请输入您要查询的百科知识：

　

词条 Mir-10 microRNA precursor family
释义

  1. Species distribution

  2. Genomic location

  3. miR-10*

  4. Pattern of expression

  5. Targets of miR-10

  6. Association with cancer

  7. See also

  8. References

  9. Further reading

  10. External links

{{Infobox rfam
| Name = mir-10
| image = MiR-10_consensus_structure.jpg
| width = 220px
| caption = Conserved secondary structure of the mir-10 miRNA. Including marking up the mature miR and miR* sequences and corresponding seeds.
| Symbol = miR-10
| AltSymbols = miR-51, miR-57, miR-99, miR-100
| Rfam = RF00104
| miRBase_family = MIPF0000033
| RNA_type = microRNA
| Tax_domain = Eukaryota; Metazoa
| HGNCid = 31497
| OMIM = 610173
}}

The miR-10 microRNA precursor is a short non-coding RNA gene involved in gene regulation. It is part of an RNA gene family which contains miR-10, miR-51, miR-57, miR-99 and miR-100. miR-10, miR-99 and miR-100 have now been predicted or experimentally confirmed in a wide range of species.[1][2] (MIPF0000033{{dead link|date=February 2018 |bot=InternetArchiveBot |fix-attempted=yes }}, MIPF0000025{{dead link|date=February 2018 |bot=InternetArchiveBot |fix-attempted=yes }}) mir-51 and mir-57 have currently only been identified in the nematode Caenorhabditis elegans (MIPF0000268{{dead link|date=February 2018 |bot=InternetArchiveBot |fix-attempted=yes }}, MIPF0000271{{dead link|date=February 2018 |bot=InternetArchiveBot |fix-attempted=yes }}).

MicroRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes from the 5' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to mRNA.

Species distribution

The presence of miR-10 has been detected in a diverse range of bilaterian animals. It is one of the most widely distributed microRNAs in animals, it has been identified in numerous species including human, dog, cat, horse, cow, guinea pig, mouse, rat, common marmoset (Callithrix jacchus), common chimpanzee (Pan troglodytes), rhesus monkey (Macaca mulatta), Sumatran orangutan (Pongo abelii), northern greater galago (Otolemur garnettii), gray short-tailed opossum (Monodelphis domestica), northern treeshrew (Tupaia belangeri), European rabbit (Oryctolagus cuniculus), African bush elephant (Loxodonta africana), nine-banded armadillo (Dasypus novemcinctus), European hedgehog (Erinaceus europaeus), lesser hedgehog tenrec (Echinops telfairi), zebra finch (Taeniopygia guttata), chicken, platypus (Ornithorhynchus anatinus), Western clawed frog (Xenopus tropicalis), Carolina anole (Anolis carolinensis), zebrafish (Danio rerio), Japanese pufferfish (Fugu rubripes), green spotted pufferfish (Tetraodon nigroviridis), Japanese killifish (Oryzias latipes), three-spined stickleback (Gasterosteus aculeatus), Florida lancelet (Branchiostoma floridae), California purple sea urchin (Strongylocentrotus purpuratus), 12 different species of fruit fly (Drosophila), Western honey bee (Apis mellifera), mosquito (Anopheles gambiae), red flour beetle (Tribolium castaneum), the nematode Caenorhabditis elegans, owl limpet (Lottia gigantea), starlet sea anemone (Nematostella vectensis) and the blood fluke Schistosoma japonicum.[3][4][5][6][7][8] In some of these species the presence of miR-10 has been shown experimentally, in others the genes encoding miR-10 have been predicted computationally.

