| 词条 | Metildigoxin |
| 释义 |
| verifiedrevid = 443935395 | IUPAC_name = (3β,5β,12β)-3[2,6-dideoxy-4-O-methyl-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl]oxy12,14-dihydroxycard-20(22)-enolide | image = medigoxin.png | tradename = | Drugs.com = {{drugs.com|international|medigoxin}} | pregnancy_category = C | legal_status = | routes_of_administration = | bioavailability = | metabolism = | excretion = | CAS_number = 30685-43-9 | ATC_prefix = C01 | ATC_suffix = AA08 | PubChem = 443946 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 392000 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = I7GG1YUC5V | C=42 | H=66 | O=14 | molecular_weight = 794.965 | smiles = O=C\\1OC/C(=C/1)[C@H]2CC[C@@]8(O)[C@]2(C)[C@H](O)C[C@H]7[C@H]8CC[C@H]6[C@]7(C)CC[C@H](O[C@@H]5O[C@H](C)[C@@H](O[C@@H]4O[C@@H]([C@@H](O[C@@H]3O[C@@H]([C@@H](OC)[C@@H](O)C3)C)[C@@H](O)C4)C)[C@@H](O)C5)C6 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C42H66O14/c1-20-37(49-6)29(43)16-35(51-20)55-39-22(3)53-36(18-31(39)45)56-38-21(2)52-34(17-30(38)44)54-25-9-11-40(4)24(14-25)7-8-27-28(40)15-32(46)41(5)26(10-12-42(27,41)48)23-13-33(47)50-19-23/h13,20-22,24-32,34-39,43-46,48H,7-12,14-19H2,1-6H3/t20-,21-,22-,24-,25+,26-,27-,28+,29+,30+,31+,32-,34+,35+,36+,37-,38-,39-,40+,41+,42+/m1/s1 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = IYJMSDVSVHDVGT-PEQKVOOWSA-N | synonyms = 4-[(3S,5R,8R,9S,10S,12R,13S,14S)-12,14-Dihydroxy-3-[(2R,4S,5S,6R)-4-hydroxy-5-[(2S,4S,5S,6R)-4-hydroxy-5-[(2S,4S,5S,6R)-4-hydroxy-5-methoxy-6-methyl-oxan-2-yl]oxy-6-methyl-oxan-2-yl]oxy-6-methyl-oxan-2-yl]oxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-5H-furan-2-one }} Metildigoxin (INN, or medigoxin BAN, or methyldigoxin) is a cardiac glycoside,[1] a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). The substance is closely related to digoxin; it differs from the latter only by an O-methyl group on the terminal monosaccharide. References1. ^{{Cite journal | last1 = Hayward | first1 = R. | last2 = Greenwood | first2 = H. | last3 = Stephens | first3 = J. | last4 = Hamer | first4 = J. | title = Relationship between myocardial uptake and actions in heart failure of methyldigoxin | journal = British Journal of Clinical Pharmacology | volume = 15 | issue = 1 | pages = 41–48 | year = 1983 | pmid = 6849743 | pmc = 1427830 | doi=10.1111/j.1365-2125.1983.tb01461.x}} {{Cardiac glycosides}}{{cardiovascular-drug-stub}} 2 : Antiarrhythmic agents|Cardenolides |
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