| 词条 | Mesuximide |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 411374493 | IUPAC_name = (RS)-1,3-dimethyl-3-phenyl-pyrrolidine-2,5-dione | image = Mesuximide.svg | width = 150 | chirality = Racemic mixture | tradename = Celontin | Drugs.com = {{drugs.com|CDI|methsuximide}} | MedlinePlus = a682028 | pregnancy_US = C | legal_US = Rx-only | routes_of_administration = By mouth (capsules) | metabolism = Hepatic (demethylation and glucuronidation) | metabolites = N-desmethylmethosuximide | elimination_half-life = 1.4–2.6 hours (mesuximide) 28–38 hours (active metabolite) | excretion = Urine | IUPHAR_ligand = 7228 | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 77-41-8 | ATC_prefix = N03 | ATC_suffix = AD03 | PubChem = 6476 | DrugBank_Ref = {{drugbankcite|changed|drugbank}} | DrugBank = DB05246 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 6231 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 0G76K8X6C0 | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D00404 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 697 | C=12 | H=13 | N=1 | O=2 | molecular_weight = 203.237 g/mol | smiles = O=C2N(C(=O)CC2(c1ccccc1)C)C | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C12H13NO2/c1-12(9-6-4-3-5-7-9)8-10(14)13(2)11(12)15/h3-7H,8H2,1-2H3 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = AJXPJJZHWIXJCJ-UHFFFAOYSA-N }}Mesuximide (or methsuximide, methosuximide) is a succinimide anticonvulsant medication. It is sold as a racemate by Pfizer under the tradenames Petinutin (Switzerland)[1] and Celontin (United States).[2] The therapeutic efficacy of methosuximide is largely due to its pharmacologically active metabolite, N-desmethylmethosuximide, which has a longer half-life and attains much higher plasma levels than its parent.[3] Medical useis indicated for the control of absence seizures that are refractory to other drugs.[2] References1. ^{{cite web|author=Pfizer AG |year=2005 |url=http://www.pfizer.ch/internet/fr/home/products/central_nervous_system/epilepsy/petinutin_mesuximid.html |title=Petinutin (Mésuximide) |work=Official Pfizer AG Website |accessdate=August 21, 2006 |language=French |deadurl=yes |archiveurl=https://web.archive.org/web/20050422010830/http://www.pfizer.ch/internet/fr/home/products/central_nervous_system/epilepsy/petinutin_mesuximid.html |archivedate=April 22, 2005 }} {{Anticonvulsants}}{{anticonvulsant-stub}}2. ^1 {{cite web | author = Pfizer Inc. | year = 2008 | url = http://labeling.pfizer.com/ShowLabeling.aspx?id=555 | title = Celontin (methsuximide capsules, USP) | work = Official Pfizer Inc. Website | accessdate = November 21, 2014 | language = }} 3. ^Porter RJ, Penry JK, Lacy JR, Newmark ME, Kupferberg HJ. Plasma concentrations of phensuximide, methosuximide, and their metabolites in relation to clinical efficacy. Neurology 29: 1509-1513, 1979. 2 : Anticonvulsants|Succinimides |
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