 |issue=33 |pages=25616–24 | issn = 0021-9258| pmid = 10827173 |doi = 10.1074/jbc.M000955200 }}
9. ^{{cite journal |last=Petersen |first=Helle Heibroch |authorlink= |author2=Hilpert Jan |author3=Militz Daniel |author4=Zandler Valerie |author5=Jacobsen Christian |author6=Roebroek Anton J M |author7=Willnow Thomas E |date=February 2003 |title=Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule |journal=J. Cell Sci. |volume=116 |issue=Pt 3 |pages=453–61 | issn = 0021-9533| pmid = 12508107 |doi=10.1242/jcs.00243 }}

Further reading

{{cite journal | author=Andersson B |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 |name-list-format=vanc| author2=Wentland MA | author3=Ricafrente JY | display-authors=3 | last4=Liu | first4=W | last5=Gibbs | first5=RA }}

{{cite journal | author=Yu W |title=Large-Scale Concatenation cDNA Sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 |name-list-format=vanc| author2=Andersson B | author3=Worley KC | display-authors=3 | last4=Muzny | first4=DM | last5=Ding | first5=Y | last6=Liu | first6=W | last7=Ricafrente | first7=JY | last8=Wentland | first8=MA | last9=Lennon | first9=G }}

{{cite journal | author=Whitmarsh AJ |title=A mammalian scaffold complex that selectively mediates MAP kinase activation |journal=Science |volume=281 |issue= 5383 |pages= 1671–4 |year= 1998 |pmid= 9733513 |doi=10.1126/science.281.5383.1671 |name-list-format=vanc| author2=Cavanagh J | author3=Tournier C | display-authors=3 | last4=Yasuda | first4=J | last5=Davis | first5=RJ }}

{{cite journal | author=Mooser V |title=Genomic organization, fine-mapping, and expression of the human islet-brain 1 (IB1)/c-Jun –amino-terminal kinase interacting protein-1 (JIP-1) gene |journal=Genomics |volume=55 |issue= 2 |pages= 202–8 |year= 1999 |pmid= 9933567 |doi= 10.1006/geno.1998.5641 |name-list-format=vanc| author2=Maillard A | author3=Bonny C | display-authors=3 | last4=Steinmann | first4=Myriam | last5=Shaw | first5=Philipp | last6=Yarnall | first6=David P. | last7=Burns | first7=Daniel K. | last8=Schorderet | first8=Daniel F. | last9=Nicod | first9=Pascal }}

{{cite journal | author=Yasuda J |title=The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins |journal=Mol. Cell. Biol. |volume=19 |issue= 10 |pages= 7245–54 |year= 2000 |pmid= 10490659 |doi= 10.1128/mcb.19.10.7245| pmc=84717 |name-list-format=vanc| author2=Whitmarsh AJ | author3=Cavanagh J | display-authors=3 | last4=Sharma | first4=M | last5=Davis | first5=RJ }}

{{cite journal |vauthors=Meyer D, Liu A, Margolis B |title=Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons |journal=J. Biol. Chem. |volume=274 |issue= 49 |pages= 35113–8 |year= 2000 |pmid= 10574993 |doi=10.1074/jbc.274.49.35113 }}

{{cite journal |vauthors=Kelkar N, Gupta S, Dickens M, Davis RJ |title=Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3 |journal=Mol. Cell. Biol. |volume=20 |issue= 3 |pages= 1030–43 |year= 2000 |pmid= 10629060 |doi=10.1128/MCB.20.3.1030-1043.2000 | pmc=85220 }}

{{cite journal | author=Waeber G |title=The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes |journal=Nat. Genet. |volume=24 |issue= 3 |pages= 291–5 |year= 2000 |pmid= 10700186 |doi= 10.1038/73523 |name-list-format=vanc| author2=Delplanque J | author3=Bonny C | display-authors=3 | last4=Mooser | first4=Vincent | last5=Steinmann | first5=Myriam | last6=Widmann | first6=Christian | last7=Maillard | first7=Anne | last8=Miklossy | first8=Judith | last9=Dina | first9=Christian }}

{{cite journal | author=Bonny C |title=IB1 reduces cytokine-induced apoptosis of insulin-secreting cells |journal=J. Biol. Chem. |volume=275 |issue= 22 |pages= 16466–72 |year= 2000 |pmid= 10748095 |doi= 10.1074/jbc.M908297199 |name-list-format=vanc| author2=Oberson A | author3=Steinmann M | display-authors=3 | last4=Schorderet | first4=DF | last5=Nicod | first5=P | last6=Waeber | first6=G }}