Genomic location

The mir-10 genes are found within the Hox gene clusters. In mammals there are four Hox gene clusters, these contain five genes encoding miRNAs (mir-10a, mir-10b, mir-196a-1, mir-196a-2 and mir-196b). The mir-10a gene is located upstream of Hoxb4 and the mir-10b gene is located upstream of Hoxd4.[9] Zebrafish have seven Hox gene clusters, genes encoding miR-10 (mir-10a, mir-10b-1, mir-10b-2 and mir-10c) are found in the Hox Ba, Bb, Ca and Da clusters. A fourth miR-10 gene (mir-10d) is found elsewhere in the genome, at a location homologous to the pufferfish HoxDd cluster.[10]

miR-10*

A miRNA can be derived from each arm of the pre-miRNA hairpin. The least common of these two miRNA products is denoted by the addition of * to the miRNA name.[11] Both miR-10 and miR-10* have been detected in Drosophila. There are many potential targets for miR-10* in Drosophila, including several Hox genes, indicating that miR-10* may also be functional.[12][13] In Drosophila most mature miR-10 sequences are produced from the 3' arm of the precursor while in the beetle Tribolium castaneum most production comes from the 5' arm.[14] These changes of arm preference during evolution are termed arm switching events, and they are relatively frequent during the evolution of microRNAs.[14][15]

Pattern of expression

In adult animals, expression of miR-10 is limited to specific organs. The highest levels of miR-10a and miR-10b have been found in the kidneys of mice. Lower levels of miR-10a are seen in small intestine, lung and spleen, and lower levels of miR-10b are seen in skeletal muscle. Expression of miR-10b has also been detected in the ovaries.[7][8][16] Adult zebrafish express miR-10a in heart, testis and ovary, and miR-10b in muscle and liver.[17]

In developing embryos, miR-10 is detected at specific stages. Zebrafish embryos show miR-10a expression from 48 to 120 hours post-fertilisation, and miR-10b expression from 12 to 120 hours post-fertilisation.[17]

In Drosophila expression of miR-10-3p is highest in 12- to 24-hour-old embryos and in 1st and 3rd instar larvae. Levels of miR-10-5p are highest in 12- to 24-hour-old embryos and much lower in larvae.[12]

In stage 5 Drosophila embryos (130–180 minutes post-fertilisation), miR-10 is distributed throughout 50-80% of the length of the egg. Later in development miRNA-10 becomes localised into bands, and levels decrease by stage 7 (195–200 minutes post-fertilisation). miR10 reappears by stage 11 (320–440 minutes post-fertilisation), where it is found in the ventral nerve cord, posterior midgut and hindgut. At stage 14 (620–680 hours post-fertilisation), miRNA-10 is localised to the posterior midgut and the anal pad.[18] In Drosophila larvae, miR-10-3p is found in the imaginal discs (groups of cells which are destined to become adult structures upon metamorphosis).[12] Expression of miR-10ba in mouse embryos shows a similar pattern to that of the Hoxb4 gene. Highest levels are found in the posterior trunk of the embryo, surrounding the hindlimb buds. Similarly, expression is restricted to the posterior trunk of chicken embryos.[6] In Zebrafish embryos expression of miR-10 is also restricted to the posterior trunk, later in development it is further restricted to the spinal cord.[17]

Targets of miR-10

A number of Hox genes have been shown to be regulated by miR-10. These genes encode transcription factors which are important in embryonic development. In zebrafish embryos, miR-10 binds to sites in the three prime untranslated region (3'UTR) of the HoxB1a and HoxB3a genes, which are important in anterior-posterior patterning during embryonic development. Binding of miR-10 leads to the repression of these genes. It also acts synergistically with HoxB4 to repress these genes. The mir-10 gene is located near to the HoxB1a and HoxB3a genes within the zebrafish genome, Hox-1 and Hox-3 paralogues located on different Hox clusters are not targets of miR-10.[19] Human HOXD10 gene has also been shown experimentally to be repressed by miR-10a and miR-10b.[9][20][21]

It has also been experimentally verified that miR-10a downregulates the human HOXA1 and HOXA3 genes.[21][22] Control of the Hox genes by miR-10 suggests that this microRNA may play an important role in development.[9]

