词条 | Metanephrogenic blastema |
释义 |
| Name = Metanephrogenic blastema | Latin = blastema metanephrogenicum | Image = | Caption = | Image2 = | Caption2 = | System = | Days = 35 | CarnegieStage = 14 | Precursor = Wolffian duct | GivesRiseTo = nephron (Bowman's capsule, connecting tubule, distal convoluted tubule, glomerulus, loop of Henle, proximal convoluted tubule), but not collecting duct }} The metanephrogenic blastema or metanephric blastema (or metanephric mesenchyme, or metanephric mesoderm) is one of the two embryological structures that give rise to the kidney, the other being the ureteric bud. The metanephric blastema mostly develops into nephrons, but can also form parts of the collecting duct system. The system of tissue induction between the ureteric bud and the metanephric blastema is a reciprocal control system. GDNF, gonadal derived neurotrophic factor, is produced by the metanephric blastema and is essential in binding to the Ret receptor on the ureteric bud, which bifurcates and coalesces as a result to form the renal pelvis, major and minor calyces and collecting ducts. Mutations in the EYA1 gene, which is a GDNF transcription factor, lead to the renal abnormalities of BOR syndrome (branchio-oto-renal syndrome). See also
External links
1 : Embryology |
随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识,基本涵盖了大多数领域的百科知识,是一部内容自由、开放的电子版国际百科全书。