| 词条 | MAS1 oncogene |
| 释义 |
| Name = MAS1 oncogene | caption = | image = | width = | HGNCid = 6899 | Symbol = MAS1 | AltSymbols = | EntrezGene = 4142 | OMIM = 165180 | RefSeq = NM_002377 | UniProt = P04201 | PDB = | ECnumber = | Chromosome = 6 | Arm = q | Band = 24 | LocusSupplementaryData = -q27 }}{{infobox protein | Name = MAS1 oncogene-like | caption = | image = | width = | HGNCid = 13961 | Symbol = MAS1L | AltSymbols = | EntrezGene = 116511 | OMIM = 607235 | RefSeq = NM_052967 | UniProt = P35410 | PDB = | ECnumber = | Chromosome = 6 | Arm = p | Band = 21 | LocusSupplementaryData = }} The MAS1 oncogene is a G protein-coupled receptor[1] which binds the angiotensin-II metabolite Angiotensin (1-7).[2][3] The MAS1 receptor when activated by binding angiotensin-(1-7) opposes many of the effects of angiotensin-II activated angiotensin receptor. Hence MAS1 receptor agonists have similar therapeutic effects as angiotensin-II receptor antagonists including lowering blood pressure.[4] References1. ^{{cite journal |vauthors=Young D, Waitches G, Birchmeier C, Fasano O, Wigler M | title = Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains | journal = Cell | volume = 45 | issue = 5 | pages = 711–9 | year = 1986 | pmid = 3708691 | doi = 10.1016/0092-8674(86)90785-3 }} 2. ^{{cite journal |vauthors=Santos RA, Simoes e Silva AC, Maric C, Silva DM, Machado RP, de Buhr I, Heringer-Walther S, Pinheiro SV, Lopes MT, Bader M, Mendes EP, Lemos VS, Campagnole-Santos MJ, Schultheiss HP, Speth R, Walther T | title = Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 14 | pages = 8258–63 | year = 2003 | pmid = 12829792 | doi = 10.1073/pnas.1432869100 | pmc = 166216 }} 3. ^{{cite journal |vauthors=Santos RA, Ferreira AJ | title = Angiotensin-(1-7) and the renin-angiotensin system | journal = Curr. Opin. Nephrol. Hypertens. | volume = 16 | issue = 2 | pages = 122–8 | year = 2007 | pmid = 17293687 | doi = 10.1097/MNH.0b013e328031f362 }} 4. ^{{cite journal |vauthors=Santos RA, Ferreira AJ | title = Pharmacological effects of AVE 0991, a nonpeptide angiotensin-(1-7) receptor agonist | journal = Cardiovascular drug reviews | volume = 24 | issue = 3–4 | pages = 239–46 | year = 2006 | pmid = 17214600 | doi = 10.1111/j.1527-3466.2006.00239.x }} External links
|
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。