| 词条 | Membrane-bound transcription factor site-2 protease |
| 释义 |
| Name = membrane-bound transcription factor peptidase, site 2 | caption = | image = | width = | HGNCid = 15455 | Symbol = MBTPS2 | AltSymbols = S2P | EntrezGene = 51360 | OMIM = 300294 | RefSeq = NM_015884 | UniProt = O43462 | PDB = | ECnumber = 3.4.24.85 | Chromosome = X | Arm = p | Band = 22.1 | LocusSupplementaryData = -p22.2 }}{{Infobox enzyme | Name = S2P endopeptidase | EC_number = 3.4.24.85 | CAS_number = 752251-31-3 | IUBMB_EC_number = 3/4/24/85 | GO_code = | image = | width = | caption = }} Membrane-bound transcription factor site-2 protease, or site-2 protease (S2P) for short, is an enzyme ({{EC number|3.4.24.85}}) encoded by the {{gene|MBTPS2}} gene which liberates the N-terminal fragment of sterol regulatory element-binding protein (SREBP) transcription factors from membranes.[1][2] S2P cleaves the transmembrane domain of SREPB, making it a member of the class of intramembrane proteases. S2P endopeptidase ({{EC number|3.4.24.85}}) is an enzyme.[3] This enzyme catalyses the following chemical reactionCleaves several transcription factors that are type-2 transmembrane proteins within membrane-spanning domains. Known substrates include sterol regulatory element-binding protein (SREBP)-1, SREBP-2 and forms of the transcriptional activator ATF6. This enzyme belongs to the peptidase family M50. See also
References1. ^{{cite journal | vauthors = Brown MS, Goldstein JL | title = A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 20 | pages = 11041–8 | year = 1999 | pmid = 10500120 | doi = 10.1073/pnas.96.20.11041 | pmc = 34238 }} 2. ^{{cite journal | vauthors = Rawson RB, Zelenski NG, Nijhawan D, Ye J, Sakai J, Hasan MT, Chang TY, Brown MS, Goldstein JL | title = Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs | journal = Mol. Cell | volume = 1 | issue = 1 | pages = 47–57 | year = 1997 | pmid = 9659902 | doi = 10.1016/S1097-2765(00)80006-4 }} 3. ^{{cite journal | title = Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans |author1 = Brown, M.S. |author2 = Ye, J. |author3 = Rawson, R.B. |author4 = Goldstein, J.L. |journal = Cell |date = 2000 |volume = 100 |pages = 391–398 |pmid = 10693756 |doi=10.1016/S0092-8674(00)80675-3}} External links
1 : EC 3.4.24 |
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