“Mitiglinide”的意思、由来-开放百科全书

词条

Mitiglinide

释义

Pharmacology
Dosage
References
External links

{{Drugbox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 462252797
| IUPAC_name = (−)-(2S,3a,7a-cis)-α-Benzylhexahydro-γ-oxo-2-isoindolinebutyric acid
| image = Mitiglinide.svg
| tradename = Glufast
| Drugs.com = {{drugs.com|international|mitiglinide}}
| routes_of_administration = By mouth (tablets)
| CAS_number_Ref = {{cascite|changed|??}}
| CAS_number = 145375-43-5
| ATC_prefix = A10
| ATC_suffix = BX08
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 471498
| PubChem = 121891
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB01252
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 108739
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = D86I0XLB13
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D01854
| C=19 | H=25 | N=1 | O=3
| molecular_weight = 315.41 g/mol
| smiles = O=C(O)[C@@H](Cc1ccccc1)CC(=O)N3C[C@H]2CCCC[C@H]2C3
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C19H25NO3/c21-18(20-12-15-8-4-5-9-16(15)13-20)11-17(19(22)23)10-14-6-2-1-3-7-14/h1-3,6-7,15-17H,4-5,8-13H2,(H,22,23)/t15-,16+,17-/m0/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = WPGGHFDDFPHPOB-BBWFWOEESA-N
}}Mitiglinide (INN,^[1] trade name Glufast) is a drug for the treatment of type 2 diabetes.^[2]

Mitiglinide belongs to the meglitinide (glinide) class of blood glucose-lowering drugs and is currently co-marketed in Japan by Kissei and Takeda. The North America rights to mitiglinide are held by Elixir Pharmaceuticals. Mitiglinide has not yet gained FDA approval.

Pharmacology

Mitiglinide is thought to stimulate insulin secretion by closing the ATP-sensitive potassium K_ATP channels in pancreatic β cells.

Dosage

Mitiglinide is delivered in tablet form.

References

1. ^{{cite web|title=International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary names (Rec. INN): List 40|url=http://www.who.int/medicines/publications/druginformation/innlists/PL78.pdf|publisher=World Health Organization|accessdate=10 November 2016|page=187}}
2. ^{{cite journal |author=Malaisse WJ |title=Mitiglinide: a rapid- and short-acting non-sulfonylurea insulinotropic agent for the treatment of type 2 diabetic patients |journal=Expert Opin Pharmacother |volume=9 |issue=15 |pages=2691–8 |date=October 2008 |pmid=18803455 |doi=10.1517/14656566.9.15.2691 |url=http://www.informapharmascience.com/doi/abs/10.1517/14656566.9.15.2691 |deadurl=yes |archiveurl=https://web.archive.org/web/20150924034828/http://www.informapharmascience.com/doi/abs/10.1517/14656566.9.15.2691 |archivedate=2015-09-24 |df= }}

External links

Elixir Pharmaceuticals — website of the U.S. rights holder for mitiglinide.

4 : Carboxamides|Isoindoles|Meglitinides|Potassium channel blockers

随便看

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。