“Methylarsonate reductase”的意思、由来-开放百科全书

词条

Methylarsonate reductase

释义

References

{{enzyme
| Name = methylarsonate reductase
| EC_number = 1.20.4.2
| CAS_number =
| IUBMB_EC_number = 1/20/4/2
| GO_code = 0050610
| image =
| width =
| caption =
}}

In enzymology, a methylarsonate reductase ({{EC number|1.20.4.2}}) is an enzyme that catalyzes the chemical reaction

methylarsonate + 2 glutathione methylarsonite + glutathione disulfide + H₂O

Thus, the two substrates of this enzyme are methylarsonate and glutathione, whereas its 3 products are methylarsonite, glutathione disulfide, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on phosphorus or arsenic in donor with disulfide as acceptor. The systematic name of this enzyme class is gluthathione:methylarsonate oxidoreductase. This enzyme is also called MMA(V) reductase.

References

{{cite journal |vauthors=Zakharyan RA, Aposhian HV | date = 1999 | title = Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase | journal = Chem. Res. Toxicol. | volume = 12 | pages = 1278–83 | pmid = 10604879 | doi = 10.1021/tx9901231 | issue = 12 }}

2 : EC 1.20.4|Enzymes of unknown structure

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