{{cite journal | author=Gotthardt M |title=Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25616–24 |year= 2000 |pmid= 10827173 |doi= 10.1074/jbc.M000955200 |name-list-format=vanc| author2=Trommsdorff M | author3=Nevitt MF | display-authors=3 | last4=Shelton | first4=J | last5=Richardson | first5=JA | last6=Stockinger | first6=W | last7=Nimpf | first7=J | last8=Herz | first8=J }}

{{cite journal | author=Bonny C |title=Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death |journal=Diabetes |volume=50 |issue= 1 |pages= 77–82 |year= 2001 |pmid= 11147798 |doi=10.2337/diabetes.50.1.77 |name-list-format=vanc| author2=Oberson A | author3=Negri S | display-authors=3 | last4=Sauser | first4=C. | last5=Schorderet | first5=D. F. }}

{{cite journal | author=Verhey KJ |title=Cargo of Kinesin Identified as Jip Scaffolding Proteins and Associated Signaling Molecules |journal=J. Cell Biol. |volume=152 |issue= 5 |pages= 959–70 |year= 2001 |pmid= 11238452 |doi=10.1083/jcb.152.5.959 | pmc=2198804 |name-list-format=vanc| author2=Meyer D | author3=Deehan R | display-authors=3 | last4=Blenis | first4=J. | last5=Schnapp | first5=B. J. | last6=Rapoport | first6=T. A. | last7=Margolis | first7=B. }}

{{cite journal | author=Matsuda S |title=c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK |journal=J. Neurosci. |volume=21 |issue= 17 |pages= 6597–607 |year= 2001 |pmid= 11517249 |doi= 10.1523/JNEUROSCI.21-17-06597.2001|name-list-format=vanc| author2=Yasukawa T | author3=Homma Y | display-authors=3 | last4=Ito | first4=Y | last5=Niikura | first5=T | last6=Hiraki | first6=T | last7=Hirai | first7=S | last8=Ohno | first8=S | last9=Kita | first9=Y }}

{{cite journal | author=Abderrahmani A |title=The Transcriptional Repressor REST Determines the Cell-Specific Expression of the Human MAPK8IP1 Gene Encoding IB1 (JIP-1) |journal=Mol. Cell. Biol. |volume=21 |issue= 21 |pages= 7256–67 |year= 2001 |pmid= 11585908 |doi= 10.1128/MCB.21.21.7256-7267.2001 | pmc=99900 |name-list-format=vanc| author2=Steinmann M | author3=Plaisance V | display-authors=3 | last4=Niederhauser | first4=G. | last5=Haefliger | first5=J.-A. | last6=Mooser | first6=V. | last7=Bonny | first7=C. | last8=Nicod | first8=P. | last9=Waeber | first9=G. }}

{{cite journal | author=Cai Y |title=Phosphorylation of Pax2 by the c-Jun N-terminal kinase and enhanced Pax2-dependent transcription activation |journal=J. Biol. Chem. |volume=277 |issue= 2 |pages= 1217–22 |year= 2002 |pmid= 11700324 |doi= 10.1074/jbc.M109663200 |name-list-format=vanc| author2=Lechner MS | author3=Nihalani D | display-authors=3 | last4=Prindle | first4=MJ | last5=Holzman | first5=LB | last6=Dressler | first6=GR }}

{{cite journal | author=Scheinfeld MH |title=Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP) |journal=J. Biol. Chem. |volume=277 |issue= 5 |pages= 3767–75 |year= 2002 |pmid= 11724784 |doi= 10.1074/jbc.M108357200 |name-list-format=vanc| author2=Roncarati R | author3=Vito P | display-authors=3 | last4=Lopez | first4=PA | last5=Abdallah | first5=M | last6=d'Adamio | first6=L }}

{{cite journal | author=Ikeda A |title=Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway |journal=J. Biochem. |volume=130 |issue= 6 |pages= 773–81 |year= 2002 |pmid= 11726277 |doi= 10.1093/oxfordjournals.jbchem.a003048|name-list-format=vanc| author2=Hasegawa K | author3=Masaki M | display-authors=3 | last4=Moriguchi | first4=T | last5=Nishida | first5=E | last6=Kozutsumi | first6=Y | last7=Oka | first7=S | last8=Kawasaki | first8=T }}

{{cite journal | author=Hashimoto M |title=alpha-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress-signaling pathway in neuronal cells |journal=J. Biol. Chem. |volume=277 |issue= 13 |pages= 11465–72 |year= 2002 |pmid= 11790792 |doi= 10.1074/jbc.M111428200 |name-list-format=vanc| author2=Hsu LJ | author3=Rockenstein E | display-authors=3 | last4=Takenouchi | first4=T | last5=Mallory | first5=M | last6=Masliah | first6=E }}