In addition to the Hox genes, miR-10a represses the transcription factor USF2 and the Ran and Pbp1 genes.[23][24] The cell-surface proteoglycan Syndecan-1 is a target of miR-10b.[25]

miR-10a binds to the five prime untranslated region (5'UTR) of mRNAs encoding ribosomal proteins, and increases their translation. It binds immediately downstream of the 5' oligopyrimidine tract (5'TOP) motif, a region important in the regulation of ribosomal protein synthesis.[23]

Association with cancer

Recently there has been much interest in abnormal levels of expression of microRNAs in cancers. Upregulation of miR-10 has been found in a number of cancers. Increased levels of miR-10a have been found in glioblastoma, anaplastic astrocytomas, primary hepatocellular carcinomas and colon cancer. Increased levels of miR-10b have been found in glioblastoma, anaplastic astrocytomas, pancreatic cancer, and metastatic breast cancer.[9][20] Although high expression of miR-10b is found in metastatic breast cancers, it does not appear to be present at high levels in early breast cancers.[20][26] The expression of miR-10b is correlated with overall survival in 1262 breast cancer patients.[27]

Downregulation of miR-10a has been found in chronic myeloid leukemia. USF2, a target gene of miR-10a, has been found to be overexpressed in these leukemias.[24] Downregulation of miR-10a has also been found in acute myeloid leukemia, the most common acute leukemia affecting adults.[28] Conversely, miR-10a and miR-10b have found to be upregulated in acute myeloid leukemia with NPM1 mutations; these account for approximately a third of adult acute myeloid leukemia cases and contain mutations in the NPM1 gene which result in the relocation of NPM1 from the nucleus to the cytoplasm.[29] Upregulation of miR-10b has also been found in B-cell chronic lymphocytic leukemia, the most common type of leukemia.[30]

Genomic copy number abnormalities involving microRNA genes (both increases and decreases in copy number) have been found in cancers. A gain in copy number of the mir-10a gene has been found in melanoma and breast cancer.[31]

Upstream of the mir-10b gene is a promoter region containing a binding site for the Twist transcription factor (Twist). Binding of Twist to this promoter region induces miR-10b expression, leading to a reduced translation of the tumour suppressor HOXD10. This results in upregulation of RhoA/RhoC, Rho kinase activation and tumour cell invasion.[20][32]

