| 词条 | Meglumine antimoniate |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 476995406 | IUPAC_name = Hydroxy-dioxostiborane; (2R,3R,4R,5S)-6-methylaminohexane-1,2,3,4,5-pentol | image = Meglumine antimoniate major component 3D.png | synonyms = Meglumine antimonate | tradename = | Drugs.com = {{drugs.com|CONS|meglumine_antimoniate}} | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 133-51-7 | ATC_prefix = P01 | ATC_suffix = CB01 | ATC_supplemental = {{ATCvet|P51|AB01}} | PubChem = 64953 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 58479 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 239129 | NIAID_ChemDB = 008733 | UNII_Ref = {{fdacite|changed|FDA}} | UNII = 75G4TW236W | chemical_formula = Variable | molecular_weight = Variable | SMILES = O=[Sb](=O)O.O[C@@H]([C@@H](O)[C@H](O)[C@@H](O)CNC)CO | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C7H17NO5.H2O.2O.Sb/c1-8-2-4(10)6(12)7(13)5(11)3-9;;;;/h4-13H,2-3H2,1H3;1H2;;;/q;;;;+1/p-1/t4-,5+,6+,7+;;;;/m0..../s1 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = XOGYVDXPYVPAAQ-SESJOKTNSA-M }}Meglumine antimoniate is a medicine used to treat leishmaniasis.[1] This includes visceral, mucocutaneous, and cutaneous leishmaniasis.[1] It is given by injection into a muscle or into the area infected.[1] Side effects include loss of appetite, nausea, abdominal pain, cough, feeling tired, muscle pain, irregular heartbeat, and kidney problems.[1] It should not be used in people with significant heart, liver, or kidney problems.[1] It is not recommended during breastfeeding.[1] It belongs to a group of medications known as the pentavalent antimonials.[1] Meglumine antimoniate came into medical use in 1946.[2] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[3] The wholesale cost in the developing world is about 4.32 USD per vial as of 2014.[4] It is available in Southern Europe and Latin America but not the United States.[5][6] Society and cultureIt is manufactured by Aventis[7] and sold as Glucantime in France, and Glucantim in Italy. See also
References1. ^1 2 3 4 5 6 {{cite book|title=WHO Model Formulary 2008|date=2009|publisher=World Health Organization|isbn=9789241547659|page=183|url=http://apps.who.int/medicinedocs/documents/s16879e/s16879e.pdf|accessdate=8 December 2016|deadurl=no|archiveurl=https://web.archive.org/web/20161213060118/http://apps.who.int/medicinedocs/documents/s16879e/s16879e.pdf|archivedate=13 December 2016|df=}} {{Excavata antiparasitics}}{{DEFAULTSORT:Meglumine Antimoniate}}{{portal bar|Pharmacy and pharmacology|Medicine}}2. ^{{cite book|last1=Sneader|first1=Walter|title=Drug Discovery: A History|date=2005|publisher=John Wiley & Sons|isbn=9780470015520|page=59|url=https://books.google.ca/books?id=jglFsz5EJR8C&pg=PA59|language=en|deadurl=no|archiveurl=https://web.archive.org/web/20161220082039/https://books.google.ca/books?id=jglFsz5EJR8C&pg=PA59|archivedate=2016-12-20|df=}} 3. ^{{cite web|title=WHO Model List of Essential Medicines (19th List)|url=http://www.who.int/medicines/publications/essentialmedicines/EML_2015_FINAL_amended_NOV2015.pdf?ua=1|work=World Health Organization|accessdate=8 December 2016|date=April 2015|deadurl=no|archiveurl=https://web.archive.org/web/20161213052708/http://www.who.int/medicines/publications/essentialmedicines/EML_2015_FINAL_amended_NOV2015.pdf?ua=1|archivedate=13 December 2016|df=}} 4. ^{{cite web|title=Meglumine Antimonate|url=http://mshpriceguide.org/en/single-drug-information/?DMFId=502&searchYear=2014|website=International Drug Price Indicator Guide|accessdate=8 December 2016}} 5. ^{{cite book|last1=Bope|first1=Edward T.|last2=Kellerman|first2=Rick D.|last3=Rakel|first3=Robert E.|title=Conn's Current Therapy 2011: Expert Consult|date=2010|publisher=Elsevier Health Sciences|isbn=143773572X|page=95|url=https://books.google.ca/books?id=pxnKBrfwTFYC&pg=PT128|language=en|deadurl=no|archiveurl=https://web.archive.org/web/20161220082035/https://books.google.ca/books?id=pxnKBrfwTFYC&pg=PT128|archivedate=2016-12-20|df=}} 6. ^{{cite book|last1=Gorbach|first1=Sherwood L.|last2=Bartlett|first2=John G.|last3=Blacklow|first3=Neil R.|title=Infectious Diseases|date=2004|publisher=Lippincott Williams & Wilkins|isbn=9780781733717|page=355|url=https://books.google.ca/books?id=91altE1evAsC&pg=PA355|language=en|deadurl=no|archiveurl=https://web.archive.org/web/20161220080917/https://books.google.ca/books?id=91altE1evAsC&pg=PA355|archivedate=2016-12-20|df=}} 7. ^Aventis press release {{webarchive|url=https://web.archive.org/web/20140522195924/http://www.sanofi.de/l/de/de/layout.jsp?cnt=38A41931-0260-4715-A7C3-25AD268B9C27 |date=2014-05-22 }}, 15 April 2005. {{de icon}} 4 : Antiprotozoal agents|Antimony compounds|World Health Organization essential medicines|RTT |
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