| 词条 | Meptazinol |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 462248630 | IUPAC_name = (RS)-3-(3-Ethyl-1-methylazepan-3-yl)phenol | image = Meptazinol.svg | width = 150 | chirality = Racemic mixture | tradename = Meptid | Drugs.com = {{drugs.com|international|meptazinol}} | licence_EU = | licence_US = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = Schedule 4 | legal_CA = | legal_UK = POM | legal_US = | legal_status = | dependency_liability = Low | routes_of_administration = Oral, IM, IV | bioavailability = | protein_bound = | metabolism = The peak analgesic effect is seen within 30–60 minutes and lasts about 3–4 hours | elimination_half-life = Half-life (1.4–4 hours) | excretion = The drug is rapidly metabolized to the glucuronide, and mostly excreted in the urine | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 59263-76-2 | ATC_prefix = N02 | ATC_suffix = AX05 | ATC_supplemental = | PubChem = 41049 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 37469 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 18Y7S5JKZD | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D08182 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 314437 | C=15 | H=23 | N=1 | O=1 | smiles = OC1=CC=CC(C2(CCCCN(C2)C)CC)=C1 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C15H23NO/c1-3-15(9-4-5-10-16(2)12-15)13-7-6-8-14(17)11-13/h6-8,11,17H,3-5,9-10,12H2,1-2H3 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = JLICHNCFTLFZJN-UHFFFAOYSA-N | synonyms = | density = | melting_notes = | boiling_point = | solubility = | specific_rotation = | sec_combustion = }} Meptazinol (trade name Meptid) is an opioid analgesic developed by Wyeth in the 1970s.[1] Indications for use in moderate to severe pain, most commonly used to treat pain in obstetrics (childbirth). Meptazinol is a 3-phenylazepane derivative, whereas the other phenazepanes like ethoheptazine and proheptazine are 4-phenylazepanes. A partial µ-opioid receptor agonist, its mixed agonist/antagonist activity affords it a lower risk of dependence and abuse than full µ agonists like morphine. Meptazinol exhibits not only a short onset of action, but also a shorter duration of action relative to other opioids such as morphine, pentazocine, or buprenorphine.[2] References1. ^{{ cite patent | country = US | status = patent | number = 4197239 | title = Hexahydroazepine, Piperidine and Pyrrolidine Derivatives | gdate = 1980-04-08 | inventor = Cavalla JF, Shepherd RG, White AC | assign1 = Wyeth }} 2. ^{{ cite journal |vauthors=Holmes B, Ward A | title = Meptazinol. A Review of its Pharmacodynamic and Pharmacokinetic Properties and Therapeutic Efficacy | journal = Drugs | year = 1985 | volume = 30 | issue = 4 | pages = 285–312 | pmid = 2998723 | doi=10.2165/00003495-198530040-00001}} External links
3 : Synthetic opioids|Azepanes|Phenols |
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