See also

  • MicroRNA
  • Gene expression
  • Hox genes

References

1. ^{{cite journal |last1=Lee |first1=R. C. |last2=Ambros |first2=V |title=An Extensive Class of Small RNAs in Caenorhabditis elegans |journal=Science |volume=294 |issue=5543 |pages=862–4 |year=2001 |pmid=11679672 |doi=10.1126/science.1065329}}
2. ^{{cite journal |last1=Ambros |first1=Victor |title=MicroRNAsTiny Regulators with Great Potential |journal=Cell |volume=107 |issue=7 |pages=823–6 |year=2001 |pmid=11779458 |doi=10.1016/S0092-8674(01)00616-X}}
3. ^{{cite journal |last1=Li |first1=Sung-Chou |last2=Chan |first2=Wen-Ching |last3=Hu |first3=Ling-Yueh |last4=Lai |first4=Chun-Hung |last5=Hsu |first5=Chun-Nan |last6=Lin |first6=Wen-Chang |title=Identification of homologous microRNAs in 56 animal genomes |journal=Genomics |volume=96 |issue=1 |pages=1–9 |year=2010 |pmid=20347954 |doi=10.1016/j.ygeno.2010.03.009}}
4. ^{{cite journal |last1=Prochnik |first1=Simon E. |last2=Rokhsar |first2=Daniel S. |last3=Aboobaker |first3=A. Aziz |title=Evidence for a microRNA expansion in the bilaterian ancestor |journal=Development Genes and Evolution |volume=217 |issue=1 |pages=73–7 |year=2006 |pmid=17103184 |doi=10.1007/s00427-006-0116-1}}
5. ^{{cite journal |last1=Huang |first1=Jian |last2=Hao |first2=Pei |last3=Chen |first3=Hui |last4=Hu |first4=Wei |last5=Yan |first5=Qing |last6=Liu |first6=Feng |last7=Han |first7=Ze-Guang |last8=Diemert |first8=David Joseph |title=Genome-Wide Identification of Schistosoma japonicum MicroRNAs Using a Deep-Sequencing Approach |journal=PLoS ONE |volume=4 |issue=12 |pages=e8206 |year=2009 |pmid=19997615 |pmc=2785426 |doi=10.1371/journal.pone.0008206 |editor1-last=Diemert |editor1-first=David Joseph}}
6. ^1 {{cite journal |last1=Mansfield |first1=Jennifer H |last2=Harfe |first2=Brian D |last3=Nissen |first3=Robert |last4=Obenauer |first4=John |last5=Srineel |first5=Jalagani |last6=Chaudhuri |first6=Aadel |last7=Farzan-Kashani |first7=Raphael |last8=Zuker |first8=Michael |last9=Pasquinelli |first9=Amy E |title=MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression |journal=Nature Genetics |volume=36 |issue=10 |pages=1079–83 |year=2004 |pmid=15361871 |doi=10.1038/ng1421 |last10=Ruvkun |first10=Gary |last11=Sharp |first11=Phillip A |last12=Tabin |first12=Clifford J |last13=McManus |first13=Michael T}}
7. ^1 {{cite journal |last1=Teramura |first1=M |last2=Kobayashi |first2=S |last3=Hoshino |first3=S |last4=Oshimi |first4=K |last5=Mizoguchi |first5=H |title=Interleukin-11 enhances human megakaryocytopoiesis in vitro |journal=Blood |volume=79 |issue=2 |pages=327–31 |year=1992 |pmid=1370382}}
8. ^1 {{cite journal |last1=Beuvink |first1=I. |last2=Kolb |first2=F. A. |last3=Budach |first3=W. |last4=Garnier |first4=A. |last5=Lange |first5=J. |last6=Natt |first6=F. |last7=Dengler |first7=U. |last8=Hall |first8=J. |last9=Filipowicz |first9=W. |title=A novel microarray approach reveals new tissue-specific signatures of known and predicted mammalian microRNAs |journal=Nucleic Acids Research |volume=35 |issue=7 |pages=e52 |year=2007 |pmid=17355992 |pmc=1874652 |doi=10.1093/nar/gkl1118 |last10=Weiler |first10=J.}}
9. ^1 2 3 {{cite journal |last1=Lund |first1=A H |title=MiR-10 in development and cancer |journal=Cell Death and Differentiation |volume=17 |issue=2 |pages=209–14 |year=2009 |pmid=19461655 |doi=10.1038/cdd.2009.58}}
10. ^{{cite journal |last1=Woltering |first1=Joost M |last2=Durston |first2=Antony J |title=The zebrafish hoxDb cluster has been reduced to a single microRNA |journal=Nature Genetics |volume=38 |issue=6 |pages=601–2 |year=2006 |pmid=16736008 |doi=10.1038/ng0606-601}}
