MHSA may refer to

• California Mental Health Services Act, legislation designed to expand and transform California’s county mental health service systems
• Main Hoon Shahid Afridi, a 2013 Pakistani sports action-drama film
• Milwaukee High School of the Arts, a high school in Milwaukee, Wisconsin
• Montana High School Association, the governing body of high school athletics in the state of Montana

• Miss Hong Kong 2012
• Miss Hong Kong 2016
• Miss Hong Kong 2017
• Miss Hong Kong 2018
• Miss. Hustle
• Missiamma
• Miss Idaho's Outstanding Teen
• Missie
• Missie Misomali
• Missile (1987 film)
• Missile (2016 film)
• Missile and Munitions Center and School
• Missile Approach Warner
• Missile Approach Warning
• Missile Attack
• Missile boat Šibenik (RTOP-21)
• Missile camouflage
• Missile Command 3D
• Missile Defender
• Missile farm
• Missile (film)
• Missile Ministry
• Missile Moyenne Portee
• Missile row
• Missile Scare