词条 | Methdilazine |
释义 |
| Verifiedfields = changed | verifiedrevid = 462249764 | IUPAC_name = 10-[(1-methylpyrrolidin-3-yl) methyl]- 10H-phenothiazine | image = Methdilazine.svg | tradename = | Drugs.com = {{drugs.com|monograph|promethazine-hydrochloride}} | pregnancy_category = | legal_status = | bioavailability = | metabolism = | elimination_half-life = | excretion = | IUPHAR_ligand = 7231 | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 1982-37-2 | ATC_prefix = R06 | ATC_suffix = AD04 | PubChem = 14677 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = DB00902 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 14009 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 4Q13LY9Z8X | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D04979 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 1200959 | C=18 | H=20 | N=2 | S=1 | molecular_weight = 296.431 g/mol | smiles = S2c1ccccc1N(c3c2cccc3)CC4CCN(C)C4 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C18H20N2S/c1-19-11-10-14(12-19)13-20-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)20/h2-9,14H,10-13H2,1H3 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = HTMIBDQKFHUPSX-UHFFFAOYSA-N }} Methdilazine (Dilosyn, Tacaryl) is a first-generation antihistamine with anticholinergic properties of the phenothiazine class. SynthesisSee also
References1. ^L. W. Marsch and R. Peterson, Arzneimittel Forsch., 9, 715 (1959).
The ring-contracted analog, methdilazine shows only very weak activity as a tranquilizer; instead, that agent constitutes an important antihistamine. {{Antihistamines}}{{Cholinergics}}{{Histaminergics}}{{Tricyclics}}{{respiratory-system-drug-stub}} 3 : Phenothiazines|Pyrrolidines|H1 receptor antagonists |
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