11. ^{{cite web |url=http://www.mirbase.org/help/nomenclature.shtml |title=miRBase |website= |accessdate=}}
12. ^1 2 {{cite journal |last1=Ruby |first1=J. G. |last2=Stark |first2=A. |last3=Johnston |first3=W. K. |last4=Kellis |first4=M. |last5=Bartel |first5=D. P. |last6=Lai |first6=E. C. |title=Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs |journal=Genome Research |volume=17 |issue=12 |pages=1850–64 |year=2007 |pmid=17989254 |pmc=2099593 |doi=10.1101/gr.6597907}}
13. ^{{cite journal |last1=Stark |first1=A. |last2=Kheradpour |first2=P. |last3=Parts |first3=L. |last4=Brennecke |first4=J. |last5=Hodges |first5=E. |last6=Hannon |first6=G. J. |last7=Kellis |first7=M. |title=Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes |journal=Genome Research |volume=17 |issue=12 |pages=1865–79 |year=2007 |pmid=17989255 |pmc=2099594 |doi=10.1101/gr.6593807}}
14. ^1 {{cite journal |last1=Griffiths-Jones |first1=S. |last2=Hui |first2=J. H. L. |last3=Marco |first3=A. |last4=Ronshaugen |first4=M. |title=MicroRNA evolution by arm switching |journal=EMBO Reports |volume=12 |issue=2 |pages=172–177 |year=2011 |pmid=21212805 |pmc=3049427 |doi=10.1038/embor.2010.191}}
15. ^{{cite journal |last1=Marco |first1=A. |last2=Hui |first2=J. H. L. |last3=Ronshaugen |first3=M. |last4=Griffiths-Jones |first4=S. |title=Functional shifts in insect microRNA evolution |journal=Genome Biology and Evolution |volume=2 |pages=686–696 |year=2010 |pmid=20817720 |pmc=2956262 |doi=10.1093/gbe/evq053}}
16. ^{{cite journal |last1=Landgraf |first1=Pablo |last2=Rusu |first2=Mirabela |last3=Sheridan |first3=Robert |last4=Sewer |first4=Alain |last5=Iovino |first5=Nicola |last6=Aravin |first6=Alexei |last7=Pfeffer |first7=SéBastien |last8=Rice |first8=Amanda |last9=Kamphorst |first9=Alice O. |title=A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing |journal=Cell |volume=129 |issue=7 |pages=1401–14 |year=2007 |pmid=17604727 |pmc=2681231 |doi=10.1016/j.cell.2007.04.040 |last10=Landthaler |first10=Markus |last11=Lin |first11=Carolina |last12=Socci |first12=Nicholas D. |last13=Hermida |first13=Leandro |last14=Fulci |first14=Valerio |last15=Chiaretti |first15=Sabina |last16=Foà |first16=Robin |last17=Schliwka |first17=Julia |last18=Fuchs |first18=Uta |last19=Novosel |first19=Astrid |last20=Müller |first20=Roman-Ulrich |last21=Schermer |first21=Bernhard |last22=Bissels |first22=Ute |last23=Inman |first23=Jason |last24=Phan |first24=Quang |last25=Chien |first25=Minchen |last26=Weir |first26=David B. |last27=Choksi |first27=Ruchi |last28=De Vita |first28=Gabriella |last29=Frezzetti |first29=Daniela |last30=Trompeter |first30=Hans-Ingo}}
17. ^1 2 {{Cite journal | last1 = Wienholds | first1 = E. | last2 = Kloosterman | first2 = W. P. | last3 = Miska | first3 = E. | last4 = Alvarez-Saavedra | first4 = E. | last5 = Berezikov | first5 = E. | last6 = De Bruijn | first6 = E. | last7 = Horvitz | first7 = H. R. | last8 = Kauppinen | first8 = S. | last9 = Plasterk | first9 = R. H. | title = MicroRNA Expression in Zebrafish Embryonic Development | doi = 10.1126/science.1114519 | journal = Science | volume = 309 | issue = 5732 | pages = 310–311 | year = 2005 | pmid = 15919954| pmc = }}
18. ^{{cite journal |last1=Aboobaker |first1=A. A. |last2=Tomancak |first2=P |last3=Patel |first3=N |last4=Rubin |first4=GM |last5=Lai |first5=EC |title=Drosophila microRNAs exhibit diverse spatial expression patterns during embryonic development |journal=Proceedings of the National Academy of Sciences |volume=102 |issue=50 |pages=18017–22 |year=2005 |pmid=16330759 |pmc=1306796 |doi=10.1073/pnas.0508823102}}
