| 词条 | Medication discontinuation |
| 释义 |
Unlike the prescribing of medications, appropriate discontinuation has not attracted nearly as much attention or interest.[6] End-of-life careMedications may be stopped in the context of end-of-life care, such as medications that may affect risk factors for future disease. Medications that may be stopped as part of discussions about end-of-life care include antihypertensives, medications for diabetes, and drugs for high cholesterol.[5] EffectsDrug discontinuation may cause rebound effects (return of the symptoms the drug relieved, and that, to a degree stronger than they were before treatment first began) and withdrawal syndromes (symptoms caused by the discontinuation by the drug itself). Drug discontinuation may be difficult to adjust to, owing to the long term use and the symbolism associated with ceasing medications, such as the decision to stop chemotherapy.[5] Recent research (Nixon & Vendelø, 2016) shows that General Practitioners (GPs) who actively consider discontinuation, are reluctant to do so, as they experience that the safest decision is to continue prescriptions, rather than discontinue them. In part this is due to the ambiguity about the appropriateness of discontinuing medication. The clinical guidelines available to GPs do not encourage discontinuation of medication, and thus, they offer GPs a weak frame for discontinuation. See also
References1. ^{{cite journal|last1=Raebel|first1=Marsha A.|last2=Schmittdiel|first2=Julie|last3=Karter|first3=Andrew J.|last4=Konieczny|first4=Jennifer L.|last5=Steiner|first5=John F.|title=Standardizing Terminology and Definitions of Medication Adherence and Persistence in Research employing Electronic Databases|journal=Medical Care|volume=51|issue=8 0 3|pages=S11-S21|date=Aug 2013|pmid=23774515|doi=10.1097/MLR.0b013e31829b1d2a|pmc=3727405}} 2. ^{{cite journal |last1=Abdullah-Koolmees |first1=Heshu |last2=Gardarsdottir |first2=Helga |last3=Yazir |first3=Dilek |last4=Stoker |first4=Lennart J. |last5=Vuyk |first5=Judith |last6=Egberts |first6=Toine C. G. |last7=Heerdink |first7=Eibert R. |title=Medication Discontinuation in Patients After Discharge From a Psychiatric Hospital |journal=Annals of Pharmacotherapy |date=9 July 2015 |volume=49 |issue=10 |pages=1085–1095 |doi=10.1177/1060028015593763}} 3. ^{{cite journal |last1=Nixon |first1=Michael |last2=Kousgaard |first2=Marius Brostrøm |title=Organising medication discontinuation: a qualitative study exploring the views of general practitioners toward discontinuing statins |journal=BMC Health Services Research |date=7 July 2016 |volume=16 |issue=1 |doi=10.1186/s12913-016-1495-2|pmc=4936268 }} 4. ^1 {{cite journal |last1=Linsky |first1=Amy |last2=Meterko |first2=Mark |last3=Stolzmann |first3=Kelly |last4=Simon |first4=Steven R. |title=Supporting medication discontinuation: provider preferences for interventions to facilitate deprescribing |journal=BMC Health Services Research |date=28 June 2017 |volume=17 |issue=1 |doi=10.1186/s12913-017-2391-0}} 5. ^1 2 {{cite journal |last1=Abel |first1=Julian |title=Withdrawing life-extending drugs at the end of life |journal=Prescriber |date=July 2013 |volume=24 |issue=13-16 |pages=17–20 |doi=10.1002/psb.1083}} 6. ^{{cite journal |last1=Bain |first1=Kevin T. |last2=Holmes |first2=Holly M. |last3=Beers |first3=Mark H. |last4=Maio |first4=Vittorio |last5=Handler |first5=Steven M. |last6=Pauker |first6=Stephen G. |title=Discontinuing Medications: A Novel Approach for Revising the Prescribing Stage of the Medication-Use Process |journal=Journal of the American Geriatrics Society |date=October 2008 |volume=56 |issue=10 |pages=1946–1952 |doi=10.1111/j.1532-5415.2008.01916.x}} 3 : Clinical pharmacology|Drugs|Pharmaceuticals policy |
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