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词条 Mean platelet volume
释义

  1. Conditions associated with altered MPV

      Decreased MPV    Increased MPV  

  2. Inherited Thrombocytopenia with Normal MPV

  3. References

  4. External links

{{Refimprove|date=December 2009}}Mean platelet volume (MPV) is a machine-calculated measurement of the average size of platelets found in blood and is typically included in blood tests as part of the CBC. Since the average platelet size is larger when the body is producing increased numbers of platelets, the MPV test results can be used to make inferences about platelet production in bone marrow or platelet destruction problems.[1]

MPV is higher when there is destruction of platelets. This may be seen in inflammatory bowel disease,[2] immune thrombocytopenic purpura (ITP), myeloproliferative diseases and Bernard-Soulier syndrome. It may also be related to pre-eclampsia and recovery from transient hypoplasia.[3]

Abnormally low MPV values correlate with thrombocytopenia when it is due to impaired production as in aplastic anemia. In addition, low MPV can correlate with abnormally small platelet size, sometimes a symptom of a spectrum referred to as Wiskott-Aldrich Syndrome (WAS),[4] caused by a genetic mutation of the WAS gene.

Sample for MPV testing is obtained in a Lavender-Top EDTA tube. A typical range of platelet volumes is 9.4–12.3 fL[5] (femtolitre), equivalent to spheres 2.65 to 2.9 µm in diameter.

Conditions associated with altered MPV

Decreased MPV

  • Cytotoxic Chemotherapy
  • Hypersplenism
  • Reactive Thrombocytosis
  • Iron Deficiency Anemia
  • Hypothyroidism
  • Acquired Immunodeficiency Syndrome (AIDS)
  • Wiskott-Aldrich Syndrome
  • X-Linked Thrombocytopenia

Increased MPV

  • Immune Thrombocytopenia
  • Disseminated Intravascular Coagulation
  • Myeloproliferative Disorders
  • Administration of Erythropoietin / Thrombopoietin
  • Recovery from transient hypoplasia
  • Gray Platelet syndrome
  • GATA-1 mutation
  • vWD Type 2B
  • Platelet Type vWD
  • Paris-Trousseau Syndrome
  • Mediterranean Macrothrombocytopenia
  • Bernard-Soulier Syndrome[6]
  • MYH9-related disorders
  • 21q11 deletion syndrome
  • Acute & Chronic Myelogenous Leukemia
  • Post-Splenectomy
  • Vasculitis
  • Megaloblastic Anemia[7]
  • Diabetes Mellitus
  • Pre-eclampsia
  • Chronic Renal Failure
  • Respiratory Diseases
  • Thrombocytopenia secondary to Sepsis
  • Hyperthyroidism
  • Myocardial Infarction
  • Prosthetic Heart Valves
  • Massive Hemorrhage

Inherited Thrombocytopenia with Normal MPV

  • [https://books.google.com.pk/books?id=yF5WQdAcdfcC&pg=PA974&dq=atrus+syndrome&hl=en&sa=X&ved=0ahUKEwj258T4orrZAhWunOAKHblrB1UQ6AEINDAC#v=onepage&q=atrus%20syndrome&f=false ATRUS Syndrome]
  • Thrombocytopenia 2 (THC2)
  • Congenital Amegakaryocytic Thrombocytopenia
  • TAR Syndrome
  • Familial Platelet disorder with predisposition to AML

References

1. ^ , Lab Tests Online.
2. ^{{cite journal|last=Liu|first=S|author2=Ren, J |author3=Han, G |author4=Wang, G |author5=Gu, G |author6=Xia, Q |author7= Li, J |title=Mean platelet volume: a controversial marker of disease activity in Crohn's disease.|journal=European Journal of Medical Research|date=Oct 12, 2012|volume=17|pages=27|pmid=23058104|doi=10.1186/2047-783x-17-27 |pmc=3519557}}
3. ^[https://docs.google.com/viewer?a=v&q=cache:WD-fbfqdadUJ:www.metromedlab.com/SiteContent/Documents/File/IPN%2520MPV%2520%2520101609.pdf+%22mean+platelet+volume%22&hl=en&gl=us&pid=bl&srcid=ADGEESjXgOqNk6-jITg3Rn_c64mK0iSxOTrt5I6VycZ4yzlEf3z1ycjsY_1nU1H8hiYmppb3QKniYikKEIXM0CDCnwSvavxsO9wmKvgM2778hWm2McGaIv0Dz0GJzND39M3h3G29wxdw&sig=AHIEtbSsN2L1cvMZLM4tJ5snc9_uaKIADQ&pli=1], Arch Pathol Lab Med. Vol 133, September 2009;1441-43..
4. ^{{Cite web |url=https://primaryimmune.org/about-primary-immunodeficiencies/specific-disease-types/wiskott-aldrich-syndrome |title=Wiskott-Aldrich Syndrome |publisher=Immune Deficiency Foundation |access-date=2019-03-03}}
5. ^{{Cite web|url=https://www.healthcare.uiowa.edu/path_handbook/rhandbook/test299.html|title=CBC (Complete Blood Count), Blood|website=www.healthcare.uiowa.edu|access-date=2018-02-22}}
6. ^{{Cite web|url=https://emedicine.staging.medscape.com/article/954877-workup|title=Bernard-Soulier Syndrome Workup: Approach Considerations|website=emedicine.staging.medscape.com|language=en|access-date=2018-02-22}}
7. ^{{Cite book|url=https://books.google.com/?id=3PJVLH1NmQAC&pg=PA814&dq=megaloblastic+anemia+has+high+MPV#v=onepage&q=megaloblastic%20anemia%20has%20high%20MPV&f=false|title=Clinical Laboratory Medicine|last=McClatchey|first=Kenneth D.|date=2002|publisher=Lippincott Williams & Wilkins|isbn=9780683307511|language=en}}

External links

  •   Immune Deficiency Foundation entry for Wiskott-Aldrich Syndrome
  • MPV Definition
  •   Medicinenet.com: Thrombocytopenia
  •   Diabetesexplained.com: MPV
  •   ahajournals.org: Article related to MPV
  • {{cite journal | pmid = 4074887 | volume=11 | issue=1 | title=Use of mean platelet volume improves detection of platelet disorders | journal=Blood Cells | pages=127–35 | last1 = Bessman | first1 = JD | last2 = Gilmer | first2 = PR | last3 = Gardner | first3 = FH| year=1985 }}
  •   Wisegeekcom: What is Mean Platelet Volume
  •   Clinlabnavigator.com: MPV
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