19. ^{{cite journal |last1=Woltering |first1=Joost M. |last2=Durston |first2=Antony J. |last3=Raible |first3=David |title=MiR-10 Represses HoxB1a and HoxB3a in Zebrafish |journal=PLoS ONE |volume=3 |issue=1 |pages=e1396 |year=2008 |pmid=18167555 |pmc=2148072 |doi=10.1371/journal.pone.0001396 |editor1-last=Raible |editor1-first=David}}
20. ^1 2 3 {{cite journal |last1= Ma |first1= Li |last2= Teruya-Feldstein |first2= Julie |last3= Weinberg |first3= Robert A. |title= Tumour invasion and metastasis initiated by microRNA-10b in breast cancer |journal= Nature |volume= 449 |issue= 7163 |pages= 682–8 |year= 2007 |pmid= 17898713 |doi=10.1038/nature06174}}
21. ^1 {{cite journal |last1=Han |first1=L |last2=Witmer |first2=PD |last3=Casey |first3=E |last4=Valle |first4=D |last5=Sukumar |first5=S |title=DNA methylation regulates MicroRNA expression |journal=Cancer Biology & Therapy |volume=6 |issue=8 |pages=1284–8 |year=2007 |pmid=17660710 |doi=10.4161/cbt.6.8.4486}}
22. ^{{cite journal |last1=Garzon |first1=R. |last2=Pichiorri |first2=F |last3=Palumbo |first3=T |last4=Iuliano |first4=R |last5=Cimmino |first5=A |last6=Aqeilan |first6=R |last7=Volinia |first7=S |last8=Bhatt |first8=D |last9=Alder |first9=H |title=MicroRNA fingerprints during human megakaryocytopoiesis |journal=Proceedings of the National Academy of Sciences |volume=103 |issue=13 |pages=5078–83 |year=2006 |pmid=16549775 |pmc=1458797 |doi=10.1073/pnas.0600587103 |last10=Marcucci |first10=G |last11=Calin |first11=GA |last12=Liu |first12=CG |last13=Bloomfield |first13=CD |last14=Andreeff |first14=M |last15=Croce |first15=CM}}
23. ^1 {{cite journal |last1=Ørom |first1=Ulf Andersson |last2=Nielsen |first2=Finn Cilius |last3=Lund |first3=Anders H. |title=MicroRNA-10a Binds the 5′UTR of Ribosomal Protein mRNAs and Enhances Their Translation |journal=Molecular Cell |volume=30 |issue=4 |pages=460–71 |year=2008 |pmid=18498749 |doi=10.1016/j.molcel.2008.05.001}}
24. ^1 {{cite journal |last1=Agirre |first1=X. |last2=Jiménez-Velasco |first2=A. |last3=San José-Enériz |first3=E. |last4=Garate |first4=L. |last5=Bandrés |first5=E. |last6=Cordeu |first6=L. |last7=Aparicio |first7=O. |last8=Saez |first8=B. |last9=Navarro |first9=G. |title=Down-Regulation of hsa-miR-10a in Chronic Myeloid Leukemia CD34+ Cells Increases USF2-Mediated Cell Growth |journal=Molecular Cancer Research |volume=6 |issue=12 |pages=1830–40 |year=2008 |pmid=19074828 |doi=10.1158/1541-7786.MCR-08-0167 |last10=Vilas-Zornoza |first10=A. |last11=Pérez-Roger |first11=I. |last12=García-Foncillas |first12=J. |last13=Torres |first13=A. |last14=Heiniger |first14=A. |last15=Calasanz |first15=M. J. |last16=Fortes |first16=P. |last17=Román-Gómez |first17=J. |last18=Prósper |first18=F.}}
25. ^{{cite journal|last=Schneider|first=C|author2=Kässens, N |author3=Greve, B |author4=Hassan, H |author5=Schüring, AN |author6=Starzinski-Powitz, A |author7=Kiesel, L |author8=Seidler, DG |author9= Götte, M |title=Targeting of syndecan-1 by micro-ribonucleic acid miR-10b modulates invasiveness of endometriotic cells via dysregulation of the proteolytic milieu and interleukin-6 secretion|journal=Fertility and Sterility|date=Nov 30, 2012|pmid=23206733|volume=99|issue=3|pages=871–881.e1|doi=10.1016/j.fertnstert.2012.10.051}}
26. ^{{cite journal |last1=Gee |first1=Harriet E. |last2=Camps |first2=Carme |last3=Buffa |first3=Francesca M. |last4=Colella |first4=Stefano |last5=Sheldon |first5=Helen |last6=Gleadle |first6=Jonathan M. |last7=Ragoussis |first7=Jiannis |last8=Harris |first8=Adrian L. |title=MicroRNA-10b and breast cancer metastasis |journal=Nature |volume=455 |issue=7216 |pages=E8–9; author reply E9 |year=2008 |pmid=18948893 |doi=10.1038/nature07362}}
