| 词条 | Mir-130 microRNA precursor family |
| 释义 |
| Name = mir-130 microRNA precursor family | image = RF00258.jpg | width = | caption = Predicted secondary structure and sequence conservation of mir-130 | Symbol = mir-130 | AltSymbols = | Rfam = RF00258 | miRBase = MI0000448 | miRBase_family = MIPF0000034 | RNA_type = Gene; miRNA | Tax_domain = Eukaryota | GO = {{GO|0035195}} {{GO|0035068}} | SO = {{SO|0001244}} | CAS_number = | EntrezGene = | HGNCid = | OMIM = | PDB = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }} In molecular biology, miR-130 microRNA precursor is a small non-coding RNA that regulates gene expression. This microRNA has been identified in mouse ([https://archive.is/20121223195009/http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000156 MI0000156], MI0000408{{dead link|date=February 2018 |bot=InternetArchiveBot |fix-attempted=yes }}),[1] and in human ([https://archive.is/20121223040017/http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000448 MI0000448], MI0000748{{dead link|date=February 2018 |bot=InternetArchiveBot |fix-attempted=yes }}).[2] miR-130 appears to be vertebrate-specific miRNA and has now been predicted or experimentally confirmed in a range of vertebrate species ([https://archive.is/20121223051101/http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000034 MIPF0000034]). Mature microRNAs are processed from the precursor stem-loop by the Dicer enzyme. In this case, the mature sequence is excised from the 3' arm of the hairpin. It has been found that miR-130 is upregulated in a type of cancer called hepatocellular carcinoma.[3] It has been shown that miR-130a is expressed in the hematopoietic stem/progenitor cell compartment but not in mature blood cells.[4] References1. ^{{cite journal | last = Lagos-Quintana | first = M |author2=Rauhut R |author3=Yalcin A |author4=Meyer J |author5=Lendeckel W |author6=Tuschl T | year = 2002 | title = Identification of tissue-specific microRNAs from mouse | journal = Curr Biol | volume = 12 | pages = 735–739 | pmid = 12007417 | doi = 10.1016/S0960-9822(02)00809-6 | issue = 9}} 2. ^{{cite journal | last = Houbaviy | first = HB |author2=Murray MF |author3=Sharp PA | year = 2003 | title = Embryonic stem cell-specific MicroRNAs | journal = Dev Cell | volume = 5 | pages = 351–358 | pmid = 12919684 | doi = 10.1016/S1534-5807(03)00227-2 | issue = 2}} 3. ^{{cite journal |vauthors=Kutay H, Bai S, Datta J, etal | title = Downregulation of miR-122 in the rodent and human hepatocellular carcinomas | journal = J. Cell. Biochem. | volume = 99 | issue = 3 | pages = 671–8 | year = 2006 | pmid = 16924677 | doi = 10.1002/jcb.20982 | pmc=3033198}} 4. ^{{cite journal |vauthors=Escobar G, Moi D, Ranghetti A, etal | title = Genetic engineering of hematopoiesis for targeted IFN-α delivery inhibits breast cancer progression. | journal = Sci. Transl. Med. | volume = 6 | issue = 217 |date=Jan 2014 | pmid = 24382895 | url = http://stm.sciencemag.org/content/6/217/217ra3.short | pages = 217 | doi=10.1126/scitranslmed.3006353}} External links
2 : MicroRNA|MicroRNA precursor families |
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