“Mir-103/107 microRNA precursor”的意思、由来-开放百科全书

The miR-103 microRNA precursor (homologous to miR-107), is a short non-coding RNA gene involved in gene regulation.

miR-103 and miR-107 have now been predicted or experimentally confirmed in human.^[1]^[2]

microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes from

the 5' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to mRNA.^[3]

mir-103 and mir-107 were noted as being upregulated in obese mice and were subsequently found to have a key role in insulin sensitivity. This led to a suggestion that these microRNAs represent potential targets for the treatment of type 2 diabetes.^[4]

mir-103 has also been linked with chronic pain^[5] and intestinal cell proliferation.^[6]

Recently, miR-103-3p was shown to target the 5' untranslated region (5' UTR) of GPRC5A's mRNA in pancreatic cancer.^[7] This is one of only a handful of known instances where a miRNA targets the 5' UTR of a mRNA.

References

1. ^{{cite journal |author=Mourelatos Z |title=miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs |journal=Genes Dev. |volume=16 |issue=6 |pages=720–8 |year=2002 |pmid=11914277 |doi=10.1101/gad.974702 |pmc=155365 |name-list-format=vanc|author2=Dostie J |author3=Paushkin S |display-authors=3 |last4=Sharma |first4=A |last5=Charroux |first5=B |last6=Abel |first6=L |last7=Rappsilber |first7=J |last8=Mann |first8=M |last9=Dreyfuss |first9=G}}
2. ^{{cite web|title=miRNA gene family: mir-103|url=http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000024|work=mirBASE|publisher=University of Manchester|accessdate=5 September 2011|deadurl=yes|archiveurl=https://archive.is/20120710015407/http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000024|archivedate=10 July 2012|df=}}
3. ^{{cite journal |author=Ambros V |title=microRNAs: tiny regulators with great potential |journal=Cell |volume=107 |issue=7 |pages=823–6 |year=2001 |pmid=11779458 |doi=10.1016/S0092-8674(01)00616-X}}
4. ^{{cite journal|last=Trajkovski|first=M|author2=Hausser, J |author3=Soutschek, J |author4=Bhat, B |author5=Akin, A |author6=Zavolan, M |author7=Heim, MH |author8=Stoffel, M |title=MicroRNAs 103 and 107 regulate insulin sensitivity|journal=Nature|date=Jun 8, 2011|volume=474|issue=7353|pages=649–53|pmid=21654750|doi=10.1038/nature10112|url=https://archive-ouverte.unige.ch/unige:30806/ATTACHMENT01}}
5. ^{{cite journal|last=Favereaux|first=A |author2=Thoumine, O |author3=Bouali-Benazzouz, R |author4=Roques, V |author5=Papon, MA |author6=Salam, SA |author7=Drutel, G |author8=Léger, C |author9=Calas, A |author10=Nagy, F |author11=Landry, M|title=Bidirectional integrative regulation of Cav1.2 calcium channel by microRNA miR-103: role in pain|journal=The EMBO Journal|date=Jul 29, 2011|pmid=21804529|volume=30|issue=18|pages=3830–41|doi=10.1038/emboj.2011.249|pmc=3173784}}
6. ^{{cite journal|last=Liao|first=Y|author2=Lönnerdal, B|title=Global MicroRNA Characterization Reveals That miR-103 Is Involved in IGF-1 Stimulated Mouse Intestinal Cell Proliferation|journal=PLoS ONE|date=Sep 23, 2010|volume=5|issue=9|pages=e12976|pmid=20886090|doi=10.1371/journal.pone.0012976|pmc=2944884|editor1-last=Langsley|editor1-first=Gordon}}
7. ^{{cite journal|last=Zhou|first=H|author2=Rigoutsos, I |title=MiR-103a-3p targets the 5′ UTR of GPRC5A in pancreatic cells|journal=RNA|date=Jul 1, 2014|pmid=24984703|doi=10.1261/rna.045757.114|volume=20|pages=1431–9|pmc=4138326}}

References

External links