27. ^{{Cite journal|last=Lánczky|first=András|last2=Nagy|first2=Ádám|last3=Bottai|first3=Giulia|last4=Munkácsy|first4=Gyöngyi|last5=Szabó|first5=András|last6=Santarpia|first6=Libero|last7=Győrffy|first7=Balázs|date=2016-12-01|title=miRpower: a web-tool to validate survival-associated miRNAs utilizing expression data from 2178 breast cancer patients|journal=Breast Cancer Research and Treatment|volume=160|issue=3|pages=439–446|doi=10.1007/s10549-016-4013-7|issn=1573-7217|pmid=27744485}}
28. ^{{cite journal |last1=Jongen-Lavrencic |first1=M. |last2=Sun |first2=S. M. |last3=Dijkstra |first3=M. K. |last4=Valk |first4=P. J. M. |last5=Löwenberg |first5=B. |title=MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia |journal=Blood |volume=111 |issue=10 |pages=5078–85 |year=2008 |pmid=18337557 |doi=10.1182/blood-2008-01-133355}}
29. ^{{cite journal |last1=Garzon |first1=R. |last2=Garofalo |first2=M. |last3=Martelli |first3=M. P. |last4=Briesewitz |first4=R. |last5=Wang |first5=L. |last6=Fernandez-Cymering |first6=C. |last7=Volinia |first7=S. |last8=Liu |first8=C.-G. |last9=Schnittger |first9=S. |title=Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin |journal=Proceedings of the National Academy of Sciences |volume=105 |issue=10 |pages=3945–50 |year=2008 |pmid=18308931 |pmc=2268779 |doi=10.1073/pnas.0800135105 |last10=Haferlach |first10=T. |last11=Liso |first11=A. |last12=Diverio |first12=D. |last13=Mancini |first13=M. |last14=Meloni |first14=G. |last15=Foa |first15=R. |last16=Martelli |first16=M. F. |last17=Mecucci |first17=C. |last18=Croce |first18=C. M. |last19=Falini |first19=B.}}
30. ^{{cite journal |last1=Calin |first1=G. A. |last2=Liu |first2=CG |last3=Sevignani |first3=C |last4=Ferracin |first4=M |last5=Felli |first5=N |last6=Dumitru |first6=CD |last7=Shimizu |first7=M |last8=Cimmino |first8=A |last9=Zupo |first9=S |title=MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias |journal=Proceedings of the National Academy of Sciences |volume=101 |issue=32 |pages=11755–60 |year=2004 |pmid=15284443 |pmc=511048 |doi=10.1073/pnas.0404432101 |last10=Dono |first10=M |last11=Dell'Aquila |first11=ML |last12=Alder |first12=H |last13=Rassenti |first13=L |last14=Kipps |first14=TJ |last15=Bullrich |first15=F |last16=Negrini |first16=M |last17=Croce |first17=CM}}
31. ^{{cite journal |last1=Zhang |first1=L. |last2=Huang |first2=J |last3=Yang |first3=N |last4=Greshock |first4=J |last5=Megraw |first5=MS |last6=Giannakakis |first6=A |last7=Liang |first7=S |last8=Naylor |first8=TL |last9=Barchetti |first9=A |title=microRNAs exhibit high frequency genomic alterations in human cancer |journal=Proceedings of the National Academy of Sciences |volume=103 |issue=24 |pages=9136–41 |year=2006 |pmid=16754881 |pmc=1474008 |doi=10.1073/pnas.0508889103 |last10=Ward |first10=MR |last11=Yao |first11=G |last12=Medina |first12=A |last13=o'Brien-Jenkins |first13=A |last14=Katsaros |first14=D |last15=Hatzigeorgiou |first15=A |last16=Gimotty |first16=PA |last17=Weber |first17=BL |last18=Coukos |first18=G}}
32. ^{{cite journal |last1=Bourguignon |first1=L. Y. W. |last2=Wong |first2=G. |last3=Earle |first3=C. |last4=Krueger |first4=K. |last5=Spevak |first5=C. C. |title=Hyaluronan-CD44 Interaction Promotes c-Src-mediated Twist Signaling, MicroRNA-10b Expression, and RhoA/RhoC Up-regulation, Leading to Rho-kinase-associated Cytoskeleton Activation and Breast Tumor Cell Invasion |journal=Journal of Biological Chemistry |year=2010 |pmid=20843787 |doi=10.1074/jbc.M110.162305 |volume=285 |issue=47 |pages=36721–35 |pmc=2978601}}

