“Methylated-DNA—(protein)-cysteine S-methyltransferase”的意思、由来-开放百科全书

词条

Methylated-DNA—(protein)-cysteine S-methyltransferase

释义

Structural studies
References

{{enzyme
| Name = methylated-DNA-[protein]-cysteine S-methyltransferase
| EC_number = 2.1.1.63
| CAS_number = 77271-19-3
| IUBMB_EC_number = 2/1/1/63
| GO_code = 0003908
| image =
| width =
| caption =
}}

In enzymology, a methylated-DNA-[protein]-cysteine S-methyltransferase ({{EC number|2.1.1.63}}) is an enzyme that catalyzes the chemical reaction

DNA (containing 6-O-methylguanine) + protein L-cysteine DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine

Thus, the two substrates of this enzyme are DNA containing 6-O-methylguanine and protein L-cysteine, whereas its two products are DNA and protein S-methyl-L-cysteine. The S-methyl-L-cysteine residue irreversibly inactivates the protein, allowing only one transfer for each protein.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is DNA-6-O-methylguanine:[protein]-L-cysteine S-methyltransferase.

Structural studies

As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1EH6}}, {{PDB link|1EH7}}, {{PDB link|1EH8}}, {{PDB link|1MGT}}, {{PDB link|1QNT}}, {{PDB link|1SFE}}, {{PDB link|1T38}}, {{PDB link|1T39}}, {{PDB link|1WRJ}}, {{PDB link|1YFH}}, and {{PDB link|2G7H}}.

References

{{cite journal | vauthors = Foote RS, Mitra S, Pal BC | year = 1980 | title = Demethylation of O6-methylguanine in a synthetic DNA polymer by an inducible activity in Escherichia coli | journal = Biochem. Biophys. Res. Commun. | volume = 97 | pages = 654–9 | pmid = 7008792 | doi = 10.1016/0006-291X(80)90314-9 | issue = 2 }}
{{cite journal | vauthors = Olsson M, Lindahl T | year = 1980 | title = Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O6-methylguanine to a protein cysteine residue | journal = J. Biol. Chem. | volume = 255 | pages = 10569–71 | pmid = 7000780 | issue = 22 }}
{{cite journal | vauthors = Pegg AE, Byers TL | year = 1992 | title = Repair of DNA containing O6-alkylguanine | journal = FASEB J. | volume = 6 | pages = 2302–10 | pmid = 1544541 | issue = 6 }}

{{One carbon transferases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{DEFAULTSORT:Methylated-DNA-(protein)-cysteine S-methyltransferase}}{{2.1-enzyme-stub}}

2 : EC 2.1.1|Enzymes of known structure

随便看

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。