| 词条 | Methanofuran |
| 释义 |
Methanofurans are a family of chemical compounds found in methanogenic archaea.[1] These species feature a 2-aminomethylfuran linked to phenoxy group. At least three different end groups are recognized: R = tricarboxyheptanoyl (methanofuran), glutamyl-glutamyl (methanofuran b), tricarboxy-2-hydroxyheptanoyl (methanofuran c, see picture). Formylation of MFRMethanofuran converts to formylmethanofuran in an early stage of methanogenesis. The enzyme formylmethanofuran dehydrogenase (EC: 1.2.99.5) formylates methanofuran using {{chem|CO|2}}, the primary C1 source in methanogenesis.[2] Deformylation of MFRThe enzyme formylmethanofuran:tetrahydromethanopterin formyltransferase catalyzes the transfer of the formyl group from formylmethanofuran to N5 on tetrahydromethanopterin, {{chem|H|4|MPT}}. This enzyme has been crystallized; it contains no prosthetic group.[3] References1. ^{{cite journal |author=Thauer RK |title=Biochemistry of methanogenesis: a tribute to Marjory Stephenson. 1998 Marjory Stephenson Prize Lecture |journal=Microbiology |volume=144 |issue=Pt 9 |pages=2377–406 |date=September 1998 |pmid=9782487 |url=http://mic.sgmjournals.org/cgi/pmidlookup?view=long&pmid=9782487 |doi=10.1099/00221287-144-9-2377}} {{Enzyme cofactors}}2. ^{{cite journal |vauthors=Vorholt JA, Thauer RK |author-link=Julia Vorholt |title=The active species of {{chem|CO|2}} utilized by formylmethanofuran dehydrogenase from methanogenic Archaea |journal=Eur. J. Biochem. |volume=248 |issue=3 |pages=919–24 | date=September 1997 |pmid=9342247 |doi=10.1111/j.1432-1033.1997.00919.x}} 3. ^{{cite journal |vauthors=Acharya P, Warkentin E, Ermler U, Thauer RK, Shima S |title=The structure of formylmethanofuran: tetrahydromethanopterin formyltransferase in complex with its coenzymes |journal=J. Mol. Biol. |volume=357 |issue=3 |pages=870–9 |date=March 2006 |pmid=16466742 |doi=10.1016/j.jmb.2006.01.015 |url=http://linkinghub.elsevier.com/retrieve/pii/S0022-2836(06)00043-X}} 3 : Amines|Peptides|Coenzymes |
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