Further reading

  • {{cite journal |last1=Lagos-Quintana |first1=M. |last2=Rauhut |first2=R |last3=Lendeckel |first3=W |last4=Tuschl |first4=T |title=Identification of Novel Genes Coding for Small Expressed RNAs |journal=Science |volume=294 |issue=5543 |pages=853–8 |year=2001 |pmid=11679670 |doi=10.1126/science.1064921|hdl=11858/00-001M-0000-0012-F65F-2 }}
  • {{cite journal |last1=Izzotti |first1=A. |last2=Calin |first2=G. A. |last3=Arrigo |first3=P. |last4=Steele |first4=V. E. |last5=Croce |first5=C. M. |last6=De Flora |first6=S. |title=Downregulation of microRNA expression in the lungs of rats exposed to cigarette smoke |journal=The FASEB Journal |volume=23 |issue=3 |pages=806–12 |year=2009 |pmid=18952709 |pmc=2653990 |doi=10.1096/fj.08-121384}}
  • {{cite journal|last=Chen|first=Z|author2=Jin, Y |author3=Yu, D |author4=Wang, A |author5=Mahjabeen, I |author6=Wang, C |author7=Liu, X |author8= Zhou, X |title=Down-regulation of the microRNA-99 family members in head and neck squamous cell carcinoma|journal=Oral Oncology|date=August 2012|volume=48|issue=8|pages=686–91|pmid=22425712|doi=10.1016/j.oraloncology.2012.02.020|pmc=3380146}}

External links

{{div col|colwidth=30em}}
  • {{Rfam|id=RF00104|name=mir-10 microRNA precursor family}}
  • {{miRBase|id=MIPF0000033|name=mir-10}}
  • {{miRBase|id=MIPF0000025|name=mir-99}}
  • {{miRBase|id=MIPF0000268|name=mir-51}}
  • {{miRBase|id=MIPF0000271|name=mir-57}}
  • miRBase entry for human miR-10a
  • miRBase entry for human miR-10b
  • miRDB predicted targets for human miR-10a
  • miRDB predicted targets for human miR-10b
  • miRNAMap entry for human miR-10a
  • miRNAMap entry for human miR-10b
  • [https://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:31497 HNGC entry for miR-10a]
  • [https://www.genenames.org/data/hgnc_data.php?hgnc_id=HGNC:31498 HGNC entry for miR-10b]
{{div col end}}{{miRNA precursor families}}{{DEFAULTSORT:Mir-10 Microrna Precursor Family}}

2 : MicroRNA|MicroRNA precursor families
随便看

　

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。

　

Copyright © 2023 OENC.NET All Rights Reserved
京ICP备2021023879号 更新时间：2024/11/12 18:25:08